Undermethylation and OverMethylation?

Page 2 of 6 First 1234 ... Last

  1. Quote Originally Posted by MetalMX View Post
    So what dosage of SAMe per day should be used to improve undermethylation?... ive just picked up some
    start 200 mgs for 3 days then up it after that ..
    I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.


  2. Quote Originally Posted by MetalMX View Post
    So what dosage of SAMe per day should be used to improve undermethylation?... ive just picked up some
    Since I knew my histamines were sky-high I started w/ 200mg twice a day and after 2 weeks ramped up to 400mg twice a day. Some people get insomnia and anxiety... for me it relieved these symptoms. I suspect people with a bad reaction to sam-e aren't undermethylated after all. Oh, you need a good quality brand... it should be in blister packs... I use Jarrow. I also take some TMG and 5-MTHF (activated folic acid) to prevent homocysteine build-up and continue the sam cycle.
    •   
       


  3. when you say 200mg a day, do you mean 200mg tablets, or the 400mg tablets that yeild 200mg of actual SAMe. That pissed me off when I first realized it, i was like "wtf, i paid for 400mg tabs"

  4. Quote Originally Posted by EasyEJL View Post
    when you say 200mg a day, do you mean 200mg tablets, or the 400mg tablets that yeild 200mg of actual SAMe. That pissed me off when I first realized it, i was like "wtf, i paid for 400mg tabs"
    400 mgs can nto be broken due to enteric coating.
    I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.

  5. Quote Originally Posted by LeanGuy View Post
    Since I knew my histamines were sky-high I started w/ 200mg twice a day and after 2 weeks ramped up to 400mg twice a day. Some people get insomnia and anxiety... for me it relieved these symptoms. I suspect people with a bad reaction to sam-e aren't undermethylated after all. Oh, you need a good quality brand... it should be in blister packs... I use Jarrow. I also take some TMG and 5-MTHF (activated folic acid) to prevent homocysteine build-up and continue the sam cycle.

    So Leanguy what noticable differences have you noticed in terms of feeling better?

    I dont even have to test my histamine and i know im undermethylated last time i checked my dopamine, noradrenaline and adrenaline all we're depleted. I even had low cholesterol.
    •   
       


  6. Undermethylation and zinc depletion.

    This is something i recieved from a doctor i saw before. He diagnosed undermethylation in my sister when she saw him.
    Attached Images Attached Images

  7. Well i had a adverse reaction to SAMe on the second day i also took 200mg but in the evening i started feeling very mentally unwell. I don't know what happened but i totally felt spaced out and its extremely hard to explain, felt i was losing my breath too.

    Ill stop the SAMe and first check my urine amino acid levels and blood histamine so i know 100% if im over or undermethylated.

  8. Quote Originally Posted by MetalMX View Post
    Undermethylation and zinc depletion.

    This is something i recieved from a doctor i saw before. He diagnosed undermethylation in my sister when she saw him.
    it did not take a rocket scientist to known you where undermethylated..
    It is also a genetic issue as well stemming from mutatation in the genes that I have already mentioned. Sam-e is a direct route..folonic acid, methyl b-12, are the indirect route
    I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.

  9. Quote Originally Posted by The Matrix View Post
    400 mgs can nto be broken due to enteric coating.
    I wasn't talking about breaking them. on 400mg tabs it reads

    S-Adenosyl-Methionine tosylate disulfate - 400mg
    (yielding 200mg S-Adenosyl-Methionine)

    so I was wondering whether he was talking about 400mg tabs, or 400mg active

  10. Quote Originally Posted by EasyEJL View Post
    I wasn't talking about breaking them. on 400mg tabs it reads

    S-Adenosyl-Methionine tosylate disulfate - 400mg
    (yielding 200mg S-Adenosyl-Methionine)

    so I was wondering whether he was talking about 400mg tabs, or 400mg active
    200 mgs active
    I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.

  11. Quote Originally Posted by MetalMX View Post
    Well i had a adverse reaction to SAMe on the second day i also took 200mg but in the evening i started feeling very mentally unwell. I don't know what happened but i totally felt spaced out and its extremely hard to explain, felt i was losing my breath too.

    Ill stop the SAMe and first check my urine amino acid levels and blood histamine so i know 100% if im over or undermethylated.
    I had the same side effects on Sam-e. Got fine after one day.

  12. Quote Originally Posted by aisstea View Post
    I had the same side effects on Sam-e. Got fine after one day.
    This is weird, my wife had the same problem with sam-e, and her histamines are mildly elevated. She's doing fine with methionine + tmg

  13. This is the place im going to for the DNA testing.

    Have a look it has some good diagrams and talking about hypomethylation. They also provide you with appropriate nutrition and supplement therapy once you know where your genetic mutations are.
    Attached Images Attached Images

  14. Quote Originally Posted by LeanGuy View Post
    This is weird, my wife had the same problem with sam-e, and her histamines are mildly elevated. She's doing fine with methionine + tmg
    Look up at my other reply
    People may do better on TMG, folonic acid, methyl b-12 and not sam-e

    She might do good on glutathione patches too
    I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.

  15. Quote Originally Posted by MetalMX View Post
    This is the place im going to for the DNA testing.

    Have a look it has some good diagrams and talking about hypomethylation. They also provide you with appropriate nutrition and supplement therapy once you know where your genetic mutations are.
    I am glad that you are getting down to hopefully the root of the problem..now knowing that it may be a genetic link which no medicine can help cure. Also undermethylation can lead in to adrenal fatigue because it can deplete serotonin which starts the cascade of events of high glutamate, high cortisol, high rt3, low dhea, mineral imbalnace..Gear may have been straw that broke the camels back which may have triggered it. I am glad you are with good dr's.. i have an idea you will have an underactive MS over active CBS, under active 5 mthfrr..Depending on where you got the gear it may have been contaminated with some kind of viral infection, especially if you were using tren...That stuff is made in back yard labs..So I hope that you learned a lesson. What caused all this mess would be a tainted or contaminated batch of steroids, over traning, undereating, that stressed your system over taxing your detoxifcation system triggering a genetic mutation.

