D-Lys3 Growth Hormone Release Peptide-6
[D-Lys³] GHRP-6 is a Ghrelin and GHRP-6 antagonist (anti-Ghrelin). An antagonist is an opposing or resistant structure in relation and tends to neutralize or impede some action or effect. In this case, the [D-Lys³] GHRP-6 is actually a selective antagonist of the cognate ghrelin receptor, i.e. the GH-secretagogue receptor (GSR).
Growth Hormone - Releasing Hexapeptide-6 (GHRP-6)
GH-releasing hexapeptide (GHRP-6) is a secratogue that stimulates the release of growth hormone (GH) by acting at both hypothalamic and pituitary sites which has been clinically documented in a wide variety of species in vivo and in vitro. GHRP-6 duplicates the way the growth hormone works in the body. In studies it not only has shown to enhance growth hormone levels, but also increased the pulsatile secretory bursts of GH. Another remarkable trait of GHRP-6 is its increase in normal pulsatile physiological secretion by its hypothalamic action. Initial studies with GHRP-6 suggested that this compound acted primarily on the pituitary gland and was absolutely specific for GH release. More recent studies have qualified both of these assumptions. This peptide has been clinically verified to increase GH levels, increase appetite, raise IGF-1 levels, help sleep cycles and more.
A recent study has verified that a 24 hr constant iv infusion of GHRP-6 neurophysiologically (via the central nervous system) activated the GH-IGF-1 axis by activating GH secretory burst mass and amplitude by 7 -to 10-fold and increasing the basal (nonpulsitile) GH secretion by 4.5 fold.
__________________