GHRP-6 worth it?
- 04-04-2011, 09:37 AM
- 04-04-2011, 11:35 AM
Look at dats studies. Cjc alone raises the baseline of gh, or trough. you get no pulse or actual raise till you send a signal with one of the ghrp's. I have been reading on his forum and others for the longest time. Dat and everyone else recommends them together for their synergy. You may get some benefit off cjc alone, but not like you would off both. All medical studies, in fact you would get more off ghrp alone then cjc.
04-04-2011, 12:05 PM
Borrowed from Datbtrue
We need only to examine the results of the normal test subjects from three oft-cited studies that established the relevant protocol.
In the first study "Inhibition of growth hormone release after the combined administration of GHRH and GHRP-6 in patients with Cushing's syndrome", Alfonso Leal-Cerro..., Clinical Endocrinology 1994, 41 (5) , 649–654, three different peptide/peptide combinations were used.
GHRH was administered alone at 100mcg. This resulted in area under the curve (AUC) measured for 120 minutes of GH secretion of 1420 ± 330.
GHRP-6 was administered alone at 100mcg. This resulted in area under the curve (AUC) measured for 120 minutes of GH secretion of 2278 ± 290.
GHRH plus GHRP-6 was administered together at 100mcg each. This resulted in area under the curve (AUC) measured for 120 minutes of GH secretion of 7332 ± 592.
As a single dose these results show that GHRP-6 is about twice as effective as GHRH.
The synergy between GHRH & GHRP-6 is clearly evident as co-administration resulted in twice the benefit of the additive values of single doses of the two peptides.
The second study is the one that established the saturation dose for these peptides often used in other studies. "Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone ", CY Bowers..., J. Clin. Endocrinol. Metab., Apr 1990; 70: 975-982.
In that study GHRH at a dose of 1.0 microgram/kg was administered alone and then together with various doses of GHRP-6 (0.1, 0.3, and 1.0 microgram/kg). They found that the submaximal dosages of 0.1 and 0.3 microgram/kg GHRP-6 plus 1 microgram/kg GHRH did have the effect of stimulating GH release synergistically.
However the larger dose of 1 mcg/kg of GHRP-6 was found to be the saturation dose when used in combination w/ 1 mcg/kg of GHRH.
It is also noteworthy that serum prolactin and cortisol levels rose about 2-fold above base levels only at the 1 microgram/kg dose of GHRP-6 and not at the submaximal dosages.
The final study, "Preserved Growth Hormone (GH) Secretion in Aged and Very Old Subjects after Testing with the Combined Stimulus GH-Releasing Hormone plus GH-Releasing Hexapeptide-6", Micic D..., J Clin Endocrinol Metab. 1998 Jul;83(7):2569-72 is fascinating for several reasons.
By reference to citation it is noted that "GHRH plus GHRP-6 (both at saturating dose) is nowadays considered the most potent stimulus of GH secretion in man being able to restore the GH secretion in states associated with chronic blockade of somatotroph activity (as in obesity)...it elicits a near-normal GH discharge in obesity, in patients with hypothyroidism and in patients with type 2 diabetes mellitus."
This particular study examined the effects of combined administration of GHRH, immediately followed by GHRP-6 in a group of very old subjects (age higher than 75 yr), as compared with both normal adults (less than 40 yr) and aged subjects (age 46–65 yr). The dosing levels used were 90mcg of GHRH followed by 1mcg/kg of GHRP-6.
All the subjects had a positive GH secretory response to the combined administration with no differences observed between men and women. However the group comprising the very old had the highest level of GH release followed by the group comprising the aged subjects with the "less than 40 yr group" experiencing a substantial rise but not as high as the other two groups.
The study concluded that the lack of side-effects & safety of the protocol and the discovered lack of age-related decline in the "GHRH-GHRP-6-mediated GH release opens the possibility of using it as a therapeutical tool to revert some deleterious manifestations of aging in man."
04-04-2011, 12:15 PM
People use GHRP in addition to their cycles because it provides a synergy, and provides results that are better than a GHRP or GHRH alone.
I just don't see the point in pinning 3g of GHRH a week. Sure you could do it...but why? when it's PROVEN that a smaller combination of GHRH/GHRP is going to be better (and it's not proven that 3g of GHRH will give you better results.....).
GHRP is also CHEAPER than GHRH. Don't know where you're shopping at, but I can get 5mg of GHRP-2 for 5 bucks cheaper than a 2mg bottle of a GHRH.
We don't take lightly to outlandish claims around here Coors. Please be ready to back up your position if you make such a claim.
Don't take this the wrong way either, I'm more concerned about educating you and others more than anything else.
But someone's gotta lay the smack down.
04-04-2011, 12:19 PM
04-04-2011, 12:25 PM
04-04-2011, 05:05 PM
Things got confusing and kind of heated in here - anyone want to help me out with some cliff's notes, if I admit I'm just being super duper lazy?