    PS I will just added to your bill HAHAHA
    I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.

  16. I'm going to give SAMe another try.

    Starting with 200mg of S-Adenosyl Methionine (from 400mg of SAMe tosylate dusulfate) and then ramping up to 400mg of S-Adenosyl Methionine (from 800mg of SAMe tosylate dusulfate).

    Trying this stuff here: https://www.prohealth.com/shop/produ...ab/Label#title

    It's in the blister packs. Supposed to be high quality. Also going to take NAC + extra Vitamin C with this along with some of their B-12 Extreme sublinguals (full spectrum b-12, including methylcobalamin) and 10mg of NADH as well. Should be a nice new protocol in addition to what I am already taking. NADH sounds promising. ALCAR and NA-RALA is also going to be part of this, and a small amount of l-histadine which I've got in bulk.

  17. nice price there too

  18. Yeah definitely.

    I didn't realize that NAC can cause zinc deficiency though, I've ordered 2 bottles each of MST's ZMK + MVP, so my minerals should be more than covered. I still can't stress enough how great MST's ZMK is. Best mineral product I've seen ever. Full spectrum krebs chelated mineral matrix, best I've seen for athletes. Goes far above and beyond simple ZMA. I seriously don't know what I would do without my MVP/ZMK..nothing comes close to it for me where it comes to supplementation.

  19. Btw, does anyone know if it's an issue taking so many acetylated products?

    I once read a concern about it before but can't remember the source.

  20. Quote Originally Posted by The Matrix View Post
    I am glad that you are getting down to hopefully the root of the problem..now knowing that it may be a genetic link which no medicine can help cure. Also undermethylation can lead in to adrenal fatigue because it can deplete serotonin which starts the cascade of events of high glutamate, high cortisol, high rt3, low dhea, mineral imbalnace..Gear may have been straw that broke the camels back which may have triggered it. I am glad you are with good dr's.. i have an idea you will have an underactive MS over active CBS, under active 5 mthfrr..Depending on where you got the gear it may have been contaminated with some kind of viral infection, especially if you were using tren...That stuff is made in back yard labs..So I hope that you learned a lesson. What caused all this mess would be a tainted or contaminated batch of steroids, over traning, undereating, that stressed your system over taxing your detoxifcation system triggering a genetic mutation.

    PS I will just added to your bill HAHAHA

    Yeah i used tren as well as test... i hope to god things will improve for me. Im not messing with gear ever again thats for sure. Coupled with arimidex use which further suppressed my immune system while on possibly contaminated roids ugh! bad decisions...

    lol added to my bill the testing is already going to cost me a fortune.

  21. subbed so i can get an email saying im subscribed so i can come back to this at a later date and soak up information and learn as much as i can...

  22. Quote Originally Posted by MetalMX View Post
    Yeah i used tren as well as test... i hope to god things will improve for me. Im not messing with gear ever again thats for sure. Coupled with arimidex use which further suppressed my immune system while on possibly contaminated roids ugh! bad decisions...

    lol added to my bill the testing is already going to cost me a fortune.
    I think the problem lies in contamination of TREN would be the lost logical explaination for everything. I have ran across this with alot of my clients who where body builders and experiencing un explained fatigue and chronic fatigue symptoms which dr's had no clue where they came from. Infections also can alter the methylation cycle which could explain alot of your other symptoms as well. Mercury and infections go hand and hand.
    I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.

  23. Found something interesting + related today:

    The ketogenic diet increases mitochondrial glutathione levels
    The ketogenic diet (KD) is a high-fat, low carbohydrate diet...We sought to determine whether the KD improves mitochondrial redox status....GSH (glutathione) is a major mitochondrial antioxidant that protects mitochondrial DNA (mtDNA) against oxidative damage...the results demonstrate that the KD up-regulates GSH biosynthesis, enhances mitochondrial antioxidant status, and protects mtDNA from oxidant-induced damage.
    http://www.ncbi.nlm.nih.gov/sites/entrez/18466343

  24. Hmm well damn. thats interesting

  25. Quote Originally Posted by Gutterpump View Post
    Found something interesting + related today:
    Provided the proper substrates are there which need to be taken in a higher dosage other wise you could end up with fatty liver and diabetes on these types of diet. Ketodiets are for diabetes or seizures patients.
    I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.
  •   

      
     

Similar Forum Threads

  1. will be posting before and after pics soon
    By hamper19 in forum Anabolics
    Replies: 15
    Last Post: 09-20-2015, 08:24 AM
  2. Undermethylation and Autoimmune issues
    By Duhhbeach in forum Male Anti-Aging Medicine
    Replies: 7
    Last Post: 11-19-2013, 04:13 PM
  3. adrenal fatigue and undermethylation
    By hardasnails1973 in forum Male Anti-Aging Medicine
    Replies: 8
    Last Post: 09-25-2007, 02:13 AM
  4. Your Thoughts And Opinions on Keto Dieting??
    By YellowJacket in forum Weight Loss
    Replies: 28
    Last Post: 12-02-2002, 01:12 AM
  5. Fina and 1-test
    By BrKonman in forum Anabolics
    Replies: 37
    Last Post: 10-26-2002, 01:54 PM
Log in
Log in