[Kruger]

Acnemans Insulin FAQ

what is insulin?

Insulin is a hormone secreted by the beta cells of the pancreas that controls the metabolism and cellular uptake of sugars, proteins, and fats. As a drug, it is used principally to control diabetes. Insulin is not a steroid.

What type of insulin should I use for bodybuilding?

Humulin R and Humulog are the only insulins I recommend because they act fast and are out of the body fastest(this makes them the safest). I have never used Humalog but understand that aside from quicker onset and half-life it is essentially the same.

Why do I want to use insulin?

Insulin has been called "Anabolicus Maximus" by some gurus of the bodybuilding world. Insulin can give you greater gains than you have ever had using anabolics alone. Insulin, in combination with androgens and resistance exercise, may trigger maturation of satellite muscle cells (small, more or less useless cells that are held in reserve, which do not contribute to muscular strength) into mature muscle cells that do contribute to muscular size and strength. How freakin cool is that. Hyperinsulinemia has been shown to stimulate protein synthesis in isolated limb infusion experiments , these anabolic properties seem to be the result of insulin binding to IGF-1 receptors.

If insulin is so great why aren't all diabetics huge?

Diabetics have a disease and use insulin to replace endogenous insulin that they cannot produce. Bodybuilders use insulin in a totally different way. Some diabetic bodybuilders manipulate their insulin use to use insulin for muscle growth and get good results but changing dosages and times of injection of insulin for diabetics can be dangerous.

Isn't taking insulin dangerous?

ummm YES! Before deciding to take insulin here is what you have to do to be safe.

Insulin safety

1. Do not use slin alone have a training partner or girlfriend who's not using slin hang around with you from the time you take the slin to about 2.5/4 hrs after.

2. Tell you're partner to look for anything out of the norm for your personality and have a list of questions like your ssn or address etc that they can ask you. Don't joke around, and answer them without ****, because if you cant answer or refuse to answer it could be a sign of hypoglycemia(low blood sugar). Symptoms of hypoglycemia include disorientation, headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea.

3. If you cant/wont answer or are feeling the symptoms of hypoglycemia they should be prepared to feed you carbs like pancake syrup, coke, sugary stuff. I bought glucose tablets at walmart. kinda like candy but gets in the blood faster and dissolve quickly. these are for diabetics ask at the pharmacy.

4. Have your partner know that if they suspect low blood sugar and cant convince or force you to consume carbs until your better. CALL 911 and ask for an ambulance and tell the truth to the operator... that they suspect you are in insulin shock and explain when they get there(the ambulance guys not the cops) that you are not diabetic but using insulin for anabolic purposes. Have the type of slin, the dosage and carbs consumed recorded to give the paramedic. They will save your life. Then you refuse transport to the hospital and eat. It might be a good idea to make sure your house is "clean" before every workout just in case the bad thing happens and the cops ask a lot of questions.

5. Why so much preparation for the possible problem?? insulin can kill you in minutes if you go down!!

6. Take the carbs and protein together immediately after injecting the slin(dont take chances trying to time out 15 min after injection). Take the protein with the carbs because the protein is pushed into the muscles with the slin also(creatine too).

7. Before an hour passes you should eat a normal balanced meal(high protein low fat with carbs).

8. Consume another small high protein medium carb low fat meal at 2.5 hours after the injection. Congrats you lived.(keep some gatoraid on hand just to make sure because your not gonna have a lifeline)

9. YAWN... Don't go to sleep within 4/6 hours of using insulin since you can develop hypoglycemia while asleep and not have warning signs.

Ok I'm not scared I still want to use insulin...

Where do i get it?

Humulin R is over the counter (OTC) just about everywhere. Humulog is new and is still a prescription drug is some places. BUT... Insulin is NOT a controlled substance and will not be confiscated by customs or postal inspectors so order it online if you cant get it locally. Its legal.

Where do I keep it? (STORAGE)

The FDA requires that all preparations of insulin contain instructions to keep in a cold place and to avoid freezing. The refrigerator is a good spot. Unrefrigerated insulin can be kept of 28 days as long as it stays in a cool and dark place.

Where/how do I inject insulin?

The best sites for insulin injection are in the subcutaneous tissue of the abdomen(avoid the area close to bellybutton) .Usually, you should not inject within 1 inch of the same site within 1 month. The arms and legs can also be used, but insulin uptake from these sites is less uniform. Insulin should be injected subcutaneously only with a U-100 insulin syringe. "B-D ultra-fine" insulin syringes are good. Insulin syringes are available without a prescription in many states. If you cant purchase the syringes at a pharmacy, you can mail order them. Using a syringe other than a specific insulin syringe is dangerous since it will be difficult to measure out the correct dosage.

