Mechano Growth Factor (MGF) and Insulin-Like Growth Factor-1 (IGF-1) Information Link

Page 3 of 5 First 12345 Last
  1. Re: PEGylated MGF Profile


    Quote Originally Posted by CHAPS
    Is the Igf-1 totally necessary? Or can we just run MGF on it's on?
    You must remember that MGF only increases the number of staelite cells for use. Naturally you body uses another form of IGF very very similar to the systemic LR3 IGF available to then differentiation these new cells into components of adult muscle cells.

    So is IGF necissary, NO I dont hink you have to have it b/c you have your own natural IGF and cna induce IGF productino through training but I think better results may be acheived using both, or using MGF in conjuction with AAS b/c they also induce differentiation

  2. Re: PEGylated MGF Profile


    Since this continues on the sticky info i'm gonna copy this to the thread up there so there isn't scattered info on this all over the place.
    •   
       

  3. Re: Mechano Growth Factor (MGF) and Insulin-Like Growth Factor-1 (IGF-1) Information


    Ok just keep in mind this is unique to the PEGylated version. Could you edit the title so people know please?

  4. Yeah, no foul meant Game. I've just been working hard on narrowing the info lately to make searching much easier.

  5. Your work is brilliant bro... Thanks for sharing! I have so much to read now... seriously thanks
    •   
       


  6. Quote Originally Posted by LakeMountD
    Still the same info. The problem occurred in Dr. Goldspink's older studies. When he first began research on MGF he hypothesized that it was responsible for not only proliferation (brining in of myoblasts) but also for differentiation (activation of these myoblasts). This, however, proved to not be true in newer studies and actually it was wrong to a very large degree as it was found that not only did MGF not differentiate myoblasts but it actually inhibited myoblasts from differentiating (this is his newest hypothesis). They now say that IGF-1Ea is responsible for the differentiation, which is good for all the LR3 IGF-1 users out there. MGF still has its place as something that has a lot of potential, especially with the longer lasting PEGylated version coming out, but it will take much longer to figure out how to use it synergistically with LR3 IGF-1 since it does inhibit differentiation.

    We basically have to determine how we can dose this stuff to where we get a large influx of myoblasts without inhibiting differentiation. I also still believe LR3 IGF-1 and MGF stacked together are the best way to go. With the large amount of IGF-1 we are getting, we need the extra myoblasts and with all the myoblasts being proliferated by the MGF, you are going to want the added anabolism.
    You seem to be the Resident expert on IGF LR3 and MGF. This will be my first cycle of anything. Ive never been a fan of Steroids, but HGH, IGF, and MGF...interest me do to the fact they are natural functions of the body....just magnified. Any thoughts of a virgin stack of any of these or just alone? I was thinking HGH, but if the size comes for IGF LR3...maybe that is the more appropriate route....with a side of MGF? Thoughts?????

  7. I like LR3 IGF-1 the best personally, but then again have never tried hGH as I could never justify the price and the fact cycles have to be run for very long periods of time. Try getting 1-2mg of LR3 IGF-1 and run it at 20mg EOD or 30mg E3D and let me know how you liked it. Hunger should be way up, increased vascularity (through nitric oxide pathways), decrease in fat, slight increase in muscle mass, but this is the foundation that will be laid for later growth. You can also add in PEG-MGF 2x per week if you'd like. Search around professional muscle . com for some dosage schemes, we had some people trying it out over there who loved it.
    PharmD

  8. Quote Originally Posted by LakeMountD
    I like LR3 IGF-1 the best personally, but then again have never tried hGH as I could never justify the price and the fact cycles have to be run for very long periods of time. Try getting 1-2mg of LR3 IGF-1 and run it at 20mg EOD or 30mg E3D and let me know how you liked it. Hunger should be way up, increased vascularity (through nitric oxide pathways), decrease in fat, slight increase in muscle mass, but this is the foundation that will be laid for later growth. You can also add in PEG-MGF 2x per week if you'd like. Search around professional muscle . com for some dosage schemes, we had some people trying it out over there who loved it.
    Thanks.

