CJC-1295 Profile

[TheGame46]

CJC-1295

CJC-1295 is a Long acting GHRH analog. Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF or GHRF) or somatocrinin, is a 44-amino acid peptide hormone produced in the hypothalamus by the arcuate nucleus. GHRH stimulates growth hormone (GH) secretion from the pituitary. GHRH is released in a pulsatile manner, stimulating pulsatile release of GH respectively.

In addition, GHRH also promotes slow-wave sleep .

The active portion of this GRF or GHRH peptide can be found as a 29 amino acid long peptide and is appropriately named GHRH1-29. This pulsatile release of various peptides is due to the negative feedback loop that is part of the hGH axis and controls the amount of hGH that your body produces to keep it in a homeostatic environment. Despite the effectiveness of GHRH to stimulate growth hormone release there are a number of problems associated with using it in vivo. The most noteworthy problem is the half life of the peptide, which has been shown to be ~7 minutes using advanced HPLC technologies that have proven to be very accurate. The reason for this relatively short half life is due to an enzyme called dipeptidylaminopeptidase IV (DPP-IV), which has a high affinity for the amino acids Ala and Pro and in the case of GHRH it cleaves the 1 and 2 positions that consist of Tyr-Ala, creating GHRH3-29, an inactive form of the peptide. To prevent the problems associated with natural GHRH, pharmaceutical companies looked at new ways to increase the half life and bioavailability of these smaller peptides with technologies that work far different than other technologies, such as PEGylation.

CJC-1295 is a synthetic modification of growth hormone releasing factor (GRF) with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively. These substitutions create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation. By applying the Drug Affinity Complex (DAC) technology to GRF, the peptide selectively and covalently binds to circulating albumin after subcutaneous (SC) administration, thus prolonging its half-life. These substitutions are key in increasing the overall half life of CJC-1295 but there lies an even greater reason as to why the half life has been extended from ~7 minutes to greater than 7 days! Bioconjugation is a relatively newer technology that takes a reactive group and attaches it to a peptide, which in turn reacts with a nucleophilic (usually a partially negative molecule) entity found in the blood to form a more stable bond. Albumin, one of the most abundant substances in the human body is chosen as the nucelophile by this particular peptide thanks to a Cys34 thiol group that attracts it. By combining the tetrasubstituted GHRH analogue with maleimodoproprionic acid using a Lys linker, you create a GHRH peptide with a high binding affinity for albumin. Once the CJC-1295 molecule has attached itself to albumin, it is given an extended half life and bioavailability thanks to the albumin preventing enzymatic degredation and kidney excretion. In fact, bioconjugation is so effective that there was less than 1% of CJC-1295 left unreacted in vivo and over 90% was stabilized after subcutaneous injection. This means that you get more of what you paid for working for you. There was no DPP-IV degredation observed on CJC-1295 in any of the various experiments conducted.

Various experiments have been conducted to test the effectiveness of CJC-1295 in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.5-3 fold for 9-11 days after a single injection!

(from the same study) Subcutaneous administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults and was safe and relatively well tolerated, particularly at doses of 30 or 60 µg/kg. There was evidence of a cumulative effect after multiple doses

Not only that but they proved the mean half life to be 5.8-8.1 days and after multiple doses showed mean IGF-1 levels remained above baseline for up to 28 days following! No serious adverse reactions were reported in any group.

Because of the long half-life and stability of the CJC-1295 analog it may only need to be taken 1-2 times per week. However research on GHRH knockout mice showed that e/d injections where superior in increasing GH vs every 48 or 72 hours. “GHRHKO animals receiving daily doses of CJC-1295 exhibited normal body weight and length. Mice treated every 48h and 72h reached higher body weight and length than placebo-treated animals, without full growth normalization.” These mice were treated for 5 weeks.
However the flaw in this study appears to be that the mice treated e/d were receiving a larger dose, so at minimum cjc-1295 is dose dependent. Whether or not a more frequent injection would prove to be beneficial is yet to be determined.

 

[endless]

Sweet. So 30 or 60 µg/kg would translate to what for my 220 lb rat?

 

[TheGame46]

Sweet. So 30 or 60 µg/kg would translate to what for my 220 lb rat?

