The following is an exert on MGF from Author L Rea's book.
"Many studies support my belief that IGF-1, whether of endogenous or exogeneous origin, was the primary SYNERGY hormone responsible for muscular growth and repair. I have had several clients who had below average endogeneous test production and average or above IGF-1 levels.
Yet most experienced gains near equal to other natural bodybuilders. I believe this was due to the synergy between IGF-1 and another hormone called Mechano growth factor, or MGF.
MGF is a hormone locally produced in muscles in response to both stretching and overload training, especially due to heavy overload training. This is true only when there is an atmosphere of extensive muscle fiber damage from high weight trumatic sets. The more severe the heavy stimuli, the more MGF the muscle fibers produce. This is quite similar to localized endogeneous IGF-1 production and stimuli.
Recent studies used engineered genes that increased the expression of MGF in mice muscles. The researchers injeceted the genes and found a 20% muscle mass increase in only 14 days. MGF is far more potent than IGF-1 or GH.
Currently, MGF research is geared toward treating various muscle diseases and weakened musculature occurring due to the lack of exercise and age. Researchers have found humans who continue to train as they age, may be able to maintain optimum MGF production.
However, some surgery or disabled patients cannot. For this reason, researchers are experimenting with MGF and IGF-1 and or GH for muscle wasting prevention. For now, watch out for big mice.
I think its safe to theorize that MGF will be one of the next genetic expanding chemistries for most sports. I have noted two genetic research companies are presently manufacturing MGF for research use. Soon it will show up on the black market I think.
By the way, researchers have also already created a testing protoccol to detect MGF use."
I'll see what else I can dig up on MGF. As for IGF-1, there are many threads in this section that tell you just about everything you could want to know about IGF-1, including source. Try the muscle-research forum as well, and check out their site muscle-research.com But to briefly recap what I know from memory, IGF-1 is a protien hormone synthesized in the liver and in muscles from the remanents of GH in the presence of insulin. It is responsible for many of the effects associated with GH use including hyperplasia, or muscle fiber splitting. It is similar to insulin in structure and shares many of the same receptor sites. The rIGF-1 variety, is extremely fragile and even loud noises or less than optimal temperatures can deactivate it. It has a very short active life (I think around 20 or 30 minutes) after administration, and is commonly dosed from 60 to 120mcgs a day devided into 3-5 doses, for steadier plasma levels. However, the Long R3 IGF-1 variety (thats the one I use) is much more stable, and less prone to deactivation. LR3 also has a much longer active life, and is stronger mcg for mcg. common LR3 IGF-1 doses are 40-80 mcgs a day (some people take it in devided doses, some take it all at once.) I take at least part of my daily dose right after my workout. If your sensitive to hypoglycemia, you might want to eat some carbs around the same time you take your shot. I've yet to have that problem. BTW IBE has developed an orally active IGF-1 that people on theese boards have been raving about. I've yet to try it, but user feed back seems to be strong. Some of the people whove tried it had allready tried LR3 and said that IBE's product (its called Oratropin-1) was comparable. I cant vouch for it until Ive tried it myself, but it looks like it might actually work. In the past if anyone had claimed to have an oral form of IGF (or any protien hormone for that matter) I would have thought they were full of it, because, protien hormones, being made of amino acids and only functioning when intact in a specific order/formation, would be easily quelled by protylytic enzymes in the stomach. But some reputable cats have tried it with great success, and its a bit cheaper than the injectable to boot. Just something to consider.
