[BuiltOne]

Just curious about this subject. Can someone elaborate?

Never exceed 120mcg in one day. IGF1 can cause serious gastrointestinal problems such as tumors intestinal swelling diarrhea and vomiting.

I know that it is a matter of mcg/dose, but starting at say 30-40mcg, will these things come into effect at all? Is it more related to how steroids can cause cancer due to doseage?

[Matthew D]

IGF-1 can aggravate already existing precancerous cells formations.. but we have not heard of anything going on with lower dosage in the 30-60 range or at least I have not
But what is up with 120 mcg in one day? Where did you find that?

[BuiltOne]

The sticky bro. You guys need to update that shiot. Because the first one also says to start out with 80mcg or something. If someone can find an up to date addition that would be great. I know that there is good info in there still but for some people they will go by that to a tee and I think that could be less productive. Am I jsut rambling let me know. It might be the Sulbutiamine and Anavar combo LOL.

[Matthew D]

I will work on it ASAP.. just haven't had a lot of time lately

[einstein1905]

Yeah, like was mentioned, IGF-1 won't "cause" cancer, but it does increase the rate of epithelial cell turnover a great deal.....with each cell division, there is potential for some aspect of a cancerous cell to develop (via mutation), so increasing the rate of cell division increases the potential for cancer, albeit caused by some other factor, to develop. Also, if there are cancerous cells present, then speading up mitosis will increase their proliferation as well.....many cancers "feed" off on increased IGF-1 levels (breast cancer is one of these among others).

[BuiltOne]

Thank you for looking into it Matt. I am just worried because I have ulcerative colitis and there is a greater potential for colon cancer with this. I just can't win I swear.

[OVRT]

Raises and interesting question as to the effect of IGF-1 on pre-existing gyno. Does it exacerbate the tumor growth.

In addition, what is the effect of IGF-1 on the prostate when one is suffering from BPS? Is there an increase in the PSA level in response to IGF-1?

-OT

[einstein1905]

Originally Posted by OVRT

Raises and interesting question as to the effect of IGF-1 on pre-existing gyno. Does it exacerbate the tumor growth.

In addition, what is the effect of IGF-1 on the prostate when one is suffering from BPS? Is there an increase in the PSA level in response to IGF-1?

-OT

IGF-1 will exacerbate gyno, as several people will note that taking a week off of training will cause their gyno to reduce slightly....this is because the large excercise-induced spikes of GH (and therefore IGF-1) are not present during that time. In fact, nolva has been hypothesized to treat breast cancer by also reducing IGF-1 expression in mammary fat pads as well as preventing ER-mediated growth

[BuiltOne]

Sounds like trouble to me. So have any of you guys heard of these problems first hand?

[einstein1905]

Originally Posted by BuiltOne

Sounds like trouble to me. So have any of you guys heard of these problems first hand?

I've used several mgs of IGF-1 with no ill effects, and I'll continue to do so.

[porch monkey]

einstein1905, obviously youre make gains using it or you would'nt be, what do you rate it at 1-10 ? Have you had any troubles keeping it stable? was it hard to find?

[einstein1905]

Originally Posted by porch monkey

einstein1905, obviously youre make gains using it or you would'nt be, what do you rate it at 1-10 ? Have you had any troubles keeping it stable? was it hard to find?

The problem is.......too many people hear others praise IGF-1 and can't wait to try it.......most will be disappointed. compared to AAS, it's a joke. That's not the point though. For those with a relatively "matured" physique, you know how hard it is to gain compared to your early AAS days. The addition of IGF-1 to your cycle can make a significant difference....those that really know their bodies will be able to best appreciate this, but those with 1 or 2 cycles under their belt won't have a good baseline for comparison. Even alone, IGF-1 is impressive to me. being able to drop bf and add LBM (albeit very little) is an impressive feat. it's also an excellent addition to pct to maintain a positive nitrogen balance w/o AAS

[Billy the kid]

Originally Posted by einstein1905

it's also an excellent addition to pct to maintain a positive nitrogen balance w/o AAS

[size]

Originally Posted by einstein1905

In fact, nolva has been hypothesized to treat breast cancer by also reducing IGF-1 expression in mammary fat pads as well as preventing ER-mediated growth

True, and another good reason to use nolvadex to prevent gyno.

