Hemogex...the real thing?

dieselken77 · 07-16-2008, 03:07 PM

Been taking Hemogex for about a week now, and I've already noticed better sleep, increased energy at work (I am at a desk all day and usually dying by early afternoon), a perpetual pump and an odd type of strength increase in the gym...not lifting so much more in terms of lbs (weight is up slightly though) but everything just feels solid. It's like my joints feel better. I have been having some slight tendonitis in my right wrist and bicep, and since taking the hemo it's gotten less and less to where I don't feel it anymore at all....can this stuff be the real deal?? Can anyone post similar experiences with Hemogex?????

Cal · 07-18-2008, 03:56 AM

Is this a joke?

dieselken77 · 07-18-2008, 07:00 AM

why would I waste my time posting if this was a joke? I've had decent success with VPX products in the past (i.e. M1T - BUT ANY M1T in the day was prob all the same). But Im no die hard VPX fan by any means...just stating that this product seems to have some effect and was wondering if anyone has had similar benefits. I also noticed very quick finger nail and facial hair growth (just noting that because I've seen others mention it. I've tried alot of supps in my day, so I can tell when I'm getting effects from a supplement.

Cal · 07-18-2008, 04:24 PM

The reason I ask is that even real GH doesn't show effects that quickly, so you are definitely, 100% for sure experiencing placebo effect.

dieselken77 · 07-18-2008, 08:52 PM

have you run gh cycles before? If so, what length,doseage etc. until you saw effects?

datBtrue · 07-18-2008, 09:39 PM

Quote:

Originally Posted by dieselken77

have you run gh cycles before? If so, what length,doseage etc. until you saw effects?

What he's trying to tell you is that whatever "effect" you are experiencing...whatever "feel good" you got going from this product is not attributable to the "Growth Hormone Releasing Peptide - 2" (GHRP-2) that they claim is in the product.

GHRP-2 has very low oral bioavailability...perhaps 1%. I doubt that they would put 10mgs of GHRP-2 into each drink as this would cost them (even wholesale) more than $10 per drink.

Plus their claim of modifying the terminal to a simple akyl to increase oral bioavailability is doubtfully very effective. There is nothing in the research that indicates that this modification will provide the benefit they claim.

All of this aside ...even IF you got an increase spike of GH release from a drink you won't feel it. GH doesn't work that way.

Enjoy your drink.

But if you want to get GH levels up you need to either inject GH or a growth hormone releasing hormone analog (like CJC-1295) and/or a growth hormone releasing peptide (like GHRP-6).

dieselken77 · 07-18-2008, 10:51 PM

I've read it actually is quite orally bioavailable.

datBtrue · 07-18-2008, 11:51 PM

Quote:

Originally Posted by dieselken77

I've read it actually is quite orally bioavailable.

From where? Post your science.

Here's the very tip of my science:

Dat's - CJC-1295 & GHRP-6 (Basic Guides)

If after reading my thread you need me to post a study or two or three... to clarify something for a curious mind I don't mind doing that.

I haven't even mentioned the desensitization that rapidly occurs from oral ingestion of GHRPs...

dieselken77 · 07-19-2008, 12:22 AM

Here is a quick excerpt from one of a few research studies I've read. I can't really validate the sources of any of this info however....

The reason GHRP-2 is best for a science-based formula is because the GH-releasing activity of GHRP-2 is effective even with oral administration. Studies show that the GH releasing effect of GHRP-2 will undergo partial desensitization during continuous infusion, but much less during intermittent oral administration, which is one reason that a science-based formula would be most effective when given in on and off cycles.[/i][/i][/i][/i][/i][/i]

http://sacota.com/en/research/page8.html

dieselken77 · 07-19-2008, 12:25 AM

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datBtrue · 07-19-2008, 01:49 AM

Quote:

Originally Posted by dieselken77

Here is a quick excerpt from one of a few research studies I've read. I can't really validate the sources of any of this info however....

The reason GHRP-2 is best for a science-based formula is because the GH-releasing activity of GHRP-2 is effective even with oral administration. Studies show that the GH releasing effect of GHRP-2 will undergo partial desensitization during continuous infusion, but much less during intermittent oral administration, which is one reason that a science-based formula would be most effective when given in on and off cycles.[/i][/i][/i][/i][/i][/i]

http://sacota.com/en/research/page8.html

That's not science. GHRP-2 like all the GHRPS are minimally orally bioavailable. But the percentage is so low that Merck spent a lot of time develpoing MK-0677 a non-peptide GHS-mimetic that IS highly bioavailable.

Yes as I noted in my article desensitaztion does occur via constant infusion. Do you know what constant infusion is bro?

It is where an IV is hooked up and a drug/peptide is continually administered. That has nothing to do with a subcutaneous injection....which if given at intervals is intermittent.

In addition GHRPs by the oral administration route exhibit a delay in exciting the hypothalamic neurons probably because they do not cross the blood brain barrier as rapidly. This means that they wouldn't act as quickly as adminstration by subcutaneous injection.

Are you familiar with the term tachyphylaxia? That is what occurs when GHRP-2 and other GHS are administered orally. They loose effectiveness even when dosed intermittently. This is an effect that is common to a lot of oral medications. By-the-way it basically means "a decreased response to a medicine given over a period of time so that larger doses are required to produce the same response."

By the way that site that is serving as your scientific source...the one that use the term "science-based formula"...it is NOT a scientific journal or medical journal. They sell you products based on this "science-based formula" language.

datBtrue · 07-19-2008, 02:06 AM

Quote:

Originally Posted by dieselken77

References
...

You do realize that I have actually read the full study for almost half of those citations. I wouldn't wish that kind of boredom on my worst enemy...and yet you chose to post a list of references NONE of which support your point.

You may wish to read Roy G. Smith's account of his research at Merck in discovering MK-0677 a highly orally bioavailable GHS. It can be found in the following citation:

Peptidomimetic Regulation of Growth Hormone Secretion
Endocr. Rev., Roy G. Smith..., Oct 1997; 18: 621 - 645.

Why would Merck go to all this trouble if GHRP-2 was so highly orally bioavailable....hmmmm....here is a sentence or two from that article...

The peptide GHRP-6 was of ideal size, but because its receptor had not been identified, and cell lines responsive to GHRP-6 were unknown, high volume screening for a peptidomimetic was impractical. Based on these considerations, investigators modified the structure of GHRP-6 and identified more potent peptides (4, 5, 6, 18). For example, activity was enhanced by replacing D-Trp2 by D-2-(2-napthyl)alanine and His by D-alanine to furnish GHRP-2 (D-Ala-D-2 Nal-Ala-Trp-D-Phe-Lys-NH2) (5). However, the peptides still had low oral bioavailability....

I added the bold of course.

dieselken77 · 07-19-2008, 05:54 PM

ow you got alot of time on your hands bro! thx for the info though......you studying your phd or what?