From IBE site. "When IGF-1 levels are increased, protein synthesis is increased along with amino acid absorption. IGF-1 will function as a source of energy and mobilize fat for use as energy in adipose tissue. IGF-1 response within lean tissue will prevent insulin from transporting glucose across cell membranes. The result of this activity will be a switch within the cells to burning fat as a source of energy, therefore causing significant fat cell decrease"