I wanna know this too.
Check this thread
http://www.elitefitness.com/forum/showthread.php?t=329619
I'm waiting for Dr.Jmw to answer me regarding t3/hg/muscleloss
Regarding to Jmw you can stay on 50mcg every morning for "at least 6 months".
That "whacked" guy is holding his own.....although plagiarising me:
"IGF-1 LR3 is IGF-1 with a point mutation to increase binding affinity and also an additional stretch of amino acids, which do not affect its binding to IGF receptors but which renders it unsusceptible to being bound by IGFBPs, so the insulin to increase IGFBPs and therefore half-life is really only for regular IGF-1, which is obsolete in the days of LR3 availability. However, since insulin and IGF-1 share much homology, as do their receptors, the use of the two together has the effect of upregulation of their own and each other's receptors (initially) when introduced at supraphysiological levels, which then increases the potency of each, per se. For that reason, if no other, a 30 day cycle is best suited for using the two together.
Resistance training causes upregulation of IGF receptors in the muscles worked, so shooting post workout into the muscles just worked creates, statistically/kinetically, the best opportunity for effects in that/those muscles. it's not clear for how long IGF receptors are upregulated, so shootin gin the AM on an off day into the muscles worked the previous workout is what I do. Alternatively, you could JUST shoot the combo ob workout days. LR3 is also going to cause feedback inhibition and suppress endogenous GH release, so 2x/day administration provides nearly a 24 hour suppressive effect on GH release."
I'm not a member over there, so i won't respond, but I also saw someone mention that you "build up antibodies to LR3 over time".........that's about as wrong as wrong can be. If LR3 elicits an immune response, it's all or nothing. The immune system isn't utilized to regulate serum levels of proteins. ANY immune response specific to LR3 will completely thwart its effects.....both at the time and at any time in the future that it's reintroduced.