GDF-8 shRNA

Page 3 of 5 First 12345 Last

  1. Maybe Mr. Black can tell us how much his research subject used so we can have an idea.:



    Quote Originally Posted by EasyEJL View Post
    yeah, thats what I thought I saw. i was just wondering what amount of mass that dosage was meant for.


  2. Well, i posted something about this on another site i visit alot and has many reputable people, especially in the AAS/Peptide catergory and got this feedabck...
    If he injected himself with a viral vector to silence myostatin, he is a complete idiot. There is so many problems with this, i don't even want to get into it.

    Gene therapy has been almost universally unsuccessful, requires repeated dosing and continued modification of one's genomic DNA, and has resulted in many deaths. For instance, from the induction of cancer.

    I am amazed he got ahold of this. Basically, this is really only available for use in laboratory animals.


    EVERYONE: DO NOT DO THIS. ITS THE MOST STUPID IDEA IMAGINABLE AT THIS POINT.
    If this guy really is doing this, you need to tell hiim that it is very dangerous and it's not permanent, as he believes from the thread. Basically the vector will integrate and express for a few months and then get ****ed up by methylation and DNA excision/repair mechanisms.

    It is very unfortunate if he is actually doing this. Again, this is the kind of thing that's only available for administering to laboratory animals for scientific experiment.
    •   
       


  3. hmm well they are wrong in one aspect, it is available for human use, however its meant for in-vitro use. places I found allowed you to specify rat or human shRNA for a variety of things.

  4. Quote Originally Posted by EasyEJL View Post
    hmm well they are wrong in one aspect, it is available for human use, however its meant for in-vitro use. places I found allowed you to specify rat or human shRNA for a variety of things.
    yes, i did mention that. Im waiting for a response and i did ask him if he'd be willing to sign up here and talk about anything. He is very reputable and experienced and i think he'd be a great addition over here.

  5. You need to find out if he's using a viral vector that integrates into the host genome. It should be something like lentivirus or adenoassociated virus. There aren't a lot of other ways to do what he's purportedly doing, so it likely is a viral vector.

    Next, there has really only been one successful treatment with gene therapy. Something for a liver disease. This means what he's doing hasn't made it through safety and efficacy at the FDA, which means there is no "human grade."
    ...
    •   
       


  6. depends on your definition of "human grade". it is available targeted for human genetic code. part of dna therapy being unsuccessful is that a genetic cause isn't as cut and dried as it is in this particular instance. most genetic anomalies are a case of the gene not functioning properly and the therapy is designed to make the gene work correctly. in this case we are talking about silencing a specific well known gene where we have good documented cases of both the gene working normally, and the gene being silent (the human myostatin deficient cases). So him saying there is no human grade is irrelevant, using that sort of logic there never could be human grade - since if you can't produce material to run FDA testing with, how do you ever get FDA approved?

    granted, this doesn't mean i'd try it

  7. listen i have never said anything about this being approved for human use or anything of the sort if you are interested in the results i will post them im not interested in debating someone calling me and idiot this i already know .

  8. Haha. That last part of the sentence threw me for a loop, Black! Dude, you're doing something that very few have done before, so you know all the "gurus" are going to have something to say. It's already been done and I for one and quite interested in hearing/seeing your results.

  9. I just wanna be clear. In no way was i trying to cut BLACK. He is pioneering and puttin his body on the line for a small community of us, not sure if he is loggin this any where else or will be a future study.

    I simply mentioned it on another board and a member had is opinion over there. I posted it in a neutral position on the topic.

    Sorry for causing any stress on you BLACK or anyone else.
    Let this just carry on.

    peace.

  10. no stress homey i just dont want this to turn into a bashing thread thats all

  11. and no i only log on anabolicminds baby

  12. so what exactly does this stuff do?

  13. Quote Originally Posted by grila jujitsu View Post
    so what exactly does this stuff do?
    gets you hyyyooooge. hahaha, ill let one of the more well knowledged guys explain.

    PS-I noticed since i started to come here alot more start to wonder here now too....Easy,Bionic, grila...this is an awesome on topic section of the forum guys. enjoy.

  14. So you do it once every few weeks? How long does it last? Could one do it Once a month or twice a month?

  15. Quote Originally Posted by djbombsquad View Post
    So you do it once every few weeks? How long does it last? Could one do it Once a month or twice a month?

    Read the thread from the start and you will find the answers.

  16. Well so far he only did one but what is optimal?

  17. Quote Originally Posted by djbombsquad View Post
    Well so far he only did one but what is optimal?
    To the best of my knowledge, not enough research has been done for anyone to accurately answer your question.
    Last edited by mexmuscle; 06-23-2008 at 03:48 PM. Reason: Typo

  18. I mean I am looking to try it as well with a stack of pegmgf and ghrp6 even if it was just once a month and that gave some results I am game.

  19. DJ, just chill out and learn something. Why would you be so wiling to do something like this without having anything/one to compare it to/ learn from. Just eat, workout, rest, repeat. Let Black share his experience in peace.

  20. Quote Originally Posted by djbombsquad View Post
    I mean I am looking to try it as well with a stack of pegmgf and ghrp6 even if it was just once a month and that gave some results I am game.

    Do you have any idea what this stuff is? You are scary as **** to me.

    I have something that will get you swole as ****: eating.

    bb

  21. DJ, thats exactly why i dint answer you. It doesnt seem you research anything.
    Also, BLACK seems to know his shyt pretty well. He is doing this as prolly one of the first and currently only...why would you just go do it? Cause its easy? Quick? i want to too but i wont until there are more guys like BLACK and research is out.

    I meant shyt, we are still finding things out about GHRP, Peg, IGF, etc etc...this log hasent and prolly will not even touch the 1st floor of a 1,000 story building.

    PS-I also dint answer casue a simple google search brings up a major amount of info and labs.

    BLACK: Got the PM, i understand man, no drama is better living.

    be easy.

  22. Enough with the jibba-jabba. What's cooking, Black?

  23. Quote Originally Posted by MentalTwitch View Post
    gets you hyyyooooge. hahaha, ill let one of the more well knowledged guys explain.

    PS-I noticed since i started to come here alot more start to wonder here now too....Easy,Bionic, grila...this is an awesome on topic section of the forum guys. enjoy.
    Fo sho bra!

  24. Quote Originally Posted by grila jujitsu View Post
    Fo sho bra!
    yea sorry man, dint meanto sound like a dikc, just i dont wanna miss inform. Its complicated stuff...

  25. alright sorry about not posting yesterday ate a sandwich from a restaraunt and it got me sick feel better today will get back in the gym tommorrow but all is good know just to make this clear i have never said or will i say that this is approved for human use i just have my personal conviction when it comes to myostatin and if this stuff dont work i will tell everyone it dont work but if it do i will say it does peace!
  •   

      
     

Similar Forum Threads

  1. GDF-8
    By foxpharma in forum IGF-1/GH
    Replies: 0
    Last Post: 06-12-2012, 07:46 AM
  2. Replies: 44
    Last Post: 08-18-2011, 06:17 PM
  3. Peg-anti-gdf-8 [myostatin inhibitor]and CJC-1295
    By BLACK747 in forum IGF-1/GH
    Replies: 321
    Last Post: 06-15-2008, 06:27 PM
  4. great article on myostatin protein (GDF-8)
    By french_muscle in forum IGF-1/GH
    Replies: 0
    Last Post: 03-23-2005, 07:06 PM
Log in
Log in