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GH or IGF

max-rot98

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I ran a search trying to find info on what would be better for bone healing. Found a little info but nothing great. So for those of you that have used either or are pretty educated in this please help.

The majority of what I found states igf but that is mostly in regards to tendons and tissue. Again I am only concerned with which one would be better for broken bones. I figured gh would be better but I am not sure.
 
no studies or anything but i based on what i've read, i would think GH does more for bone growth and thickness. i remember reading someplace about how if you take growth during your adolescent years that you'll become taller, but after that point growth will make you thicker (bones and such). i don't have **** to back that up but just what i read somewhere. i know for me, growth has helped my pec become stronger that it was before (reoccuring shoulder/pec tie-in injury).
 
Calcif Tissue Int. 2003 Sep;73(3):258-64. Related Articles, Links
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Local anabolic effects of growth hormone on intact bone and healing fractures in rats.

Andreassen TT, Oxlund H.

Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark. [email protected]

The local effects of rat growth hormone (rGH) injected at the surfaces of intact tibial diaphyses and healing tibial diaphysial fractures were investigated in 10-month-old female rats. Intact diaphysial bones: rats were injected daily for 14 days with vehicle, 2 microg rGH, or 20 microg rGH at the surface of the right tibial diaphysis. After 10 days of injection the animals were labeled with calcein. At the rGH-injected location, increased external diaphysial bone dimensions and increased calcein-labeled area were seen, and the responses to rGH were dose dependent. The new bone formed at the periosteal surface was woven bone. At the opposite left tibia, no systemic effect of rGH was found. rGH did not influence body weight changes during the treatment, or muscle mass or serum IGF-I at the end of the treatment. Healing diaphysial fractures: a closed fracture was made in the right tibial diaphysis, and stabilized by medullary nailing. The fractures were tested after 21 days and 98 days of healing. During the first 21 days of healing, all rats were injected daily with either vehicle or 20 microg rGH at the surface of the fracture line. In the 21-day healing rGH group, ultimate load, ultimate stiffness, external callus dimensions, and external callus volume of the fractures were increased. rGH did not affect body weight changes during this healing period or serum IGF-I at the end of the healing period. In the 98-day healing rGH group, ultimate load was still increased compared with the vehicle group, although a ninefold increase took place in the vehicle group between days 21 and 98 of healing. External callus dimensions of the fractures were increased in the rGH group, whereas body weight changes during the healing period were not affected.

PMID: 14667139 [PubMed - indexed for MEDLINE]
 
Bone. 2003 Oct;33(4):628-37. Related Articles, Links
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Homologous growth hormone accelerates bone healing--a biomechanical and histological study.

Kolbeck S, Bail H, Schmidmaier G, Alquiza M, Raun K, Kappelgard A, Flyvbjerg A, Haas N, Raschke M.

Trauma and Reconstructive Surgery, Medical Faculty Charite, Virchow Clinic, Humboldt University, Berlin, Germany. [email protected]

The purpose of this study was to prove whether homologous growth hormone has a beneficial effect in the early phase of bone healing. Therefore the left tibias of 24 Yucatan micropigs were osteotomized and stabilized by plate fixation. The treatment group (12 animals) received 100 microg of recombinant porcine growth hormone (rpGH)/kg body w/day sc, whereas the control pigs (12 animals) received 1 ml sodium chloride as placebo. After a healing period of 4 weeks the animals were sacrificed and destructive torsional testing was performed. For histological evaluation 6 microm serial slices of the tibiae were stained with von Kossa. The total area of callus formation (CA) and the mineralized bone area (BA) were quantified by image analysis. The fraction of mineralized bone tissue within the callus area, the bone density (BD), was calculated as follows: BD = (BA/CA) x 100. Torsional failure load was 91% higher and torsional stiffness 61% higher in the treatment group than in the control group (P < 0.05). The histomorphometric measurements revealed an advance for the CA (GH: 127.6 +/- 38.9 mm(2); placebo: 75.9 +/- 50.7 mm(2); P < 0.005) as well as for the BA (GH: 89.3 +/- 25.8 mm(2); placebo: 55.9 +/- 38.5 mm(2); P < 0.001) for the GH-treated animals in comparison to the control animals. The BD was similar in both groups (GH: 70.6 +/- 8.4%; placebo: 74.0 +/- 6.24%; P = 0.28). These data indicate that administration of homologous GH stimulates callus formation and ossification in the early phase of bone healing, which consequently results in an increased mechanical strength and stiffness.

PMID: 14555268 [PubMed - indexed for MEDLINE]
 
1: Clin Orthop Relat Res. 1991 Mar;(264):295-301. Related Articles, Links

The stimulating effect of growth hormone on fracture healing is dependent on onset and duration of administration.

Bak B, Jorgensen PH, Andreassen TT.

Department of Connective Tissue Biology, University of Aarhus, Denmark.

The effect of onset and duration of growth hormone administration on the biomechanical properties of healing rat tibial fractures was investigated after 40 days of healing. Biosynthetic human growth hormone, 2.7 mg/kg body weight/day, was given in two daily injections to three groups of rats: (1) for the entire healing period; (2) for the first 20 days; and (3) for the last 20 days of healing. Three corresponding groups of control rats were injected with saline. In Group 1, maximum load and stiffness of the healing fractures increased to 165% and 175%, respectively, compared to the control group. In Group 2, maximum load, stiffness, maximum stress, and energy absorption at maximum load increased to 222%, 175%, 171%, and 247%, respectively, compared to the control group. In Group 3, no statistically detectable effects were found. The results show that growth hormone stimulates fracture healing both when given during the first part of the healing period and when given during the entire healing period.

PMID: 1997248 [PubMed - indexed for MEDLINE]
 
Thank you Beelz. I thought gh would be the thing to take so we'll find out.
Aprpreciate the studies you found. Thanks again big guy!:clap2:
 
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