To quote from the guide apparently few read:
Originally Posted by ozarkaBRAND
"Unlike GHRH, GHSs are resistant to well-known inhibitors of GH secretion. Studies demonstrate that hexarelin-mediated GH secretion is reduced but not blocked by a rise in circulating free fatty acids or by a glucose load..." - Growth Hormone Secretagogues, DatBtrue
From the studies you will find that fatty acids inhibit GH release even more than carbs. The studies show that maximal GH release occurs 30 minutes after GHRP-6 or GHRH+GHRP-6 is administered so ideally the GHRP-6 should be dosed on an empty stomach 30 minutes before a meal.
There is no need or benefit to go to extremes.