generate and benzos...
- 06-09-2011, 11:14 PM
- 06-10-2011, 06:19 PM
- 06-11-2011, 03:10 PM
06-11-2011, 03:32 PM
06-11-2011, 03:35 PM
give it time my friend!, fridays through the weekend are slow around here.. due to family lives and such, and doing the honey do lists! hahaha
06-11-2011, 06:52 PM
LG Sciences Board Rep
These statements have not been evaluated by the FDA, do not constitute medical advice, and are not official or authorized comments by LG Sciences, LLC.
06-11-2011, 06:53 PM
06-11-2011, 08:17 PM
Because extracts of kudzu have been used as a hangover remedy in China for many centuries, we tested the ability of NPI-031G (puerarin), an isoflavone isolated from kudzu, to counteract anxiogenic effects associated with withdrawal from chronic alcohol exposure. NPI-O31G (50 and 150 mg/kg ip) significantly increased the social interaction and locomotor activity reduced by withdrawal from 17 days of alcohol (7%) diet. The effects of NPI-031G resembled those of the benzodiazepine antagonist, flumazenil (5 mg/kg), and the 5-HT2C antagonist, SB 242084 (1 mg/kg). In a separate study, control rats were pretreated with NPI-031G (30 min) and then given the anxiogenic compounds DMCM, a benzodiazepine inverse agonist, or Ro 60 0175, a 5-HT2C agonist. NPI-031G significantly counteracted the reduction in social interaction induced by either compound. To identify a potential mechanism of action of NPI-031G, synaptoneurosomes were isolated from the cerebral cortex of untreated rats and chloride uptake assays were carried out. NPI-031G did not have any effect on the stimulation of chloride uptake by muscimol, a GABA(A) agonist. However, it reduced the potentiation of muscimol-stimulated chloride uptake by flunitrazepam, a benzodiazepine agonist, at a concentration of 100 μM. A reduction in [3H]flunitrazepam binding was also seen at this concentration. These findings are consistent with NPI-031G being a weak benzodiazepine site antagonist.
Author Keywords: NPI-031G; Alcohol withdrawal; Benzodiazepine; GABA(A) and 5-HT2C receptors; Social interaction test; Anxiety-like behavior; Chloride uptake
Tap, snap, or nap.
06-11-2011, 08:21 PM
Basically everything I have read about puerarin seems to imply that it is contraindicated for those with panic disorder or general anxiety disorder, treated with benzodiazepines.
Tap, snap, or nap.
06-11-2011, 08:23 PM
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