Info on 1x or 2x daily injections

[endless]

Seen this response by a well know IGF guy on another board. Wanted to share.
"All you have to go by is user experience, and since there are very few people on the planet with more user contact than me, I'd like to share some of my info to help the board.

You see, there is no proof that the half-life of LR3 is 12hrs in humans. In fact, most of us old-timers who have used it since it came out agree that it's got about a 30hr half-life. This is determined from experience and not from some study (thank God). I've talked to more IGF users than probably anyone on the planet. And those of us with experience in this have tried both 2x/day and 1x/day dosing, with no difference. You're basically pinning an extra time for nothing. So althought it sounds nice, I know of NOBODY who has seen any difference. The 2x/day theory is one of these new ideas developed by someone with too much theory and not enough practice, and then the good guys who could put out good info don't know better 'cause they think it's the "right" way to do things. "

 

[LakeMountD]

Seen this response by a well know IGF guy on another board. Wanted to share.
"All you have to go by is user experience, and since there are very few people on the planet with more user contact than me, I'd like to share some of my info to help the board.

You see, there is no proof that the half-life of LR3 is 12hrs in humans. In fact, most of us old-timers who have used it since it came out agree that it's got about a 30hr half-life. This is determined from experience and not from some study (thank God). I've talked to more IGF users than probably anyone on the planet. And those of us with experience in this have tried both 2x/day and 1x/day dosing, with no difference. You're basically pinning an extra time for nothing. So althought it sounds nice, I know of NOBODY who has seen any difference. The 2x/day theory is one of these new ideas developed by someone with too much theory and not enough practice, and then the good guys who could put out good info don't know better 'cause they think it's the "right" way to do things. "

Yeah well I have never been a fan of the "old school" lift a rock because it makes you grow mentality. I go by science and frankly I have not, yet, seen anything to support this.

Although I do agree that the half life is slightly higher than 12 hours, I seriously doubt that the half life is even CLOSE to 30 hours. This would mean that only half of the substance has been released after 30 hours and that the full active life of the substance is 60 hours? HIGHLY DOUBTFUL.

Plus you guys are losing yourselves in some cases in this whole half life discussion. You see, IGF is not like various test. esters. It isn't like testosterone propionate where it is a sustained release (in a way) version of testosterone, where after 36-48 hours half of the test has been released, with half still yet to be released. Once the IGF-1 has been injected it goes systemic very quickly and with the amount of IGF-1 receptors in the body, it is also binds very quickly and very efficiently, bidnding stronger to the IGF-1R and binding to the IGFBP's witih an affinity of < 1%. Just because the half life is long does not mean that it will last in your system that long. If that were the case then you could inject one time and the IGF-1 would attach to a receptor, activate it, then continually attach to receptors thereafter and that would last you your entire life. Unfortunately this just isn't the case and IGF-1 gets metabolized and becomes inactive. So thefore you are more than likely not going to see the amount injected the AM last too far into the night or into the next day.

Injecting twice per day keep the levels more regulated, instead of having a bell shaped curve you have an overlapping curve with two bells and allows for more steady serum concentrations of the growth factor.

Until I read something that supports the 30 hour HALF LIFE (not active life, which is different), I will continue to do my injections twice per day.

 

[endless]

Thanks for you reply. Let me ask you something else I have been researching this best I can since my rat is currently on a cycle. If as you say the IGF1 attaches itself very quickly and efficiently. What about IGF1 that will attach itself to the lining of the intestine and cause atrophy of the gut. If everything IGF1 touches will grow and you have a lot of receptors on the lining of the large intestine and inner wall of the abdominal as well. So unless you are training twice a day and injecting immediately PWO. It would seem the IGF1 will more likely seek the path of least resistance and head to the intestinal lining if not injecting PWO. Your thoughts?

 

[LakeMountD]

Thanks for you reply. Let me ask you something else I have been researching this best I can since my rat is currently on a cycle. If as you say the IGF1 attaches itself very quickly and efficiently. What about IGF1 that will attach itself to the lining of the intestine and cause atrophy of the gut. If everything IGF1 touches will grow and you have a lot of receptors on the lining of the large intestine and inner wall of the abdominal as well. So unless you are training twice a day and injecting immediately PWO. It would seem the IGF1 will more likely seek the path of least resistance and head to the intestinal lining if not injecting PWO. Your thoughts?

Actually I just started a thread about it in this forum, check it out.

And just to correct what you said about, IGF-1 attaching to the intestine would not cause atrophy, it would actually make it thicker.

 

[NattyNow]

i prefer 2x a day shots, because 40mcg at once makes me feel hypo, while 2 shots of 20 doesn't. that's my science on it.

 

[NevrEnuf]

Actually I just started a thread about it in this forum, check it out.

And just to correct what you said about, IGF-1 attaching to the intestine would not cause atrophy, it would actually make it thicker.

have you noticed a difference in injecting twice daily over the single dose or have you always done it that way?