    IM...but site specific, bilateral or just quad and glute?

  9. Quote Originally Posted by LakeMountD
    I like LR3 IGF-1 the best personally, but then again have never tried hGH as I could never justify the price and the fact cycles have to be run for very long periods of time. Try getting 1-2mg of LR3 IGF-1 and run it at 20mg EOD or 30mg E3D and let me know how you liked it. Hunger should be way up, increased vascularity (through nitric oxide pathways), decrease in fat, slight increase in muscle mass, but this is the foundation that will be laid for later growth. You can also add in PEG-MGF 2x per week if you'd like. Search around professional muscle . com for some dosage schemes, we had some people trying it out over there who loved it.

    Also, I figure ill reconstitute both with AA. Then what do I backload my slin pins with and how much?

  10. Quote Originally Posted by logan22
    Also, I figure ill reconstitute both with AA. Then what do I backload my slin pins with and how much?
    PEG-MGF is water soluble, no need for AA.
    PharmD

  11. Quote Originally Posted by LakeMountD
    PEG-MGF is water soluble, no need for AA.
    Why EOD or E3D? Why not ED?

  12. Quote Originally Posted by logan22
    Why EOD or E3D? Why not ED?
    Receptor endocytosis, aka receptor down regulation . But search the IGF-1 forum for posts by me and there is a thread about why EOD-E3D injections are best.
    PharmD

  13. Quote Originally Posted by LakeMountD
    Receptor endocytosis, aka receptor down regulation . But search the IGF-1 forum for posts by me and there is a thread about why EOD-E3D injections are best.

    Do you have a link to it? I cant find the posting. So if I pin the MGF of Sunday, (everywhere) Then should I wait one day to pin the LR3, then every other day? Would that work

    Sun MGF 250mcg
    Tues, Thurs, Sat LR3 40mcg?

    How does that sound?

  14. Quote Originally Posted by logan22
    Do you have a link to it? I cant find the posting. So if I pin the MGF of Sunday, (everywhere) Then should I wait one day to pin the LR3, then every other day? Would that work

    Sun MGF 250mcg
    Tues, Thurs, Sat LR3 40mcg?

    How does that sound?
    Day one!

    Started today...20/20mcg bilateral Shoulders. So far so good.

  15. i was thinking of doing a somewhat large shot of mgf (say 200mcg) on sunday, working out mon and tues, wen off and then using igf pwo on thur and fri and maybe sat

    i'd be training each bodypart about twice a week--once on the mgf and once on the igf

    i've run a low dose of igf for 3 on, 4-off before and it worked well

    has anyone tried anything similar yet?

  16. I tried 250mcgs peg-MGF once a wk w/ IGF 5 on 2 off @ about 20mcgs. Didnt use IGF on the day OF or the day AFTER the PEG-MGF shot. I got some ok gains w/ it, but I cant help but think Im not getting the most out of that combo. I just felt like there HAD to be a better more effective protocol possible. Because those gains I did make were along w/ Test, tren and GH. Id been on for awhile and my gains had been slowing down more and more despite adjustments in training and diet to get the ball rolling again. The PEG MGF/IGF helped me keep from completely hitting the wall, but I just think theres got to be a better way to cycle them. Im in PCT now and thinking of getting some more IGF and possibly more PEG MGF as well if I can afford it. Still takin the GH of course. Eating clean still(cept yesterday I caved in and had some fries w/ my chicken sandwich, cuz the sandwich left me hungry.) Im thinking of trying either 125mcgs X2/wk or 250mcgs once a wk of PEG MGF with 10-20mcgs E3D of IGF. When you down regulate your IGF receptors w/ 80mcg/ED plus dosages, it just sucks cuz your spending way more money, and only getting results for a couple weeks tops, if that. I've never had the money to burn to try the super high end dosages (some of wich I've heard people say they got good results from) but I've tried 40mcg/ED a few times and up to 60mcg's/ED for short bursts and never noticed anything spectacular. Whats the answer? Taking even MORE? like 120mg's ED? or less like 10mcgs EOD or E3D? I wish I knew. I've heard cases be made for both, but Im still just trying stuff out.