How much insulin should I take?

I recommend never using over 10IU. 10IU is enough to make you grow.
In general Dosages used are usually 1 IU per 20 pounds of lean bodyweight. So a 220lb bodybuilder with 9% body-fat would use 10iu of insulin(aprox200lb lean mass/20 = 10iu). But even experienced insulin users shouldn't use max dosage at the beginning of an insulin cycle. First-time users should start at a low dosage and gradually work up. For example, first begin with 2 IU and then increase the dosage by 1 IU every consecutive workout until you reach your calculated dose or determine a maximum personal dose(some people are more sensitive to insulin sides like hypoglycemia). This will allow the athlete to determine a dosage he can safely use. Insulin dosages can vary significantly among athletes and are dependent upon insulin sensitivity and the use of other drugs. Athletes using growth hormone and thyroid might have higher insulin requirements.


When do I take insulin?

It is my opinion that you should only take insulin after a work out, never before or when not working out, because before a work out you could crash and die during the workout and when your not working out it makes you fat. Some people disagree with this. IF you want, get some info from them and try it. But remember I told ya so.

When do i eat after using insulin?

Immediately!!! DO NOT TRY TO TIME YOUR CONSUMPTION OF CARBS!! You should immediately take a carbohydrate AND protein drink after taking you're insulin. I've stated this twice because it is very important. Even experienced insulin users can get a surprise now and then.
Eat a meal at about an hour after using insulin. Consume another small high protein medium carb low fat meal at 2.5 hours after the injection. keep some gatoraid on hand just to make sure. Remember that insulin can still work much later so be careful and eat if you feel hypoglycemia symptoms.


What do I eat after using insulin?

Some people recommend a zero fat intake for 4 hours after taking insulin. I do not disagree with this. But if your bulking you can be a little relaxed on this. But high fat intake after taking insulin can lead to high body fat.
The carb/protein drink taken after the insulin shot should contain AT LEAST 10 grams of carbs and 5 grams of quality protein per IU of insulin injected with little or no fat(creatine taken in this drink is optional but works great). Before an hour passes you should eat a normal balanced meal(high protein low fat with carbs). At 2.5 hours after the injection you should Consume a small meal. keep some gatoraid on hand just to make sure. Remember that insulin can still work much later so be careful and eat if you feel hypoglycemia symptoms. Once again i've stated this twice because it is important.

***Some insulin users recommend far less carbs than I have stated above. This is a personal decision you will have to make since it could be very dangerous...Even deadly! My opinion is to take the carbs and learn to diet after bulking if you gain too much fat.***

How long should/can I take insulin?

Short cycles please because you could have side effects. It is suspected that you could become an insulin dependant diabetic but I have never seen proof, but is it worth the risk? I would only use it a few times a week(maximum 4 on 3 off) for no more than 3/4 weeks.

What should I avoid while using insulin?

Do not use alcohol. It lowers blood sugar, and you may experience dangerously low blood sugar levels.

[Basset]

Thank you for sharing. What is the gatoraid on hand for?

[michaelton]

Originally Posted by Basset

Thank you for sharing. What is the gatoraid on hand for?

Keep that or sugary soda, or OJ, or those little sugary candies you can chew and swallow fast in case you feel the effects of hypoglycemia.

[Basset]

Oh ok. I didn't think of it as high GI. I have those glucose tabs and I got some dextrose from a beer making site.

Thanks for clearing that up in my mind.

Basset

[JBlaze]

First off i'd like to say, i think the dosages recommended in this post are kind of high, but since it's a cut and paste, i will not tamper w/ it. So PLEASE do not think you need to use between 15-45ius daily to see results! I'd say more along the lines of 10-30 max per day, or 5-15iu's per injection.


Insulin: The Most Anabolic Hormone
by Grendel

Look back through picture archives of bodybuilding and you will be struck by a startling fact. In the last half-decade bodybuilders have been getting much larger much quicker. Certain professionals have added twenty pounds to their contest weight in one season, after having seemingly reached a plateau. The bodybuilding audience loves to hear that this weight gain is due to some secret drug or some newly discovered gene therapy. Elaborate theories are developed to explain these rapid weight gains and the professionals themselves are not helpful; they claim that it's the new X-brand supplement that's doing it and leave it at that.