220lbs is exactly 100kg
so 30X100 would = 3000µg
or 60X100 would = 6000mcg

Because of the seeming build-up of this peptide over time however taking smaller doses for a long period should raise the levels of GH significantly. I have yet to test it myself.

 

[endless]

Thanks. Conversions r not my strong point!! LOl I am going to give this a try.

 

[CDB]

220lbs is exactly 100kg
so 30X100 would = 3000µg
or 60X100 would = 6000mcg

Because of the seeming build-up of this peptide over time however taking smaller doses for a long period should raise the levels of GH significantly. I have yet to test it myself.

What dosing protocol will your hamster be following when you do test it?

 

[TheGame46]

Unfortunantly there is going to be a delay in that b/c of some issues with thei clinical trail, but I plan on using 1-2mg per week possibly split into two doses. I'll prob start low and see how the rats react

 

[TheGame46]

There has been some issues during the CJC clinical trails resulting in what appears to be a temporary hault in the trail. It seems very likely that the trail will be resumed but Innovative Research has decided to hold off on distributing this product for the time being.

Here is the news direct from the pharmaceutical company’s (ConjuChem) press release after the incident

Lipodystrophy study halted after patient death

A Phase II study of a lipodystrophy treatment developed by Canadian
biotech company, ConjuChem, has been halted after the death of a study
participant. The cause of death and its relationship to the study drug -
CJC-1295, a chemically modified version of growth hormone releasing
factor (GRF) also known as DAC:GRF - is currently being investigated.
However, a Phase III study of another Canadian-developed GRF-based
lipodystrophy treatment, Theratechnologies' TH-9507, is continuing.

The multicentre, randomised, placebo-controlled, double-blind Phase II
study of CJC-1295 had only completed enrolling a total of 192
participants with HIV-related visceral obesity at various sites in North
and South America last month. Participants were randomised to receive
once-weekly injections of either a three-week escalating low dose of
CJC-1295 (at 60, 90, 120mcg/kg); a three-week escalating high dose (at
60, 120, 240mcg/kg); or a placebo, and then continue for a further nine
weeks.

The only information released so far by ConjuChem, which stopped the
study on July 17th, is that the participant who died was attending a
study site in Argentina. An unconfirmed, anecdotal report from a trial
participant at a Canadian study site, suggests that the individual
concerned was a man who died a few hours after receiving his eleventh
CJC-1295 injection.

Here is the results of the investigation regarding the death of the man participating in the trail.

ConjuChem provides findings of DAC(TM):GRF HIV Lipodystrophy trial investigation
ConjuChem Biotechnologies Inc. provided findings of its investigation into the death of a patient that occurred in its Phase II clinical trial of DAC(TM):GRF in HIV Lipodystrophy.

MONTREAL, Canada | Aug 08, 2006 | ConjuChem Biotechnologies Inc. (TSX:CJB) provided findings of its investigation into the death of a patient that occurred in its Phase II clinical trial of DAC(TM):GRF in HIV Lipodystrophy. The Company had previously reported on July 14 that a death occurred of a patient in the trial at a clinical site in Argentina. The trial was an international multi-center, randomized, placebo-controlled, double-blind study which had completed enrollment with 192 patients.

Patients were to be administered once-weekly dosing of DAC(TM):GRF for 12 weeks followed by a 6-week follow-up. The deceased patient received the 11th weekly dose on July 13 and approximately two hours later, the patient complained of chest discomfort and an ECG confirmed an acute myocardial infarction; death occurred approximately one hour later.

There is no evidence of any cardiotoxic effects of DAC(TM):GRF in previous preclinical or clinical studies. The attending physician stated that his most likely explanation for the event was the patient had asymptomatic coronary artery disease with plaque rupture and occlusion.

ConjuChem indicated it has terminated the Phase II study and is further evaluating the clinical development strategy of DAC(TM): GRF.


As you can see, it appears that the CJC-1295 peptide had nothing to do with death of the man in the trial. He was an obese AIDs patient as all the other participants. The autopsy showed positive ECG results for the heart attack and further investigation confirmed large amounts of plaque in the arteries as said above leading to the eventual heart attack. It happens everyday unfortunately, especially in the overweight population.

