IGF suspension and stability

  1. IGF suspension and stability


    Per a conversation The Sinner and myself were having; does IGF stay stable when suspended in acetic acid? Or will it be useless?


  2. Stable at room temperature for at least a year.



    Storage of LR3 IGF-1
    *Study conducted by Gropep

    The stability of a liquid solution of LR3IGF-I was monitored for a period of two years at storage conditions of -20 C, +4 C, +22 C, and +37 C. The final concentration of LR3IGF-I was in acetic acid. At various time points, samples were taken and compared to a lyophilized control (stored at 4 C). Listed below are the stability results for each respective storage condition.


    Storage Condition: -20 C (-4 F)
    Biological Potency No Change up to 2 years
    Immunological Activity No Change up to 2 years
    Mobility of Protein No Change up to 2 years
    Elution Profile by reversed phased HPLC No Change up to 2 years

    Storage Condition: +4 C (39.2 F)
    Biological Potency No Change up to 2 years
    Immunological Activity No Change up to 2 years
    Mobility of Protein No Change up to 2 years
    Elution Profile by reversed phased HPLC No Change up to 2 years

    Storage Condition: +22 C (71.6 F)
    Biological Potency No Change up to 2 years
    Immunological Activity No Change up to 2 years
    Mobility of Protein No Change up to 2 years
    Elution Profile by reversed phased HPLC No Change up to 2 years

    Storage Condition: +37 C (98.6 F)
    Biological Potency No Change up to 1 year
    Immunological Activity No Change up to 1 year
    Mobility of Protein No Change up to 1 year
    Elution Profile by reversed phased HPLC No Change up to 1 year

    In conclusion, there is no significant difference in the potency of LR3IGF-I associated with the storage of the liquid formulation when stored at this range of temperatures. There is no evidence for loss of biological activity at any of the tested temperatures when stored as a liquid product. As you can see IGF can be quite stable for even a year at room temperature, but if you want to keep it around for a while then stick it into the fridge. So in my opinion the best way to store LR3 that is suspended in BA (benzoic acid) is in the freezer. The BA won’t allow it to freeze. And if you have it suspended in AA (acetic acid), store it in the fridge.

  3. Cool, thanks for the info.

    I was actually wondering if you got it already suspended in acetic acid. Wouldn't it become useless after travel?
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  4. I have carried mine in my gymbag and it suffered no ill effects.

  5. Quote Originally Posted by RedwolfWV View Post
    I have carried mine in my gymbag and it suffered no ill effects.
    I mean if you get it from a research supplier pre-mixed with acetic acid. Plus how would you know if it was damaged?

  6. 1) Without a fine white powder in the bottom of the vial, you have know way of knowing whether or not there is in fact a peptide in the solution.

    2) You usually do not know how long this has been stored. Dissolving the peptide will shorten the shelf life.

    3) Most importantly, neither you, nor your retailer have any idea what's happening with this package during transit. The study posted was done on storage, where the vial is standing idly. When it gets shipped, you should assume the worst conditions.

    Sometimes vials get shattered because they are so violently handled. There's a big difference between this, and having the vial sit on a shelf or carrying with you in the gym bag.
    Athletic Xtreme Rep
    Bob@athleticxtreme.com
    IFFI
    Ask me about the Athletic Xtreme Product Line

  7. Quote Originally Posted by thesinner View Post
    1) Without a fine white powder in the bottom of the vial, you have know way of knowing whether or not there is in fact a peptide in the solution.

    2) You usually do not know how long this has been stored. Dissolving the peptide will shorten the shelf life.

    3) Most importantly, neither you, nor your retailer have any idea what's happening with this package during transit. The study posted was done on storage, where the vial is standing idly. When it gets shipped, you should assume the worst conditions.

    Sometimes vials get shattered because they are so violently handled. There's a big difference between this, and having the vial sit on a shelf or carrying with you in the gym bag.
    This is all true. I didn't realize you were talking about pre-mixed IGF.

  8. Quote Originally Posted by RedwolfWV View Post
    This is all true. I didn't realize you were talking about pre-mixed IGF.
    Yeah, emo missed an important detail in his original post. (bad kitty!)

    We were talking about a source who was selling pre-mixed. I always tell people NEVER buy premixed peptides.
    Athletic Xtreme Rep
    Bob@athleticxtreme.com
    IFFI
    Ask me about the Athletic Xtreme Product Line
  

  
 

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