The truth is that bodybuilders have discovered the most anabolic hormone produced by the body, insulin. Additionally, insulin has the benefit of being not only legal and over the counter in most states, but it is very cheap. A bottle costs less then thirty dollars and there is no need to worry about counterfeits. By correctly using insulin, in conjunction with human growth hormone and anabolic steroids, modern professionals have added pounds of mass onto seemingly stagnant physiques.

This chapter will give a brief overview of insulin and the methods by which its anabolic action is exerted. We will outline how to correctly and safely use insulin both to gain size and to prepare for a contest (or simply diet).

Insulin: The Overview

Insulin is a peptide hormone, secreted by the pancreatic islets of Langerhans. Insulin promotes glucose utilization, protein synthesis, and regulates the metabolism of sugar. Insulin travels until it reaches receptor sites on cells. At these sites insulin facilitates the transport of glucose and amino acids across the cell membrane to be used inside the cell for energy and protein synthesis. This is insulin's anabolic effect, not only in super-saturating the cells with nutrients, but also helping to volumize the cell.

Insulin Safety:

There are significant risks that accompany the use of insulin. The greatest risk is an over-dose of insulin, which leads to hypoglycemic shock. This is not an overdose in the typical sense of the word; in this case it means that too much insulin was administered for the amount of glucose in the bloodstream. To this end, it is important to choose the correct type of insulin and to know when it peaks and the effective period of action of the drug in your body. This information is provided later in this chapter.

The symptoms of insulin shock are easy to recognize.
Distress is relatively rapid, usually in a matter of minutes.

Hunger.
Sweating.
Cold, clammy feeling.
Paleness.
Trembling, anxiety.
Rapid heartbeat.
Feeling of weakness or faintness.
Irritability and change in mood or personality.
Loss of consciousness.

Treatment:

Feed the person a source of quickly absorbed sugar. If the person is conscious, table sugar, fruit juice, honey, a non-diet soft drink, or any other available sugar source will do. If the person is unconscious, do not try to force sugar or liquid down his throat. Honey, granulated sugar, or a special capsule (such as D-glucose) containing concentrated sugars, which some diabetics carry, can be carefully placed under the tongue where it is absorbed into the body. However, this may be difficult to do.

There is another rapid form of intervention that anyone using insulin should know about; a glucagon pen. Injectable glucagon is a hormone, normally produced in the pancreas, which has effects opposite to those of insulin. It is commonly used to treat hypoglycemia or low blood sugar. It may also be used to relax parts of the gastrointestinal tract for certain examinations. It is not a controlled substance. In the event of the onset of hypoglycemia, this emergency injection will pull your blood sugar back up. If you are using insulin, you should have one of these pens with you at all times.

Take the person to a hospital emergency room as quickly as possible. Severe insulin reactions can be fatal. Do not be afraid of getting into "trouble", the use of insulin is legal. You will certainly get a lecture about how crazy it is to use insulin, but you will not be arrested or detained in anyway.

It is extremely important to have someone who you can trust monitor you when you are using insulin. They should be aware of the signs of insulin shock as well as the course of action to follow in the event that you do slip into a hypoglycemic state. Some insulin users will go so far as to purchase a medic alert bracelet that indicates them as a diabetic in the even that they pass out in public.

During a bulking phase, when calorie intake is deliberately high, insulin shock is not likely to be a problem assuming that post injection nutrition is precise (as outlined later in the chapter). In the even that you begin to feel any of the above symptoms immediately begin to consume the most simple sugars you can find, particularly look for glucose polymers and dextrose. Avoid fructose, as it is ineffective at raising blood sugar levels rapidly.

In the event that you are using insulin in dieting, do not be afraid to "blow your diet" by eating candy if you feel your blood sugar getting dangerously low. Your diet is not worth your life.

Types of Insulin:

There are three important characteristics that differentiate the available types of modern insulin. To properly use insulin in bodybuilding it is important to know the following characteristics:

Onset:

the time it takes the injected insulin to reach the blood stream and begin to work.

Peak:

the time period in which the insulin is working it's hardest to lower the blood sugar.

Duration:

the length of time the insulin will be working in the bloodstream. It is important to remember that insulin is an indiscriminate storage hormone. It doesn't care if its storing fat or glucose. Therefore fat intake should be as low as possible during the effective period of the insulin in the body. This will help prevent excessive fat gain.

