peg mgf... just hype?
- 05-18-2008, 11:14 PM
peg mgf... just hype?
I did not write this, please read and debate.
PEGylated Mechano Growth Factor (PEG MGF)
May 2, 2008
MGF is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle. Natural MGF is made locally and does not travel into the bloodstream. Synthetic MGF is water based and when administered intramuscularly, travels into the bloodstream. MGF is only stable in the blood stream for only a few minutes.
PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF). The PEG acts as a protective coating and the theory here is that this will allow the MGF to be carried through the blood stream without being broken down.
I have to be honest here, and say that in my estimation, PEGylating MGF is basically something a research chemical company did to have a bit of a market with no competition for awhile. That’s not to say that it’s not a decent product, but honestly, in this particular case, I feel that marketing was in the drivers seat with the development of this version of MGF, and science was in the backseat asking “are we there yet?”.
MGF is produced biologically when muscle fibers are broken down through resistance (weight training). It is a potent factor in muscle growth. MGF stimulates muscle growth, creates new muscle fibers, promotes nitrogen retention and increases protein synthesis. This compound is commonly used for overall growth of muscle and to promote growth in body parts that are not up to par with the rest of the user’s physique. Results usually depend on dosage. Fat loss and strength increases are not typically seen with MGF’s use (as they are in IGF-1 use).
The PEG itself is safe for use as it is approved by the US Food and Drug Administration (FDA) and does not react in the body. The PEG is not broken down in the body and excreted (intact) through urine or feces. Any risk associated PEGylated drugs is due to drug itself not the PEG per se.
In a study on older rodents, muscle fiber reduction in their older muscles was found to be attributed to decreased activity of satellite cells. After a certain size was reached, growth ceased. In the presence of MGF, satellite cells became activated and hypertrophy in mature muscles continued.
In experiments where MGF was administered intramuscularly, there was a 20% increase in the weight of the injected muscle fibers within 2 weeks. In further studies, it took 4 months for IGF to cause a 25% increase in muscle mass. MGF was found to be more potent than IGF-1Ea in rapid muscle growth (4).
[Note: This data is on “regular” MGF, not the Pegylated version….we can assume similar results, however]
Although the science looks impressive on paper, in the real world, we see something totally different. While PEGMGF should have theoretically given the athletes who use it better results than regular MGF, it struggles to provide even the same results at a higher dosage (judging from the athletes I have personally spoken to).
So does that mean it’s useless?
No, not at all. Not entirely…
I think that the PEGylation is actually a potentially useful addition to MGF if properly used. If we assume that the PEGylation will extend the life of the MGF in the body somewhat, then we can use it in a very specific manner to help our gains. It is nowhere near as good as regular MGF though, and I wouldn’t use it unless I really had the disposable cash on hand.
I feel that, based on conversations with several athletes and bodybuilders, that PEGMGF is best used in conjunction with (not instead of) regular MGF (and IGF). I feel that if one were to use my Peptides protocol (to read about that in detail, check out the article “Peptides: The Next Frontier in Hypertrophy”), I think that PEGMGF is probably best used on off-days from training, to keep MGF levels elevated and get additional hypertrophy from the longer releasing PEGMGF.
So, along with regular MGF and Lr3IGF-1, if I felt it to be necessary, I might throw in some PEGMGF on off-days from training, to get additional growth (and again, if it were me, I’d probably recommend 400-500mcg of PEGMGF on off days, with a regular dose of 200mcg of regular MGF + 100mgs of Lr3IGF-1 on training days, as per my article).The LORD is my rock, my fortress, and my savior; my God is my rock, in whom I find protection. He is my shield, the power that saves me, and my place of safety.-Psalm 18:2
- 05-19-2008, 02:26 PM
- 05-19-2008, 02:45 PM
I believe he did write it, which means he stole it and misinterpreted the information that he stole. Also, pmgf is good stuff, not as fast acting as igf, no sides to speak of (which sometimes can give the impression that nothing is really happening), have to take higher dosage, over the 8 weeks I used it was very good physique change, not much change in the scale or in strength, although I did actually lose some weight, but noticeable change in the mirror.
05-19-2008, 02:49 PM
The LORD is my rock, my fortress, and my savior; my God is my rock, in whom I find protection. He is my shield, the power that saves me, and my place of safety.-Psalm 18:2
05-19-2008, 02:52 PM
05-19-2008, 03:41 PM
05-19-2008, 03:44 PM
100mcg of IGF-1 post-WO?? That is a huge dose.
M.Ed. Ex Phys
05-20-2008, 01:25 AM
I use both peg and non-peg. imo both work very well but I prefer the non-peg for localised growth and it complements igf very well in this respect.
They both 100% work, I have used both seperately and together.
05-20-2008, 05:58 AM
I finished about a month ago and began an m-drol cycle, so yes I have continued to gain, but that is probably not a fair assessment. From my understanding the gains from the mgf are permanent, they are not a result of a temporary increase in hormones, so you may lose some of the all day fullness, but that should be all. there is no pct needed with this. Dont get me wrong, this was not a size/strength monster, but over the course of 8 weeks ended up with nice physical appearance changes, definitely a situation of gained a little muscle, lost some fat, how much in actual terms, I dont know, but enough where there was a noticeable change in appearance. I have more and will be using for 8 weeks in between cycles as long as available.
05-20-2008, 06:10 AM
back when I was using lots of AAS, but I had never touched peptides I would be lucky to get much heavier than this in the sort of condition im in (8.5-9% bf). I think this shows that over the past 4 months the igf has caused hyperplasia while the mgf has helped to pool extra cells in the muscles.
yes im very impressed with mgf and igf.
05-20-2008, 06:14 AM
I'm with you pumbertot, I have only been taking 120-130 mgs of mdrol per week and have been making nice gains. Peptides between cycles I think can enhance the effectiveness and safety as it appears less anabolics are needed, and at my age and stage of the game, though I still enjoy using anabolics, safety is becoming more important.
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