Fixing the methylation cycle

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    Fixing the methylation cycle


    I found this chart interesting:



    Question: if you have a high level of B12 in serum, doesn't it mean that it is not used properly?

    Then starting supplementing with active forms of folate, 5 formyl THF (folinic acid) and 5-methyl THF, would help to B12 getting used?

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    Before you do any supplementing you would need to do a urine organic acids and metabolic analysis. From this you could then know where your issues lie and hence what supplements you require.

    From those tests Elevated Sarcosine would indicate a folic acid deficiency due to not enough being supplied in the diet or a MTHFR mutation in which case you would need Folinic Acid - methylated form.

    High B12 can be from too much protein foods and foods containing B12, again you would need to do the tests to get a definitive answer. On the other hand low "normal" B12 with elevated folic acid would indicate the folate is building up in the body and becoming useless. Methylfolate trap.
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    Quote Originally Posted by MetalMX View Post
    Before you do any supplementing you would need to do a urine organic acids and metabolic analysis. From this you could then know where your issues lie and hence what supplements you require.

    From those tests Elevated Sarcosine would indicate a folic acid deficiency due to not enough being supplied in the diet or a MTHFR mutation in which case you would need Folinic Acid - methylated form.

    High B12 can be from too much protein foods and foods containing B12, again you would need to do the tests to get a definitive answer. On the other hand low "normal" B12 with elevated folic acid would indicate the folate is building up in the body and becoming useless. Methylfolate trap.
    I do agree but I don't know if such analysis is available in France.
    You should know that France has 10 years if not more of delay. For instance when I asked to get a test for estradiol or SGHB, they look at me like I was an alien. I ask for zinc and copper to my doctor and she told me that we don't do that.
    So even basic tests are not regular in France.

    I don't have the chance like you to live in US.
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    By the way im in Australia

    Testing is pretty good here just like the U.S.

    Sorry to hear that i didn't know it was like that in France. But The Genova ONE test can be ordered in a lot of countries as they have locations all over the world. Check their website.
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    Quote Originally Posted by MetalMX View Post
    By the way im in Australia

    Testing is pretty good here just like the U.S.

    Sorry to hear that i didn't know it was like that in France. But The Genova ONE test can be ordered in a lot of countries as they have locations all over the world. Check their website.
    Yes I have found one in UK but this is too expensive for me at the moment. I would have to convince my wife to have the test as gift of my birthday :-)
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