The CJC peptide and the GRF from which it is derived have shown no potential risk factors, and no cardio toxic effects. In fact a competing company was doing a similar study and has continued it trail right through the incident. That alone should show the confidence that this was a totally random, isolated and unrelated incident from the clinical trail of the CJC-1295 peptide. It is still however the wishes of Innovative Research to hold off on releasing the product at least for a short period of time.

 

[CDB]

Correct me if I'm wrong, but with this study design isn't it also possible this guy was getting the placebo all this time and then croaked?

 

[TheGame46]

Correct me if I'm wrong, but with this study design isn't it also possible this guy was getting the placebo all this time and then croaked?

its possible, however ConjuChem has not mentioned any details of what this participant was actually receiving. I find it hard to believe they would have haulted the trial if he died taking the placebo. They definantly would have said something about it to reassure their investors

 

[Maradona]

Sweet. So 30 or 60 µg/kg would translate to what for my 220 lb rat?

No bro is 30mcgs to 60mcgs per kilo meaning 3mgs to 6mgs once or twice per week at least.

Check this out:


J Clin Endocrinol Metab. 2005 Dec 13

Prolonged Stimulation of Growth Hormone and IGF-1 Secretion by CJC-1295, a Long-acting Analogue of Growth Hormone-Releasing Hormone, in Healthy Adults.

Sam L Teichman, Ann Neale, Betty Lawrence, Catherine Gagnon, Jean-Paul Castaigne, Lawrence A Frohman


Context: Therapeutic use of growth hormone-releasing hormone (GHRH) to enhance GH secretion is limited by its short duration of action. Objective: To examine the pharmacokinetic profile, pharmacodynamic effects, and safety of CJC-1295, a long-acting GHRH analog. Design: Two randomized, placebo-controlled, double-blind, ascending dose trials with durations of 28 and 49 days. Setting: Two investigational sites. Participants: Healthy subjects, ages 21 to 61 yr. Interventions: sc administration of CJC-1295 or placebo in one of 4 ascending single doses in the first study and in 2 - 3 weekly or biweekly doses in the second study. Main Outcome Measures: Peak concentrations and area under the curve (AUC) of GH and IGF-1; standard pharmacokinetic parameters for CJC-1295. Results: After a single injection of CJC-1295, there were dose-dependent increases in mean plasma GH concentrations by 2-10 fold for >/= 6 days and in mean plasma IGF-1 concentrations by 1.5- to 3-fold for 9 - 11 days. The estimated half-life of CJC-1295 was 5.8 - 8.1 days. After multiple CJC-1295 doses, mean IGF-1 levels remained above baseline for up to 28 days. No serious adverse reactions were reported. Conclusions: sc administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-1 levels in healthy adults and was safe and relatively well-tolerated, particularly at doses of 30 microg/kg or 60 microg/kg. There was evidence of a cumulative effect after multiple doses. There was evidence of a cumulative effect after multiple doses. These data support the potential utility of CJC-1295 as a therapeutic agent.


I have seen the study also when they refer as to Ugs but I think is the same as MCG, I'll look for a chart to double check.


El Che

 

[TheGame46]

No bro is 30mcgs to 60mcgs per kilo meaning 3mgs to 6mgs once or twice per week at least.

Check this out:


J Clin Endocrinol Metab. 2005 Dec 13

Prolonged Stimulation of Growth Hormone and IGF-1 Secretion by CJC-1295, a Long-acting Analogue of Growth Hormone-Releasing Hormone, in Healthy Adults.

Sam L Teichman, Ann Neale, Betty Lawrence, Catherine Gagnon, Jean-Paul Castaigne, Lawrence A Frohman


