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Steroid 5α-reductases and 3α-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism . Best Practice & Research Clinical Endocrinology & Metabolism , Volume 15 , Issue 1 , Pages 79 - 94 Y . Jin
5α-DHT is formed from circulating testosterone by the action of the type 2 steroid 5α-reductase (5α-R) and its action is terminated by the action of a reductive 3α-hydroxysteroid dehydrogenase (3α-HSD) which forms the weak androgen 3α-androstanediol. Oxidative 3α-HSD isoforms, however, can provide an alternative source of potent androgens by converting 3α-androstanediol to 5α-DHT.
Over at bb.com they will tell you that 3aHSD is selective, and that may be somewhat true for ONE isoform, but never is the situation cut and dry that way.
5α-DHT is formed from circulating testosterone by the action of the type 2 steroid 5α-reductase (5α-R) and its action is terminated by the action of a reductive 3α-hydroxysteroid dehydrogenase (3α-HSD) which forms the weak androgen 3α-androstanediol. Oxidative 3α-HSD isoforms, however, can provide an alternative source of potent androgens by converting 3α-androstanediol to 5α-DHT.
Over at bb.com they will tell you that 3aHSD is selective, and that may be somewhat true for ONE isoform, but never is the situation cut and dry that way.
