Okay well after staring at study after study, pissed off at the fact I can't find much on downregulation of IGF-1 receptors I got to thinking. I am posting this here because I am only one person and although I spend hours on this stuff per day I can only see so many studies at once. If you see anything that goes with this subject please post it but I think I might be on to something here. Bear with me .
People are complaining that they aren't seeing results after 4 weeks. I don't believe this is TOTALLY due to downregulation. The main study I found on downregulation stated that in the intestines there was a 50% drop in IGF-1 receptors after rhIGF-1 was administered after time. But serum levels increased 2-3 fold, so this should be enough to cover most of the downregulation. Although you might not have read that study, you probably have read somewhere that supplemenation with LR3 IGF-1 suppresses nautral hGH output. hGH passes through the liver and signals the body to produce IGF-1, which in turn is spliced towards MGF following a workout. After 4 weeks I assumg your natural hGH levels would be quite suppressed compared to normal, especially at these crazy dosages like 80mcg/daily etc. This is your body's natural reaction, it can't just stop making IGF-1, it has to stop producing hGH to do this.
Okay now I am starting to get to my point. As time goes by your body stops producing MGF. MGF is what proliferates (brings in) massive amounts of satellite cells that are fused to muscle and activated (differentiated) by the LR3 IGF-1. HOWEVER, if you don't have much MGF being produced then your LR3 IGF-1 (at the 80mcg or whatever that you are injecting) doesn't have a significant amount of satellite cells to fuse and activate, it is working with a depleted pool of them, making it feel like the effects stop working.
How do I know that this is a good possibility? Well when I was taking it, I saw no difference in how hungry I was on that stuff from the day I started taking it till the 4 week mark. This means that it was still binding weakly to the insulin receptor and was still binding to the IGF-1 receptor. This hunger is different from normal hunger, I would have to get up in the middle of the night and eat a big tablespoon of peanut butter and have some milk or my stomach would be killing me.
Very interesting find here though guys, we might be able to run LR3 longer with MGF use (following my protocol of only injecting MGF on day 1 and day 2, however).
Let me know what you guys think.
People are complaining that they aren't seeing results after 4 weeks. I don't believe this is TOTALLY due to downregulation. The main study I found on downregulation stated that in the intestines there was a 50% drop in IGF-1 receptors after rhIGF-1 was administered after time. But serum levels increased 2-3 fold, so this should be enough to cover most of the downregulation. Although you might not have read that study, you probably have read somewhere that supplemenation with LR3 IGF-1 suppresses nautral hGH output. hGH passes through the liver and signals the body to produce IGF-1, which in turn is spliced towards MGF following a workout. After 4 weeks I assumg your natural hGH levels would be quite suppressed compared to normal, especially at these crazy dosages like 80mcg/daily etc. This is your body's natural reaction, it can't just stop making IGF-1, it has to stop producing hGH to do this.
Okay now I am starting to get to my point. As time goes by your body stops producing MGF. MGF is what proliferates (brings in) massive amounts of satellite cells that are fused to muscle and activated (differentiated) by the LR3 IGF-1. HOWEVER, if you don't have much MGF being produced then your LR3 IGF-1 (at the 80mcg or whatever that you are injecting) doesn't have a significant amount of satellite cells to fuse and activate, it is working with a depleted pool of them, making it feel like the effects stop working.
How do I know that this is a good possibility? Well when I was taking it, I saw no difference in how hungry I was on that stuff from the day I started taking it till the 4 week mark. This means that it was still binding weakly to the insulin receptor and was still binding to the IGF-1 receptor. This hunger is different from normal hunger, I would have to get up in the middle of the night and eat a big tablespoon of peanut butter and have some milk or my stomach would be killing me.
Very interesting find here though guys, we might be able to run LR3 longer with MGF use (following my protocol of only injecting MGF on day 1 and day 2, however).
Let me know what you guys think.