For bodybuilding purposes we will only be concerned with three types of insulin; Humalin "R", Humalin "N" and Humalog are the most useful types of insulin. The other varieties are mixes of the above types in set ratios.
Humalin "N" is the longest acting insulin; it is active in the body for 24 hours.

Additionally, it peaks several times throughout the day. Humalin "N' is useful in the high calorie off-season when there will always be an abundant supply of glucose. However, even the most dedicated bodybuilder who is eating many small meals may run into serious trouble in the insulin peak corresponds to a period of low blood sugar. Also, the long duration of Humalin "N' means that the bodybuilder must adhere to a low fat diet throughout the day, which is incongruously with the eating necessary to achieve brutal size.

Humalin "R" is known as the rapid insulin. The manufacturers claim that this type of insulin is active in the body for up to six hours; in reality it's closer to four and a half hours. The onset time of "R" is roughly thirty minutes and the drug peaks in one and a half to two and a half hours after injection.

Humalog is the fastest acting insulin. It has duration of about 2 hours, peaks in fifteen minutes, and is ideal for bodybuilding purposes because it is out of the body quickly. The speed at which Humalog works is beneficial because it allows us more precise control and lets us know exactly when food needs to be consumed.

Insulin Injection Procedure:

Insulin can be injected intravenously, intramuscularly, or subcutaneously. Injection insulin into the veins is creepy, but safe. However, it is not necessary to do this, as injection insulin into muscle or under the skin is just as effective.

The injection site, exercise, and the accuracy of the dosage measurement, the depth of injection and by environmental temperatures, can affect insulin absorption. To obtain consistency in daily insulin absorption and action, you should vary injection sites within the same anatomical region. The abdomen provides an excellent area for consistent absorption of insulin, whereas the leg and arm areas are often affected more by exercise.

Repeated injection in the same area may cause a delay in absorption whereas massaging the site of injection may lead to an increased rate of absorption. Insulin should be injected at a 90-degree angle using an insulin syringe (25 unit, 30 unit, 50 unit, or 100 unit size) or with an insulin pen. If redness, pain, or lumps are noted at the injection site, this area should be avoided until the problem goes away.

Be sure to follow proper sterilization procedures. Wipe down the injection area with alcohol. The insulin needle is very thin so bleeding should be minimal. However, press a swab of cotton soaked in alcohol over the injection site after you withdraw the needle. This will protect almost entirely against infection.

An increase in blood flow to an injection site will increase the rate that insulin is absorbed. So, exercise will cause insulin to be absorbed more rapidly, because blood flow has increased to the exerted muscle groups. You will need to either inject less insulin or eat more carbohydrates after exercise. Rubbing the injected area increases blood flow, and hence, absorption.

Post Injection Meals and Supplements:

Depending on the onset time of the insulin type you are using you have varying lengths of time in which to ingest the post-insulin meal. Generally your post insulin meals should follow these guidelines. 60-80 grams of a good quality protein powder. Whey protein is ideal. This is taken immediately after the injection. 7 grams of simple carbohydrates (not fructose as it does not raise blood sugar quickly enough) per IU of insulin injected. Every 15-20 minutes after the first shot, take a few glucose tablets. This is will increase the amount of glucose available to your body for storage.

200 mg of chromium picolinate (this is optional).
200 mg of lipoic acid (this is optional).
30 mg vanadyl sulfate (this is optional).
2000 mg of hydroxy citric acid (this is optional).
5-7 grams of creatine monohydrate. This is crucial.
5-7 grams of glutamine powder. This is also crucial.

The total amount of insulin that you will be using daily is roughly 15-45 IUs depending on how many carbohydrates you can eat that day. During dieting periods, the total amount of insulin will be greatly reduced.

Typically, three injections of insulin are used daily. The first is taken immediately upon awaking; this is an appropriate time to use the Humalin "R". The second shot is taken mid-day and Humalog is recommended. The last injection is taken immediately after the workout of the day. If you are doing a double split training program, then take one shot after each workout and adjust your other injection accordingly. Do not take an injection too late at night; you want to be able to stay awake through the entire period of action so you can monitor yourself for signs of low blood sugar.

Anyone who is going to use insulin should take some time to familiarize him or herself with the glycemic index. The glycemic index is a ranking of foods based on how they effect the body's blood sugar levels. There are many resources that provide elaborate listing of many types of foods including fast foods. For our purposes it is merely important to identify the foods with high glycemic index scores to consume with the insulin injection. Below is a list of foods (or sugars) that scored very highly on the glycemic index.

