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Igfbp-3?

steveo

New member
Is IGFBP-3 (Insulin Like Growth Factor Binding Protein-3) the same as IGF-1 LR3? if anyone can help me i would greatly appreciate it.
 
No. IGFBP3 is the binding protein that makes increased circulating IGF-1 usless. Long R3 is structurally altered form of IGF-1 to resist this binding protein making it suitable for use.
 
i don't know what that means but on another board another igf retailer is going to be selling this as a better compound . , is it ?
 
WATERLOGGED said:
i don't know what that means but on another board another igf retailer is going to be selling this as a better compound . , is it ?
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pretty sure bobo just said it wasn't
 
what bobo said is this will make igf-1 in your system useless. You add more igf-1 lr3 igf1bp is what makes it not effective.
 
why do you say that


CROWLER
 
well the majority of the igf-1 in your body gets bound the the 1gf1bp3 which is similar to shbg with test. since the bound igf-1 cant fit into its receptor due to the binding protien, its useless until your body removes the protien. however when you cleave off the last 3 aminos in the igf-1 chain (you body can also do this naturally) you then have des(1-3)igf-1. the reson why its so much more potent than igf-1 is becuase the binding protien cannot attach to it at all making it all active and on top of that it can fit into igf-1 receptors that have been altered due to lactic acid, something that igf-1 has trouble with when the receptor gets destroyed by acidosis. the only reason why i dont think we see much of des(1-3)igf-1 ( i hate typing that) is becuase i dont know if anyone has been able to extend its active life like they have with igf-1 which is onnly a few minutes.
 
BMW said:
well the majority of the igf-1 in your body gets bound the the 1gf1bp3 which is similar to shbg with test. since the bound igf-1 cant fit into its receptor due to the binding protien, its useless until your body removes the protien. however when you cleave off the last 3 aminos in the igf-1 chain (you body can also do this naturally) you then have des(1-3)igf-1. the reson why its so much more potent than igf-1 is becuase the binding protien cannot attach to it at all making it all active and on top of that it can fit into igf-1 receptors that have been altered due to lactic acid, something that igf-1 has trouble with when the receptor gets destroyed by acidosis. the only reason why i dont think we see much of des(1-3)igf-1 ( i hate typing that) is becuase i dont know if anyone has been able to extend its active life like they have with igf-1 which is onnly a few minutes.
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Hmmm...I was with you until you mentioned lactic acid. It's a pretty well known among physiologists these days that lactic acid is actually an acid salt that releases no protons. As such, lactic acid does not induce acidosis but rather ATP hydrolysis does, with lactic acid actually acting as a buffer, utilizing a proton in its formation. Do you have a source where you got this from?
 
IGFBP3 is what you need to prolongue IGF-1 ciculating time if you go to supra-physiologicla levels via injection.

Since normal IGF-1 has a half life of only a few minutes it´s more effective when shot with the IGFBP and IGFBP-3 is what u need for making IGF-1 stable so it´s activity is longer I guesa something about 6 hours.

It´s now being tested for medical use in AIDS-wasting and other deseases.
 
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