[Billy the kid]

While we are on the subject of cancer.

My wife was diagnosed with severe cervical dysplasia this week. She is going to have some precancerous spots removed from her cervix.
Do i need to worry about genital secretions of IGF or even AAS bathing the spots on the cervix? The reason i ask is because of the following paragraph.

What causes cervical dysplasia?

HPV is one of the most frequent causes of cervical dysplasia. In addition, cigarette smoking has been found to be a cause. Women who smoke concentrate the chemicals nicotine and cotinine into their cervix, which harms the cells. Men also concentrate these chemicals into their genital secretions, and can bathe the cervix with these chemicals during intercourse. Male partners of women with cervical dysplasia should not smoke. Some nutritional deficiencies also can cause cervical dysplasia. The National Cancer Institute recommends that women consume five servings of fresh vegetables or fruits each day. If you cannot do this, consider taking a daily multivitamin with antioxidants such as Vitamin E or beta-carotene.

[einstein1905]

Originally Posted by Billy the kid

While we are on the subject of cancer.

My wife was diagnosed with severe cervical dysplasia this week. She is going to have some precancerous spots removed from her cervix.
Do i need to worry about genital secretions of IGF or even AAS bathing the spots on the cervix? The reason i ask is because of the following paragraph.

What causes cervical dysplasia?

HPV is one of the most frequent causes of cervical dysplasia. In addition, cigarette smoking has been found to be a cause. Women who smoke concentrate the chemicals nicotine and cotinine into their cervix, which harms the cells. Men also concentrate these chemicals into their genital secretions, and can bathe the cervix with these chemicals during intercourse. Male partners of women with cervical dysplasia should not smoke. Some nutritional deficiencies also can cause cervical dysplasia. The National Cancer Institute recommends that women consume five servings of fresh vegetables or fruits each day. If you cannot do this, consider taking a daily multivitamin with antioxidants such as Vitamin E or beta-carotene.

No, AAS are not sequestered in ejaculate, nor would there be any appreciable amount of IGF-1.

[OVRT]

Originally Posted by Billy the kid

While we are on the subject of cancer.

My wife was diagnosed with severe cervical dysplasia this week. She is going to have some precancerous spots removed from her cervix.
Do i need to worry about genital secretions of IGF or even AAS bathing the spots on the cervix? The reason i ask is because of the following paragraph.

What causes cervical dysplasia?

HPV is one of the most frequent causes of cervical dysplasia. In addition, cigarette smoking has been found to be a cause. Women who smoke concentrate the chemicals nicotine and cotinine into their cervix, which harms the cells. Men also concentrate these chemicals into their genital secretions, and can bathe the cervix with these chemicals during intercourse. Male partners of women with cervical dysplasia should not smoke. Some nutritional deficiencies also can cause cervical dysplasia. The National Cancer Institute recommends that women consume five servings of fresh vegetables or fruits each day. If you cannot do this, consider taking a daily multivitamin with antioxidants such as Vitamin E or beta-carotene.

Hey BILLY...

In the hopes of calming your fears, cervical dysplasia is fairly common and quite treatable. The fact that the irregular cells were discovered before they had manifested themselves into full blown cervical cancer, is a good thing. My ex-gf was diagnosed with cervical dysplasia and she opted for the more elaborate surgery to remove a large amount of tissue. It has been 2 years and she has had normal pap smears every time (4x per year).

[BuiltOne]

All good info here, thanx guys. PCT seems to be the most interesting to me or at least running it towards the end of a cycle.