des (1-3) igf-1

[LakeMountD]

Anyone know if it is even available as of yet?

It is basically a chemically altered form of regular LR3-IGF-1. The alteration comes in at the end of the chain where they break off the portion of the amino acid that binds to igf-1-bp3 (binding protein 3). This makes it immune to being bound. Your body actually can 'accidently' make it during burnout sets. Acidosis (caused by lactic acid on burnout sets) sometimes inadvertently truncates the end of the IGF-1 molecule and creates des (1-3) igf-1. It is said to be 1000% more anabolic than igf-1.

 

[xtraflossy]

I have found a site that can engineer any chemical process end result (for a lack of a better explination). So, I assume it can be obtained.
But honestly, it sounds like you are describing LR3-IGF-1. Dont they chop off the end of the chain, substatue argine for glutamine or somethin

 

[LakeMountD]

I have found a site that can engineer any chemical process end result (for a lack of a better explination). So, I assume it can be obtained.
But honestly, it sounds like you are describing LR3-IGF-1. Dont they chop off the end of the chain, substatue argine for glutamine or somethin

I am not positive but I believe des (1-3) igf-1 and lr3-igf-1 are two different entities. They both can't be bound to bp3 but I am not sure if they are the same. You may be right.

 

[xtraflossy]

I am not positive but I believe des (1-3) igf-1 and lr3-igf-1 are two different entities. They both can't be bound to bp3 but I am not sure if they are the same. You may be right.

The only reason I say that is because I was reading and came accross something I thought was different.... Turned out not to be, but you would never have guessed by the name. But, it was the "1000 times" that stuck out.

If the IGF is kept from being bound, then what keeps it "alive" or active? Or are you thinking more along the lines of site-specific applications?:think:

I am fairly interested in the direction your going though... If ya wanna post a little something...

 

[dertynasty]

gropep sells it:jaw: 5mg for $9000.

Ur right man, just added 1mg to my cart.. came out to $3,025 GOOD LORD THATS ALOTA MONEY. Lets just pray mgf works like it should.

"DES (1-3) IGF-1 (NOT THE SAME AS IGF-1)
Most athletes have heard of IGF-1 (Insulin like growth factor-1) and the amazing anabolic effects it has been reported to have upon protein based tissue such as muscle. Des (1-3) IGF-1 is over 10 times (1000%) more anabolic than IGF-1. Now that is amazing!!
IGF-1 is actually produced from both Insulin and growth hormone in the liver and other tissues. IGF-1 is made up of 70 amino acids in a chain. Well, when a clever chemist removes the last 3 amino acids in the IGF-1 chain (the N-terminal tri-peptide) it becomes Des (1-3) IGF-1 and 1000% plus more anabolic. Why? IGF-1 circulates through our blood stream and tissue 24 hours a day, 7 days a week. Unfortunately, most of the IGF-1 is inactive because it is bound by another protein called (get this) IGF-1 Binding Protein-3, or IGF-1-BP-3 for short. Since bound hormones can not fit into and trigger a receptor-site, the majority of circulating and muscle IGF-1 can not trigger an anabolic stimulus. Like tons of cellulite in a porno movie (who watches those?) there is little good stuff happening. However, when IGF-1 is altered and becomes Des (1-3) IGF-1 the binding protein IGF-1-BP-3 can not bind to it and it is totally active. Another reason Des (1-3) IGF-1 is so potent is its unique ability to fit into lactic acid altered IGF-1 receptor sites. (YUP) When we train we burn carbohydrates as a fuel to make cellular ATP. When cells switch to this ATP pathway, the by-product is Lactic Acid. This is of course the cause of most of the burn we feel during intense or higher rep sets. Well, the lactic acid build-up is called acidosis, and it destroys the shape of some receptor-sites for period of time. Therefore some anabolic/anti-catabolic hormones have difficulty merging with their respective receptor- site and triggering a response (such as even unbound IGF-1). Not so with Des (1-3) IGF- 1, the super growth factor. It fits into the IGF-1 receptor-site even after acidosis. Des (1- 3) IGF-1 is unbound, over 10 times more potent than IGF-1, and it picks receptor-site locks. Too bad it has only a few minute active-life.
Did you know that our body's make Des (1-3) IGF-1 naturally? Most un-informed individuals claim other wise, but it is true. When an athlete trains lactic acid builds up in muscle tissue. As we know, there is always IGF-1 / GH present in the blood stream and tissues (including muscle) from prior work-outs and other metabolic factors. That lactic acid burn triggers IGF-1/GH secretion from both prior and present work-outs. Unfortunately, lactic acid destroys some of the IGF-1 present in muscles being trained. But wait, this is good too!
Lactic acid also cuts (truncates) the last 3 amino acids off the 70 amino acid chain of "some" of the surviving IGF-1 and creates Des (I-3) IGF-1. So acidosis increases GH/IGF-1 production in the liver, "unbinds" IGF-1 locally in the muscle being trained (burned), destroys some of the IGF-1, and converts some IGF-1 into Des (I-3) IGF-1. Huh, good deal. And the synthetic form of this super anabolic stuff is beginning to show up on the black market more frequently."