04-04-2011, 08:50 PM
04-04-2011, 10:21 PM
04-04-2011, 10:39 PM
After you've been on a month or two, add in huperzine a. Just be careful, this stuff will really make the peptides kick HARD. So start with a small dose 100mcg for a week and assess results.
The only time I would recommend GHRP-6 is when you're looking for a large increase in hunger. GHRP-2 is a 2nd gen peptide and has less sides (no hunger, prolactin, or cortisol increase) where the GHRP-6 has all of these to a slight degree.
04-04-2011, 10:59 PM
04-05-2011, 08:39 AM
04-05-2011, 10:15 AM
04-05-2011, 05:16 PM
I was dosing Huperzine-A as well, but I was injecting pre-workout since I have carbohydrates post workout.
I'm glad I was informed about Hex's propensity to desensitize quickly.
Would you estimate that this combo you listed above would be more dynamic and fast acting than real hgh? I have a couple sources, but just can't, and probably never will, justify the necessary investment.
PS: I'm over 230
04-05-2011, 06:54 PM
yeah bro I feel you I'm over 230 myself and because I am not sh1tting out money, I cannot justify the cost of exogenous GH. I really enjoyed the combo of GHRP and cjc. I found them to be synergistic.. And not calling out coors but results will vary from person to person, considering that we are not part of a controlled lab study and we all use different sources, which could have different concentrations at any given time. Gear and peps can always be overdosed, underdosed, bunk or old, so there is hardly ever a guarantee on anything. You seem to be really opinionated and there's NOTHING wrong with having that assertive quality yet a lot of claims made on this board (not calling you out by any means) are rather subjective.
I personally liked the pep combo, and found that the fact that it is non suppressive (for the most part) gives it an edge over exogenous GH.
NTBM Line @ NUTRAPLANET
All posts are for entertainment purposes only.
Need2slin... NOM NOM NOM :yup:
04-05-2011, 07:02 PM
I would expect it to be more dynamic and fast acting than HGH. Just speculation though, and I'm not 100 percent positive as i've never seen the study.
But peptides are legal, cause a natural rise in GH, and are cheaper. I just don't see the need to both with black market HGH when peptides are just an overall better alternative.
04-05-2011, 10:08 PM
04-05-2011, 11:18 PM
Hey dark half, where are you getting huperzine? pm me. also where can I find out more info on it. Thanks. Supposedly ghrp-2 and cjc1295 mod are the strongest stack you can get, with the least side affects. I have been on it for about a month so far, with ipamorelin at night. Liking my results so far.
04-06-2011, 09:06 AM
04-06-2011, 05:14 PM
Dark Half you mention adding Huperzine after a month or so "Just be careful, this stuff will really make the peptides kick HARD. So start with a small dose 100mcg for a week and assess results." For my clarification you mean 100mcg a week or per day. Sorry I am ignorant to subject I am just trying to soak all this in.
04-06-2011, 08:02 PM
04-06-2011, 08:26 PM
Thank you. Also I know your not a fan of people not doing there research but I have and still need to clear one thing up. I am running a GHRP-2 and CJC1293 experiment. The CJC1293 is listed as Mod 1-29 on site im purchasing from they list 1295 w/ dac as other option. So my question is : is CJC1293 = CJC1295 w/o dac? Again sorry for ignorance.
04-06-2011, 10:29 PM
Guys, read this article. It explains pretty much everything about GH surges and pulses on just CJC-1295 with huperzine a. You dont need the GHRP with it, you can get plenty of results with just CJC and huperzine. I'd rather get my CJC-1295 dose up at a decent whack than run "a little of this and a little of that" not to mention, sticking yourself 2-3x/day just ****ing blows, if you have any kind of life this is just ridiculous to do!!
04-07-2011, 08:42 AM
There are various types of GHRH's. The only GHRH to consider is tetra-substituted CJC-1295 / CJC-1295(without DAC) / modGRF(1-29). They are all the same thing but with a different name.
GRF(1-29) is produced and sold as a drug called Sermorelin. It has a short-half life measured in minutes. If you prefer analogies think of this as a Testosterone Suspension (i.e. unestered).
To increase the stability and half-life of GRF(1-29) four amino acid changes where made to its structure. These changes increase the half-life beyond 30 minutes which is more than sufficient to exert a sustained effect which will maximize a GH pulse. This form is often called tetrasubstituted GRF(1-29) (or modified) and unfortunately & confusingly mislabeled as CJC-1295. If you prefer analogies think of this as a Testosterone Propionate (i.e. short-estered).
Note that some may also refer to this as CJC-1295 without the DAC (Drug Affinity Complex).
Frequent dosing of either the aforementioned modified GRF(1-29) or regular GRF(1-29) is required and as previously indicated works synergistically with a GHRP.
04-07-2011, 08:52 AM
Whereas my post a page back has cited references and data graphs from actual studies, disproving your original and ongoing claims of what you think works best (when I have science proving what we now know to best)
Sticking yourself 2-3x per day isn't that hard to factor in to your life. 1 when you wake up, 1 after you work out, and 1 before going to sleep. Takes less than 60 sec per shot.