Context: Therapeutic use of growth hormone-releasing hormone (GHRH) to enhance GH secretion is limited by its short duration of action. Objective: To examine the pharmacokinetic profile, pharmacodynamic effects, and safety of CJC-1295, a long-acting GHRH analog. Design: Two randomized, placebo-controlled, double-blind, ascending dose trials with durations of 28 and 49 days. Setting: Two investigational sites. Participants: Healthy subjects, ages 21 to 61 yr. Interventions: sc administration of CJC-1295 or placebo in one of 4 ascending single doses in the first study and in 2 - 3 weekly or biweekly doses in the second study. Main Outcome Measures: Peak concentrations and area under the curve (AUC) of GH and IGF-1; standard pharmacokinetic parameters for CJC-1295. Results: After a single injection of CJC-1295, there were dose-dependent increases in mean plasma GH concentrations by 2-10 fold for >/= 6 days and in mean plasma IGF-1 concentrations by 1.5- to 3-fold for 9 - 11 days. The estimated half-life of CJC-1295 was 5.8 - 8.1 days. After multiple CJC-1295 doses, mean IGF-1 levels remained above baseline for up to 28 days. No serious adverse reactions were reported. Conclusions: sc administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-1 levels in healthy adults and was safe and relatively well-tolerated, particularly at doses of 30 microg/kg or 60 microg/kg. There was evidence of a cumulative effect after multiple doses. There was evidence of a cumulative effect after multiple doses. These data support the potential utility of CJC-1295 as a therapeutic agent.


I have seen the study also when they refer as to Ugs but I think is the same as MCG, I'll look for a chart to double check.


El Che

220lbs is exactly 100kg
so 30X100 would = 3000µg or mcg
or 60X100 would = 6000mcg

yes its mcg, and yes we answer'd his ? correctly so what's the "NO bro" for????

 

[CDB]

yes its mcg, and yes we answer'd his ? correctly so what's the "NO bro" for????

My guess is he typed before he thought because he saw what the price would be for a research study over a reasonable time range at that dosage for a 220lb hamster.

 

[Maradona]

Game,

My bad, I missed that part when you answered it, BTW is 3mgs to 6mgs the recommeded dosage once per week?

I just found that information earlier this morning among other useful information about these wonderful peptides.

 

[TheGame46]

Game,

My bad, I missed that part when you answered it, BTW is 3mgs to 6mgs the recommeded dosage once per week?

I just found that information earlier this morning among other useful information about these wonderful peptides.

I quoted that exact study in the profile.
I am now sure what the recommended dose is going to be yet. there has been some debate.

 

[Maradona]

I quoted that exact study in the profile.
I am now sure what the recommended dose is going to be yet. there has been some debate.

Thank you.

 

[opfor101]

so would this require an insulin needle and injected into the subcutaneous fat?

 

[TripDog]

so would this require an insulin needle and injected into the subcutaneous fat?

yep........this stuff gave me the most amazing vivid dreams of my life.....seriously unreal!!!!!!!!

 

[opfor101]

yep........this stuff gave me the most amazing vivid dreams of my life.....seriously unreal!!!!!!!!

hm, how well does this compare to the real thing? (HGH)

and also can you link me to somewhere that shows how to mix this with bacteriostatic water?

 

[TripDog]

hm, how well does this compare to the real thing? (HGH)

and also can you link me to somewhere that shows how to mix this with bacteriostatic water?

yes it's very good stuff...........basicly most places sell it in 2mg(2000mcg)............you inject two full insulin syringes worth of bw into the peptide....this makes it 1000mcg/1cc per full insulin syringe.......so half of an isulin syringe would be 500mcg......a quarter would be 250mcg........if you draw to the 10 it would be 100mcg................if you dilute 2mg's with 2cc's of BW ..i know this gets confusing

 

[opfor101]

yes it's very good stuff...........basicly most places sell it in 2mg(2000mcg)............you inject two full insulin syringes worth of bw into the peptide....this makes it 1000mcg/1cc per full insulin syringe.......so half of an isulin syringe would be 500mcg......a quarter would be 250mcg........if you draw to the 10 it would be 100mcg................if you dilute 2mg's with 2cc's of BW ..i know this gets confusing

oooh ok i got it, thanks alot man!

this stuff looks like a very promising alternative to the more expensive HGH

 

[jcam222]

oooh ok i got it, thanks alot man!

this stuff looks like a very promising alternative to the more expensive HGH

I was hoping that would be the case. After reading through the studies and seeing the dosing required for significant GH release I am no longer sure thats the case. Rigth now it appears as though 2mg is in the $80 range. When you do the math translating dosages @ 60mcg /kg that becomes pretty costly fast.

 

[jcam222]

bump////// anyone using this stuff and any comments on dosage?

Everything I can find for studies shows the need of at least 6mg / week or more.