  17. Unicorn...
    Do you have your PM turned off?
    I tried to send you something...

    Ah hell,. .I'll just post it here.
    It's VERY rushed, so maybe I'll edit ti later,.. but I dont want to have to type it again to send it PM style to ya

    hey,.. Just a thought on your MGF/IGF question..

    It looks like you were using a really high dose of peg-mgf,.. and a really small dose of LR3 ed.

    The problem with running the two IMO is that even if you dont shoot both on the same day, there will be some overlap, and the action of IGf can hinder p-MGF.

    The p-mgf will be active for a few days,.. and I dont care what people say, you cant inject something that lives that long without it going systemic. (which is not bad)

    Plus, a 250 mcg dose will run your supply dry quick.

    Suggestion:
    Monday MORNING, take a 150 mcg dose (more is not always better)

    Wednesday NIGHT, take an effective dose of LR3 (about 40-60mcg)

    What your doing with this is allowing the prolifferation to go on for a few days, making new satalite cells that can be used in repair for a few days,... then hopefully, some of that 150 mcg of mgf has "cleared", and you have less floating around by wednesday night.. when you shoot the LR3. This means that the new cells can differentiuate better becasue the LR3 will hinder the MGF if taken too close together.

    Also, this just so happens to also be VERY cost effective, as, doing an additional shot iof either durring the week will cause an overlap of the 2, and hinder the function of the other.. meaning BOTH will be hindered by the other, and cancel out..

    Dont do cardio after working out if possible.. the increase of bloodflow that stays in the muscle will contain a higher concentration of peptide, ... just becasue a higher concentration of blood will be in that muscle. Cardio will make the pump (aka, increased bloodflow/peptide) dissapate some.

    What does this also mean??? I means that a different training protovcal might be helpfull to.
    In short, if you do squats once a week, break it into twice a week. Do them on the day you shoot the MGF, and then again the day you shoot the LR3.
    This will mean that the first time (with mgf) u train them, they get the prolifferation effects, .. and (after you shoot the LR3 ) and also a higher concentration in that group of LR3 to aid in healing with those extra cells the mgf created.
    Basicly, heres the idea:

    The first part of the week-ish (or first half):
    Dose p-MGF
    Your workout routine, try to split into to groups. A monday/Wednesday ( basicly a 2 day split of all groups)

    The second part of the week-ish:
    Dose LR3
    Repeat the same workout as you did Monday and wednesday, but on Thursday and Saturday.

    there was a thread here I read on dogcrap training.. had a link to the style and explination..
    Look into that, and kinda mold their 3 day split, into a 2 day.
    Your favorite excersise the fiorst time around, and your second fav the next.

    Disclaimer:
    Just a suggestion... as I know nothing

  18. Ok, just realized there was a post on this thread (like a week later). Dont know y I didnt get email notification.

    Ok, so XtraFlossy, your saying to try taking MGF and LR3 just once per week each, spaced 2 1/2 days apart?
    I can give that a try.
    Im also taking HGH 8iu's EOD, and was wondering if the natural IGF production increase from that could have an adverse effect on the PEG-MGF's actions.
    I just got some LR3 and I accidentaly left it @ room temp for around 24hours so Im not sure if it's still good.
    Plan to get more PEG-MGF soon. But now Im might need to get more IGF as well. I dont even know how to tell if it's still good.
    (Dang, and I JUST BOUGHT it too.) DOH!!

    I posted a thread asking about how long the IGF could survive @ room temp. (Still cant believe I forgot to put it back in the fridge.)
    THanx XF.