Whole Foods or Candies

Jelly Beans
Dates Sugar types
(in ascending order; Maltose elevates blood sugar the most)
Lactose
Honey
High fructose corn syrup
Glucose
Glucose tablets
Maltodextrin
Maltose

Conclusion

For many, insulin may seem like the perfect bodybuilding drug. It's legal, cheap, effective, and easy to obtain. However, the decision to use insulin is not one that can be made lightly. At worst, the misuse or abuse of anabolic steroids will probably result in no more than elevated liver enzymes and a host of undesirable cosmetic side effects. Improper use of insulin will result in much more serious consequences, including death. Bodybuilders must first ask themselves if they possess the necessary maturity and intelligence to responsibly use this hormone. Look before you leap my friends.

[JBlaze]

Posted by Foxy Sphinx from ana review.




Truth or Dare: A comprehensive look at Insulin use

--------------------------------------------------------------------------------

Here it is, almost everything you've ever wanted to know about Insulin, and then some.


What is Insulin
Insulin is a hormone produced in the pancreas which helps to regulate glucose levels in the body. Medically, it is typically used in the treatment of diabetes. Recently, insulin has become quite popular among bodybuilders due to the anabolic effect it can offer. With well-timed injections, insulin will help to bring glycogen and other nutrients to the muscle.


Types of Insulin

Very Fast acting - The fastest acting insulins are called lispro (Humalog)and insulin aspart (Novolog). They should be injected under the skin within 15 minutes before you eat. You have to remember to eat within 15 minutes after you take a shot. These insulins start working in five to 15 minutes and lower your blood sugar most in 45 to 90 minutes. It finishes working in three to four hours. With regular insulin you have to wait 30 to 45 minutes before eating. Many people like using lispro because it's easier to coordinate eating with this type of insulin.

Fast acting - The fast acting insulin is called regular insulin. It lowers blood sugar most in 2 to 5 hours and finishes its work in 5 to 8 hours.

Intermediate acting - NPH (N) or Lente (L) insulin starts working in one to three hours, lowers your blood sugar most in six to 12 hours and finishes working in 20 to 24 hours.


Using Insulin

What Insulin to use
In America, regular human insulin is available without a prescription by the name of Humulin R by Eli Lilly and Company. It costs about $20 for a 10 ml vial with a strength of 100 IU per ml. Eli Lilly and Company also produces 5 other insulin formulations, but none of these should be used by bodybuilders. Humulin R is the safest because it takes effect quickly and has the shortest duration of activity. The other insulin formulations remain active for a longer period and can put the user in an unexpected state of hypoglycemia.

Where should you inject
Humilin R should be injected subcutaneously only with a U-100 insulin syringe. Insulin syringes are available without a prescription in many states. If the athlete cannot purchase the syringes at a pharmacy, he can mail order them or buy them on the black market. Using a syringe other than a U-100 is dangerous since it will be difficult to measure out the correct dosage. Subcutaneous insulin injections are usually given by pinching a fold of skin in the abdomen area. Insulin injected near the stomach works fastest. Insulin injected into the thigh works slowest and a shot in the arm works at medium speed.

Using safely
Most athletes will bring their insulin with them to the gym. Insulin should be refrigerated, but it is all right to keep it in a gym bag as long as it is kept away from excessive heat. Immediately after a workout, the athlete will inject his dosage of insulin. Within the next fifteen minutes, he should have a carbohydrate drink such as Ultra Fuel by Twinlab. The athlete should consume at least 10 grams of carbohydrates for every 1 IU of insulin injected. Most athletes will also take creatine monohydrate with their carbohydrate drink since the insulin will help to force the creatine into the muscles. An hour or so after injecting insulin, most athletes will eat a meal or consume a protein shake. The carbohydrate drink and meal/protein shake are necessary. Without them, blood sugar levels will drop dangerously low and the athlete will most likely go into a state of hypoglycemia.