 

[WARDYLANDRAU]

WELL I JUST GOT THE PRODUCT MY SELF AND IAM GOING TO START ON IT TWICE A WEEK AND I WILL POST THE RESULT TO SEE WHAT HAPPEN , :dl: :dl:

 

[CDB]

WELL I JUST GOT THE PRODUCT MY SELF AND IAM GOING TO START ON IT TWICE A WEEK AND I WILL POST THE RESULT TO SEE WHAT HAPPEN , :dl: :dl:

Hopefully you grow a left hand, and can use it to operate the Caps Lock key on your computer.

 

[TripDog]

Hopefully you grow a left hand, and can use it to operate the Caps Lock key on your computer.

:toofunny:

 

[WARDYLANDRAU]

you are some funny people :clap2:

 

[jcam222]

Hopefully you grow a left hand, and can use it to operate the Caps Lock key on your computer.

LOL now thats some funny ****!!


So from the studies I am reading I would think you need to use like 6mgs / week to get results. Anyone translate them differently??

 

[RichTan]

The cost at 6mg/week comes to about 12,000/yr.
Isn't Jintropin cheaper?

 

[grila jujitsu]

just letting everyone know this stuff is now back in testing phase!!!

 

[papapumpsd]

just letting everyone know this stuff is not back in testing phase!!!

What do you mean?

 

[grila jujitsu]

What do you mean?

the last time this stuff was being tested and put through trials someone died, so they stoped. well now they have begun it again.

-GJJ

 

[papapumpsd]

the last time this stuff was being tested and put through trials someone died, so they stoped. well now they have begun it again.

-GJJ

Ah, gotcha. Thanks for the update.

 

[likkayouth]

just letting everyone know this stuff is not back in testing phase!!!

I'd change "not" to "now" then, I spent the day thinking it is "not" in testing because they found a new side effect.

 

[grila jujitsu]

Ah, gotcha. Thanks for the update.

NP bro!

-GJJ

 

[grila jujitsu]

I'd change "not" to "now" then, I spent the day thinking it is "not" in testing because they found a new side effect.

oh ****! i didnt even see that i did that ! my g-d! sorry!

-GJJ :fart:

 

[datBtrue]

the last time this stuff was being tested and put through trials someone died, so they stoped. well now they have begun it again.

-GJJ

Nothing is listed at: clinicaltrials.gov

Only the unrelated CJC-1134 insulin studies are active.

 

[shimwhittler1]

Hello every one
my name is scott
pleased to make your aquaintances
now thats got all the polite **** out of the way ,
am starting a cjc1295/test enanthate cyle on the 19th of this month ,
will be using 3000mcg of cjc1295 a week , at a 1000 mcg eod
and supplementing this with a weekly shot of test enanthate of about 1000mg .
will be running this for 40 days ,
i will do a daily reprt of my prgress and the sides i get and the effect on my workout . sex life , and apetite , gains etc
do i need to start a new thread? if so how do i do it? or should i just carry on from here?

 

[datBtrue]

do i need to start a new thread?

You need a better protocol. Try adding a GHRP with your unlikely to be CJC-1295 and dosing the combo 3 times per week.

You won't get much out of running test with the ester enanthate only 5.7 weeks. In fact now that I think about it you probably didn't give much thought at all to your protocol because it sure does look unproductive.

Go start your own thread and leave this thread alone. Idiots that want to dose 3000mgs of CJC-1295 per week but run a test ester that doesn't really kick in until week 5 for only 5 and a half weeks deserve their own thread.

 

[walt]

Dat you briefly covered peg MGF would the satellite cells produced by MGF continue to grow with the GRPs producing IGF inside the muscle or would you need to add IGF to insure growth?

 

[datBtrue]

Dat you briefly covered peg MGF would the satellite cells produced by MGF continue to grow with the GRPs producing IGF inside the muscle or would you need to add IGF to insure growth?

Sorry bro but administering MGF will never work no matter what the form.

I don't like to trumpet this information because I don't like to abuse people's illusions but take a look at my post: http://anabolicminds.com/forum/igf-1-gh/98363-dat-s-cjc-23.html#post1638213

If you have any questions ask them in my thread.