  19. Honestly, I dont know about the room temp thing. I think I remember somneone saying they kept it in a drawer for a month and it was still good. Try it and see.
    As for the hgh, I wouldnt think that would hinder, least at NORMAL level ranges. I wouldn't know at what point using GH would produce enough IGf-1 to cause any interference. BUT, I would think that it shouldn't effect it (compared to LR3). remember, IGF-1 has a very short half life, especially compared to LR3

  20. Cool.

    Im still using the MGF and IGF that got left out overnight.
    It's hard to tell how well the stuff is working anyway, so I probably wont know for awhile if it's still good. But Im thinking that the LR3 should at least be good, maybe the MGF too but who knows.
    Im going to just continue my EOD GH dosing of 8IU's.
    Started humalog again recently. Im in my 3rd wk of PCT, and happened to have a few bucks around, so Im having some fun with it.

  21. is there any interest in the MD magazine article this month on MGF? If so I will scan and post. Don't want to bother if no one cares though.

  22. Quote Originally Posted by Goat
    is there any interest in the MD magazine article this month on MGF? If so I will scan and post. Don't want to bother if no one cares though.

    I allready read it. It was a good read, but nothing we here at AM didnt allready know for months.

  23. Quote Originally Posted by Goat
    is there any interest in the MD magazine article this month on MGF? If so I will scan and post. Don't want to bother if no one cares though.
    Yeah, I'd love to see it.

  24. Can I pegylate MGF myself ? How can I ?

  25. Quote Originally Posted by Geebee View Post
    Can I pegylate MGF myself ? How can I ?
    Put it through a pegylator capacitor.

  26. Quote Originally Posted by Goat View Post
    Put it through a pegylator capacitor.
    I suppose it's a joke !!!
    When I was a child, my father was telling me about sausage-trees.

  27. These results are based on actual transplantation of the DNA coding for the peptides. This is a permanent effect and much more potent than IM injections of the peptide itself. You will not see a 20% increase in muscle mass through IM injections as claimed above.
    ...What exactly does that mean?

  28. Quote Originally Posted by prodigy06 View Post
    ...What exactly does that mean?
    donīt whre you got that from, but it means that the dna code for the peptide was introduced into the cell-dna, so that itīs transscyrpted by the mRNS and thus expressed
    by the cells selves, yielding in a more or less permanent MGF production.

    There was a study on IGF transfection in cartilage with artificially induced damage to show, that its usability in regenreation of damaged cartilage.

    BTW what is a good dose for MGF -250mcg? I used to see good results with 60mcg LR3 IGF-1, if thatīd be evne closely comparable.

  29. Quote Originally Posted by Fastflight View Post
    donīt whre you got that from, but it means that the dna code for the peptide was introduced into the cell-dna, so that itīs transscyrpted by the mRNS and thus expressed
    by the cells selves, yielding in a more or less permanent MGF production.

    There was a study on IGF transfection in cartilage with artificially induced damage to show, that its usability in regenreation of damaged cartilage.

    BTW what is a good dose for MGF -250mcg? I used to see good results with 60mcg LR3 IGF-1, if thatīd be evne closely comparable.
    I got the quote from the very bottom of the post at the start of this thread. In the post they say "nevertheless, it has been shown that MGF is a potent inducer of muscle hypertrophy in experiments in which the cDNA of MGF was inserted into a plasmid vector and introduced by intramuscular injection. This resulted in a 20 % increase in the weight of the injected muscle within 2 weeks" then at the bottom it says "These results are based on actual transplantation of the DNA coding for the peptides. This is a permanent effect and much more potent than IM injections of the peptide itself. You will not see a 20% increase in muscle mass through IM injections as claimed above."
    I'm confused on that
  •   

      
     

Similar Forum Threads

  1. Replies: 7
    Last Post: 11-22-2008, 09:51 PM
  2. Replies: 7
    Last Post: 07-01-2008, 01:42 PM
  3. Replies: 1
    Last Post: 10-30-2007, 08:15 PM
  4. Replies: 1
    Last Post: 04-15-2006, 12:01 AM
  5. Replies: 26
    Last Post: 12-28-2005, 12:21 PM
Log in
Log in