A number of hormones being off can cause depression. I suffered from depression and suffered through the shuffle of meds that did nothing for me. My Dr put me on Androgel and my depression cleared in three days!!!!!! I was like being reborn. I had low free T and my TT then was 379. A year later I've tried every type of T therapy, hoping injections would work just because they're the most convenient, but all that seems to work for me is Androgel and HCG. My Dr is against HCG mono therapy so this month I'm going to combine HCG and Androgel and go from there. A lot of people always forget one hormone and that's DHT which happens to be the reason I don't do well on injections even up to 200mg a week. DHT is a strong antidepressant and drives libido. It's role in the central nervous system is huge. Also if you try TRT don't stop if one therapy doesn't do it for you. I've been on compounded cream, compounded gel, Androgel, HCG, Adex alone, and shots. They all have a different result and feel.