Here are the chances of developing antibodies to 192AA

Schwaugher

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This was originally posted by fred9 of Anabolic Review.

"hey was reading about the side-effects of HGH and came along the following:

191AA (Humatrope):
As with all protein pharmaceuticals, a small percentage of patients may develop antibodies to the protein. During the first 6 months of Humatrope therapy in 314 naive patients, only 1.6% developed specific antibodies to Humatrope (binding capacity ≥0.02 mg/L). None had antibody concentrations which exceeded 2 mg/L. Throughout 8 years of this same study, two patients (0.6%) had binding capacity >2 mg/L. Neither patient demonstrated a decrease in growth velocity at or near the time of increased antibody production. It has been reported that growth attenuation from pituitary-derived growth hormone may occur when antibody concentrations are
>1.5 mg/L.

192AA (Protropin):
As with all protein pharmaceuticals, a small percentage of patients may develop antibodies to the protein. Growth hormone antibody binding capacities below 2 mg/L have not been associated with growth attenuation. In some cases when binding capacity exceeds 2 mg/L, growth attenuation has been observed. In clinical studies and postmarketing experience of patients treated with 192 amino acid for injection, approximately 0.4 percent of patients screened for antibody production developed antibodies with binding capacities > 2 mg/L at six months. Out of approximately 26,000 patients who have been treated with 192 amino acid residues , 5 (=0.02%)patients have had growth deceleration associated with binding capacities > 2 mg/L. If growth deceleration is observed that is not attributable to another cause, the patient should be tested for antibodies to growth hormone. Although no evidence exists to indicate that the methionine on the N-terminus of 192 amino acid residues causes antibodies to growth hormone, the physician should consider transferring the patient to somatropin (rDNA origin) for injection, if a patient has antibody binding capacity > 2 mg/L, and has exhibited growth attenuation.


Most 192AA is reconstituted with bac. water which includes BA and most 191AA with sterile water. Some people are sensitive to the benzyl alcohol and develop red welts from it. Its not the 192AA."
 
LakeMountD

LakeMountD

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Cool article, too bad they don't have an article like this for IGF-1 or more specifically LR3 IGF-1. We won't be seeing a study like that for IGF for a long ass time unfortuately.
 

Schwaugher

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Cool article, too bad they don't have an article like this for IGF-1 or more specifically LR3 IGF-1. We won't be seeing a study like that for IGF for a long ass time unfortuately.
Same feelings here bro.
 

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