my opinion, leave the GHRP alone and put the money towards CJC-1295, if you have extra $ then get more CJC-1295. You get so much more bang for the buck with straight up CJC and huperzine -a, also much more quality look rather than just a big waterlog who is hungry
GHRP-2 is better for cutting, as GHRP-6 usually increases hunger alot. I use along side with slin when im bulking. Works magic! haha (not recommended for beginners, the slin part).
If anyone is intersted in adding in huperzine a, I would recommend doing so after a month or so of GHRP/CJC use. Mainly because you'll be able to identify if anything negative comes up from the addition and secondly you'll notice a hell of a difference which i think is important to be able to see how powerful the huperzine can be (which should be dosed around 100mcg - 250mcg)
Look at dats studies. Cjc alone raises the baseline of gh, or trough. you get no pulse or actual raise till you send a signal with one of the ghrp's. I have been reading on his forum and others for the longest time. Dat and everyone else recommends them together for their synergy. You may get some benefit off cjc alone, but not like you would off both. All medical studies, in fact you would get more off ghrp alone then cjc.
We need only to examine the results of the normal test subjects from three oft-cited studies that established the relevant protocol.
In the first study "Inhibition of growth hormone release after the combined administration of GHRH and GHRP-6 in patients with Cushing's syndrome", Alfonso Leal-Cerro..., Clinical Endocrinology 1994, 41 (5) , 649–654, three different peptide/peptide combinations were used.
GHRH was administered alone at 100mcg. This resulted in area under the curve (AUC) measured for 120 minutes of GH secretion of 1420 ± 330.
GHRP-6 was administered alone at 100mcg. This resulted in area under the curve (AUC) measured for 120 minutes of GH secretion of 2278 ± 290.
GHRH plus GHRP-6 was administered together at 100mcg each. This resulted in area under the curve (AUC) measured for 120 minutes of GH secretion of 7332 ± 592.
As a single dose these results show that GHRP-6 is about twice as effective as GHRH.
The synergy between GHRH & GHRP-6 is clearly evident as co-administration resulted in twice the benefit of the additive values of single doses of the two peptides.
The second study is the one that established the saturation dose for these peptides often used in other studies. "Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone ", CY Bowers..., J. Clin. Endocrinol. Metab., Apr 1990; 70: 975-982.
In that study GHRH at a dose of 1.0 microgram/kg was administered alone and then together with various doses of GHRP-6 (0.1, 0.3, and 1.0 microgram/kg). They found that the submaximal dosages of 0.1 and 0.3 microgram/kg GHRP-6 plus 1 microgram/kg GHRH did have the effect of stimulating GH release synergistically.
However the larger dose of 1 mcg/kg of GHRP-6 was found to be the saturation dose when used in combination w/ 1 mcg/kg of GHRH.
It is also noteworthy that serum prolactin and cortisol levels rose about 2-fold above base levels only at the 1 microgram/kg dose of GHRP-6 and not at the submaximal dosages.
The final study, "Preserved Growth Hormone (GH) Secretion in Aged and Very Old Subjects after Testing with the Combined Stimulus GH-Releasing Hormone plus GH-Releasing Hexapeptide-6", Micic D..., J Clin Endocrinol Metab. 1998 Jul;83(7):2569-72 is fascinating for several reasons.
By reference to citation it is noted that "GHRH plus GHRP-6 (both at saturating dose) is nowadays considered the most potent stimulus of GH secretion in man being able to restore the GH secretion in states associated with chronic blockade of somatotroph activity (as in obesity)...it elicits a near-normal GH discharge in obesity, in patients with hypothyroidism and in patients with type 2 diabetes mellitus."
This particular study examined the effects of combined administration of GHRH, immediately followed by GHRP-6 in a group of very old subjects (age higher than 75 yr), as compared with both normal adults (less than 40 yr) and aged subjects (age 46–65 yr). The dosing levels used were 90mcg of GHRH followed by 1mcg/kg of GHRP-6.
All the subjects had a positive GH secretory response to the combined administration with no differences observed between men and women. However the group comprising the very old had the highest level of GH release followed by the group comprising the aged subjects with the "less than 40 yr group" experiencing a substantial rise but not as high as the other two groups.
The study concluded that the lack of side-effects & safety of the protocol and the discovered lack of age-related decline in the "GHRH-GHRP-6-mediated GH release opens the possibility of using it as a therapeutical tool to revert some deleterious manifestations of aging in man."
People use GHRP in addition to their cycles because it provides a synergy, and provides results that are better than a GHRP or GHRH alone.
I just don't see the point in pinning 3g of GHRH a week. Sure you could do it...but why? when it's PROVEN that a smaller combination of GHRH/GHRP is going to be better (and it's not proven that 3g of GHRH will give you better results.....).
GHRP is also CHEAPER than GHRH. Don't know where you're shopping at, but I can get 5mg of GHRP-2 for 5 bucks cheaper than a 2mg bottle of a GHRH.
We don't take lightly to outlandish claims around here Coors. Please be ready to back up your position if you make such a claim.
Don't take this the wrong way either, I'm more concerned about educating you and others more than anything else.
But someone's gotta lay the smack down.
All in the studies.
Things got confusing and kind of heated in here - anyone want to help me out with some cliff's notes, if I admit I'm just being super duper lazy?
After you've been on a month or two, add in huperzine a. Just be careful, this stuff will really make the peptides kick HARD. So start with a small dose 100mcg for a week and assess results.
The only time I would recommend GHRP-6 is when you're looking for a large increase in hunger. GHRP-2 is a 2nd gen peptide and has less sides (no hunger, prolactin, or cortisol increase) where the GHRP-6 has all of these to a slight degree.
any info on the saturation dose if you are over 200lbs? Is it in dat's massive thread?
I was dosing Huperzine-A as well, but I was injecting pre-workout since I have carbohydrates post workout.
I'm glad I was informed about Hex's propensity to desensitize quickly.
Would you estimate that this combo you listed above would be more dynamic and fast acting than real hgh? I have a couple sources, but just can't, and probably never will, justify the necessary investment.
PS: I'm over 230
yeah bro I feel you I'm over 230 myself and because I am not sh1tting out money, I cannot justify the cost of exogenous GH. I really enjoyed the combo of GHRP and cjc. I found them to be synergistic.. And not calling out coors but results will vary from person to person, considering that we are not part of a controlled lab study and we all use different sources, which could have different concentrations at any given time. Gear and peps can always be overdosed, underdosed, bunk or old, so there is hardly ever a guarantee on anything. You seem to be really opinionated and there's NOTHING wrong with having that assertive quality yet a lot of claims made on this board (not calling you out by any means) are rather subjective.
I personally liked the pep combo, and found that the fact that it is non suppressive (for the most part) gives it an edge over exogenous GH.
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