 

[LakeMountD]

Ur right man, just added 1mg to my cart.. came out to $3,025 GOOD LORD THATS ALOTA MONEY. Lets just pray mgf works like it should.

"DES (1-3) IGF-1 (NOT THE SAME AS IGF-1)
Most athletes have heard of IGF-1 (Insulin like growth factor-1) and the amazing anabolic effects it has been reported to have upon protein based tissue such as muscle. Des (1-3) IGF-1 is over 10 times (1000%) more anabolic than IGF-1. Now that is amazing!!
IGF-1 is actually produced from both Insulin and growth hormone in the liver and other tissues. IGF-1 is made up of 70 amino acids in a chain. Well, when a clever chemist removes the last 3 amino acids in the IGF-1 chain (the N-terminal tri-peptide) it becomes Des (1-3) IGF-1 and 1000% plus more anabolic. Why? IGF-1 circulates through our blood stream and tissue 24 hours a day, 7 days a week. Unfortunately, most of the IGF-1 is inactive because it is bound by another protein called (get this) IGF-1 Binding Protein-3, or IGF-1-BP-3 for short. Since bound hormones can not fit into and trigger a receptor-site, the majority of circulating and muscle IGF-1 can not trigger an anabolic stimulus. Like tons of cellulite in a porno movie (who watches those?) there is little good stuff happening. However, when IGF-1 is altered and becomes Des (1-3) IGF-1 the binding protein IGF-1-BP-3 can not bind to it and it is totally active. Another reason Des (1-3) IGF-1 is so potent is its unique ability to fit into lactic acid altered IGF-1 receptor sites. (YUP) When we train we burn carbohydrates as a fuel to make cellular ATP. When cells switch to this ATP pathway, the by-product is Lactic Acid. This is of course the cause of most of the burn we feel during intense or higher rep sets. Well, the lactic acid build-up is called acidosis, and it destroys the shape of some receptor-sites for period of time. Therefore some anabolic/anti-catabolic hormones have difficulty merging with their respective receptor- site and triggering a response (such as even unbound IGF-1). Not so with Des (1-3) IGF- 1, the super growth factor. It fits into the IGF-1 receptor-site even after acidosis. Des (1- 3) IGF-1 is unbound, over 10 times more potent than IGF-1, and it picks receptor-site locks. Too bad it has only a few minute active-life.
Did you know that our body's make Des (1-3) IGF-1 naturally? Most un-informed individuals claim other wise, but it is true. When an athlete trains lactic acid builds up in muscle tissue. As we know, there is always IGF-1 / GH present in the blood stream and tissues (including muscle) from prior work-outs and other metabolic factors. That lactic acid burn triggers IGF-1/GH secretion from both prior and present work-outs. Unfortunately, lactic acid destroys some of the IGF-1 present in muscles being trained. But wait, this is good too!
Lactic acid also cuts (truncates) the last 3 amino acids off the 70 amino acid chain of "some" of the surviving IGF-1 and creates Des (I-3) IGF-1. So acidosis increases GH/IGF-1 production in the liver, "unbinds" IGF-1 locally in the muscle being trained (burned), destroys some of the IGF-1, and converts some IGF-1 into Des (I-3) IGF-1. Huh, good deal. And the synthetic form of this super anabolic stuff is beginning to show up on the black market more frequently."

That quote is directly out of CME.

 

[dertynasty]

That quote is directly out of CME.

we have a winner:clap2:

 

[LakeMountD]

gropep sells it:jaw: 5mg for $9000.

Hahaha that is INSANE lol. I don't want to be big THAT bad lol.

I am curious though. They say it is 10 times more anabolic, however, how would this make much of a difference when we are talking about IGF. IGF, from what I thought, wasn't really something you took due to its anabolism but instead because of its ability to cause hyperplasia, etc. I thought it was more of a growth signal more than it was anabolism. I am assuming they used the wrong word when they said 10 times more anabolic and meant 10 times as "potent" since it doesn't get binded to BP3.

I was under the impression that LR3 IGF-1 couldn't bind to BP3 though.

 

[Grunt76]

I was under that same impression... <-- Call that a bump

 

[LakeMountD]

I was under that same impression... <-- Call that a bump

Well I just read somewhere, not sure if it is true or not, that IGF has a stronger effect than insulin at replenishing muscle glycogen and the nice thing about it is it ONLY has this effect at the myofibrils and NOT the adipocytes. So saying that, since insulin itself is considered anabolic, I guess you could say that IGF is more anabolic although that term has to be used very loosely.