Sleep also affect letpin levels and TSH....
Summary for patients in:
[size=+1]
Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite.[/size]
Spiegel K,
Tasali E,
Penev P,
Van Cauter E.
University of Chicago, Chicago, Illinois, USA.
BACKGROUND: Total sleep deprivation in rodents and in humans has been associated with hyperphagia. Over the past 40 years, self-reported sleep duration in the United States has decreased by almost 2 hours. OBJECTIVE: To determine whether partial sleep curtailment, an increasingly prevalent behavior, alters appetite regulation. DESIGN: Randomized, 2-period, 2-condition crossover clinical study. SETTING: Clinical Research Center, University of Chicago, Chicago, Illinois. PATIENTS: 12 healthy men (mean age [+/-SD], 22 +/- 2 years; mean body mass index [+/-SD], 23.6 +/- 2.0 kg/m2). MEASUREMENTS: Daytime profiles of plasma leptin and ghrelin levels and subjective ratings of hunger and appetite. INTERVENTION: 2 days of sleep restriction and 2 days of sleep extension under controlled conditions of caloric intake and physical activity. RESULTS: Sleep restriction was associated with average reductions in the anorexigenic hormone leptin (decrease, 18%; P = 0.04), elevations in the orexigenic factor ghrelin (increase, 28%; P < 0.04), and increased hunger (increase, 24%; P < 0.01) and appetite (increase, 23%; P = 0.01), especially for calorie-dense foods with high carbohydrate content (increase, 33% to 45%; P = 0.02). LIMITATIONS: The study included only 12 young men and did not measure energy expenditure. CONCLUSIONS: Short sleep duration in young, healthy men is associated with decreased leptin levels, increased ghrelin levels, and increased hunger and appetite.
Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin.
Spiegel K,
Leproult R,
L'hermite-Baleriaux M,
Copinschi G,
Penev PD,
Van Cauter E.
Department of Medicine, MC 1027, University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA.
Sleep plays an important role in energy homeostasis. The present study tests the hypothesis that circulating levels of leptin, a hormone that signals energy balance to the brain, are influenced by sleep duration. We also analyzed associations between leptin and sympathovagal balance, cortisol, TSH, glucose, and insulin under different bedtime conditions. Twenty-four-hour hormonal and glucose profiles were sampled at frequent intervals, and sympathovagal balance was estimated from heart rate variability in 11 subjects studied after 6 d of 4-h bedtimes (mean +/- sem of sleep duration during last 2 d: 3 h and 49 +/- 2 min) and after 6 d of 12-h bedtimes (sleep: 9 h and 03 +/- 15 min). A study with 8-h bedtimes was performed 1 yr later (sleep: 6 h and 52 +/- 10 min). Caloric intake and activity levels were carefully controlled in all studies. Mean levels, maximal levels, and rhythm amplitude of leptin were decreased (-19%, -26%, and -20%, respectively) during sleep restriction compared with sleep extension. The decrease in leptin levels was concomitant with an elevation of sympathovagal balance. The effects of sleep duration on leptin were quantitatively associated with alterations of the cortisol and TSH profiles and were accompanied by an elevation of postbreakfast homeostasis model assessment values. Measures of perceived stress were not increased during sleep restriction. During the study with 8-h bedtimes, hormonal and metabolic parameters were intermediate between those observed with 4-h and 12-h bedtimes. In conclusion, sleep modulates a major component of the neuroendocrine control of appetite.
J Clin Endocrinol Metab. 2000 Aug;85(8):2685-91.
Related Articles, Links
[size=+1]
Twenty-four-hour leptin levels respond to cumulative short-term energy imbalance and predict subsequent intake.[/size]
Chin-Chance C,
Polonsky KS,
Schoeller DA.
Department of Medicine, University of Chicago, Illinois 60637, USA.
Leptin plays a vital role in the regulation of energy balance in rodent models of obesity. However, less information is available about its homeostatic role in humans. The aim of this study was to determine whether leptin serves as an indicator of short-term energy balance by measuring acute effects of small manipulations in energy intake on leptin levels in normal individuals. The 12-day study was composed of four consecutive dietary-treatment periods of 3 days each. Baseline (BASE) [100% total energy expenditure (TEE)] feeding, followed by random crossover periods of overfeeding (130% TEE) or underfeeding (70% TEE) separated by a eucaloric (100% TEE) washout (WASH) period. The study participants were six healthy, nonobese subjects. Leptin levels serially measured throughout the study period allowed a daily profile for each treatment period to be constructed and a 24-h average to be calculated; ad libitum intake during breakfast "buffet" following each treatment period was also measured. Average changes in mesor leptin levels during WASH, which were sensitive to energy balance effected during the prior period, were observed. After underfeeding, leptin levels during WASH were 88 +/- 16% of those during BASE compared with 135 +/- 22% following overfeeding (P = 0.03). Leptin levels did not return to BASE during WASH when intake returned to 100% TEE, but instead were restored (104 +/- 21% and 106 +/- 16%; not significant) only after subjects crossed-over to complementary dietary treatment that restored cumulative energy balance. Changes in ad libitum intake from BASE correlated with changes in leptin levels (r2 = 0.40; P = 0.01). Leptin levels are acutely responsive to modest changes in energy balance. Because leptin levels returned to BASE only after completion of a complementary feeding period and restoration of cumulative energy balance, leptin levels reflect short-term cumulative energy balance. Leptin seems to maintain cumulative energy balance by modulating energy intake. I could go on... and on... but I think that should prove that lower leptin and thyroid stimulating hormone levels for someone trying to stay lean and healthy are NOT a good thing. Conclusion: Sleep more!
). Since that time, I in all honestly am lucky to get more then 5-5.5 hours of sleep a night mostly because of we need sometime at the end of the day to talk, I need to pick her kids up from baby sitters, do family like things etc.. On Week ends, I get about 7-8. It's the one area of my training that worries me, as it's a key ingredient of train/eat/sleep.