 

[shimwhittler1]

thx very much for your kind words ,
the reason i came to forum was to learn and hear what other people had to say ,
i hope when i am alittle more experienced , that i might be a little more polite to a newcomer,
your dead right ofcourse . a faster acting test would be the way forward,
am a little shocked by your unsolicited unfreindliness, was not wat i ws expecting to be honest, i think if your representative of the sort of guys i would be gathering info from on here , then i have sdly made a mistake joining this site , regarda
scott

 

[datBtrue]

i think if your representative of the sort of guys i would be gathering info from on here , then i have sdly made a mistake joining this site , regarda
scott

Is that how you go through life attempting to invoke sympathy instead of doing things correctly.

You think I was harsh to you?

You know absolutely nothing, you say you come here to learn and yet you start off by saying you are going to do a gram of long-estered testosterone for 5.7 weeks.

Oh and yes you have no idea what this CJC-1295 stuff is but you are going to do 1mg every other day.

You aren't here to learn because you already say you are going to start this cycle on the 19th of the month.

You want to tell us day by day what is happening to you?

I'll save you the trouble. Nothing will be happening until your long-estered test kicks in and when it dose...cycle over.

Of course if you are this foolish in planning a cycle your PCT will surely be lacking.

Whatcha want me to say to you Scott?

Seriously the only questions you asked were:

do i need to start a new thread?
if so how do i do it?
or should i just carry on from here?​

Now you say "the reason i came to forum was to learn and hear what other people had to say".

Well you heard what I had to say and I'll shutup now and let you be. Plenty of people will tell you what you want to hear I'm sure.

 

[ray425]

Hey Dat

I really could use some help here:

I have ran some igf-lr3 with sucsess, in the past and I just finished off another cycle.

I just recieved some hexarelin,cjc-1295, and melanotan2.
My issue is can i reconstitute it (hexarelin/cjc-1295) with aa, or should i go with bw, or some other dilutant?
Also could you please suggest how i should dose it (hexarelin/cjc-1295).

I'm 5"5 167lbs 10%bf, and my goals are strength (powerlifting)
I wake up at 7am and train at 8am.

again please help me out here.

 

[datBtrue]

My issue is can i reconstitute it (hexarelin/cjc-1295) with aa, or should i go with bw, or some other dilutant?

BW, never AA.

 

[ray425]

BW, never AA.

thank you

 

[Ralph Wiggum]

If someone is to give a rat/mouse/hamster CJC-1295 & GHRP-6 can they also add human growth Hormone and admisiter all the at once ?

 

[ironclad808]

About to experiment with CJC-1295 to supplement my ongoing back rehab to see if it won't help.

Questions, since this is my first time doing any injection or peptide etc. Is the dosage about 1mg a week? or .5mg twice a week?

What do I mix with the CJC-1295 to make it a fluid, bw? what is bw?, how much of it, and how should I prepare it? i.e.: would I mix a whole 2mg into a syringe and use that syringe twice a week with it in the fridge?

Also I know Acetylcholineesterase inhibitors are legal, and want to mix it in the my supplementation rarely. What oral pills are these? Can I get them at a drug store?

Cheers

 

[bobgenie]

If someone is to give a rat/mouse/hamster CJC-1295 & GHRP-6 can they also add human growth Hormone and admisiter all the at once ?

No. You shouldn't use artificial GH at the same time as CJC and GHRP.

Cheers

 

[datBtrue]

About to experiment with CJC-1295 to supplement my ongoing back rehab to see if it won't help.

Questions, since this is my first time doing any injection or peptide etc. Is the dosage about 1mg a week? or .5mg twice a week?

What do I mix with the CJC-1295 to make it a fluid, bw? what is bw?, how much of it, and how should I prepare it? i.e.: would I mix a whole 2mg into a syringe and use that syringe twice a week with it in the fridge?

Also I know Acetylcholineesterase inhibitors are legal, and want to mix it in the my supplementation rarely. What oral pills are these? Can I get them at a drug store?

Cheers

You likely have modified GRF(1-29) not CJC-1295. Dose 3x per day w/ GHRP-6.

 

[ironclad808]

You likely have modified GRF(1-29) not CJC-1295. Dose 3x per day w/ GHRP-6.

Sounds pricey and not as effective. Currently I only know how to get modified CJC-1295. Is this worthless or not as good as the GHRP? Is real CJC-1295 the type all the ConjuChem experiments were done with even available?