HCG Monotherapy: Pregnenolone necessary?

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    HCG Monotherapy: Pregnenolone necessary?


    To all those on HCG Monotherapy, is it necessary to supplement with Pregnenolone, as it is standard procedure on most TRT and TRT+HCG protocols. I take anywhere from 250-500IU ED. I never exceed 3500IU/week, and never go below 2000IU/wk. I take .15mg Arimidex ED. I know Dr. John Crisler often gives his patients Preg cream for those on his TRT + 500IU/wk patients, as a safeguard against low PREG, but I am on HCG Monotherapy, and thus am enducing far more 450cc enzyme pathway stimulation CHOL->PREG, and feel that it is overkill, and will likely overstimulate the 450cc pathway.

    Rucksicht

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    Quote Originally Posted by living2die View Post
    To all those on HCG Monotherapy, is it necessary to supplement with Pregnenolone, as it is standard procedure on most TRT and TRT+HCG protocols. I take anywhere from 250-500IU ED. I never exceed 3500IU/week, and never go below 2000IU/wk. I take .15mg Arimidex ED. I know Dr. John Crisler often gives his patients Preg cream for those on his TRT + 500IU/wk patients, as a safeguard against low PREG, but I am on HCG Monotherapy, and thus am enducing far more 450cc enzyme pathway stimulation CHOL->PREG, and feel that it is overkill, and will likely overstimulate the 450cc pathway.

    Rucksicht
    It is good idea to do blood tests to prevent guessing:

    DHEA sulfate
    Progesterone, LC/MS/MS
    Pregnenolone
    Estradiol, Ultrasensitive, LC/MS/MS (30289X)
    Estrone, LC/MS/MS (23244X)
    Testosterone, Free, Bio/Total (LC/MS/MS)
    Dihydrotestosterone (204X)
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    Jansz,
    Your hormone testing is more extensive than the anti-doping tests they performed on Usain Bolt at the Beijing Olympics.

    Did you ever get a hormone panel done prior towards your supplementation with PREGnenolone? Did you get your hormone panel checked when you were on TRT + HCG alone?


    Quote Originally Posted by JanSz View Post
    It is good idea to do blood tests to prevent guessing:

    DHEA sulfate
    Progesterone, LC/MS/MS
    Pregnenolone
    Estradiol, Ultrasensitive, LC/MS/MS (30289X)
    Estrone, LC/MS/MS (23244X)
    Testosterone, Free, Bio/Total (LC/MS/MS)
    Dihydrotestosterone (204X)
    •   
       

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    Quote Originally Posted by living2die View Post
    Jansz,
    Your hormone testing is more extensive than the anti-doping tests they performed on Usain Bolt at the Beijing Olympics.

    Did you ever get a hormone panel done prior towards your supplementation with PREGnenolone? Did you get your hormone panel checked when you were on TRT + HCG alone?
    I do not have blood reports that you are interested in.

    I do my testing as I learn about them.
    Lucky I can find a doc who obliges with testing and have insurance that pays for most of it, otherwise $$ would be a problem, I am retired.
    My state of low testosterone exists most likely at least 10 years, most likely much longer.
    About 6 yers ago it started affecting my sex life.
    4 yers ago I started T supplentation.

    I want to talk now about this three:
    DHEA sulfate
    Progesterone, LC/MS/MS
    Pregnenolone

    Originally my DHEA was low, so I started supplementing, with a goal as per LEF, (DHEA 500-640 g/dL)
    At one point I had DHEAs=369 but to get there I used 350mg/day.
    I also had progesterone=1.4 (very good)

    Reading the boards I see people doing max about 50mg
    So I got scared and reduced to 50mg/day DHEA.

    That resulted in minimal values for all three
    DHEA, progesterone, Pregnenolone, all below low limits.

    I am back to 400mg/day DHEA, and keep using the 200mg preg that I always use.

    Will see my levels on the next test.
    .
    .

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