Insulin and Bodybuilding
Insulin is used in a wide variety of ways. Most athletes choose to use it immediately after a workout. Dosages used are usually 1 IU per 10-20 pounds of lean bodyweight. First-time users should start at a low dosage and gradually work up. For example, first begin with 2 IU and then increase the dosage by 1 IU every consecutive workout. This will allow the athlete to safely determine a dosage. Insulin dosages can very significantly among athletes and are dependent upon insulin sensitivity and the use of other drugs. Athletes using growth hormone can thyroid will have higher insulin requirements, and therefore, will be able to handle higher dosages. Insulin is used in bodybuilding because it qromotes glycogen synthesis and storage for maximum endurance in ergogenic activity (Your workout). It also helps shuttle the nutrients, glucose and energy into your cells when your muscles are training hard, when it really counts. It is important for bodybuilders to understand that when insulin levels are high your body will store excess glucose as bodyweight. Unfortunately, your body does not care if it is muscle weight or fat weight. It is important to realize the difference in carbohydrates and their use by muscle tissue. Enzymes within muscles readily metabolize starch, which is broken down into usable glucose. The liver has the intermediary enzymes to convert glucose, fructose, galactose, amino acids, and other metabolites for its glycogen stores. Since your muscles have the ability to store 250 to 400 grams of glycogen and your liver only has the ability to store 100 grams of glycogen, it is advisable to keep a high proportion of your carbohydrate calories from complex sources. As mentioned earlier, muscle glycogen is only used by muscle tissue. Since muscle glycogen is similar to an amylopectin as in starch, it is logical to supply your body with complex carbohydrates to replenish muscle glycogen stores.

How to store it
* If you use a whole bottle of insulin within 30 days, keep that bottle of insulin at room temperature. On the label write the date that is 30 days away. That date is when you should throw out the bottle with any insulin left in it.
* If you don't use a whole bottle within thirty days then you should store it in the refrigerator all of the time.
* If insulin gets too hot or too cold, it doesn't work right. So, don't keep insulin in the freezer or in the glove compartment of your car during warm weather.
* Keep at least one extra bottle of insulin around your house. Store extra insulin in the refrigerator.


Future of Insulin delivery

Insulin inhalers
Although daily injections of insulin would still be needed, inhaled insulin is currently in clinical trials and may be headed for a fast track approval by the Food and Drug Administration (FDA). These inhalers are about the size of a flashlight and uses rapid-acting insulin. The sprayed insulin is inhaled into the mouth and coats the mouth, throat and tongue. The insulin passes quickly into the bloodstream.

Insulin Pill
The discovery of a new polymer that may allow development of an effective insulin pill was reported at a recent meeting of the American Chemical Society. When the polymer is used as a pill coating, it allows insulin to get into the bloodstream without being destroyed by the digestive system. So far it has only been tested in animals. Some experts question whether insulin in pill form will prove useful, since dosing is so critical and often variable.


Insulin and Hypoglycemia

What is hypoglycemia
Hypoglycemia occurs when blood glucose levels are too low. It is a common and potentially fatal reaction experienced by insulin users. Before an athlete begins taking insulin, it is critical that he/she understands the warning signs and symptoms of hypoglycemia. Generally, a level below about 60 mg/dl is called low blood sugar.

Symptoms of Hypoglycemia
The following is a list of symptoms which may indicate a mild to moderate hypoglycemia: hunger, drowsiness, blurred vision, depressive mood, dizziness, sweating, palpitation, tremor, restlessness, tingling in the hands, feet, lips, or tongue, lightheadedness, inability to concentrate, headache, sleep disturbances, anxiety, slurred speech, irritability, abnormal behavior, unsteady movement, and personalivy changes. If any of these warning signs should occur, an athlete should immediately consume a food or drink containing sugar such as a candy bar or carbohydrate drink. This will treat a mild to moderate hypoglycemia and prevent a severe state of hypoglycemia. Severe hypoglycemia is a serious condition that may require medical attention. Symptoms include disorientation, seizure, unconsciousness, and death.


Keep it safe everyone, if you use Insulin take it very seriously... its not like any other bodybuilding compound. If you found this helpful, please give er a bump so others may benefit as well.

[motiv8er]

Some very good reads. Thanks Blaze.

[mywetnightmares]

This is from BtPB, I made a few edits so it would be easier to understand a nd I corrected typos where I saw them, but I know I didn't get them all.


INSULIN
Insulin is the most anabolic hormone, yet it is anti-catabolic as well. Since this is a storage hormone, anabolism is initiated by inducing storage intracellularly of glucose, amino acids, and fats, as well as electrolytes. Remember, creatine is an
amino acid structure as are several growth inducing chemicals. As well, there is a great deal of evidence that by creating a state of cellular hydration, supraphysiological insulin induces a secondary anabolism and cellular hypertrophy.

Insulin has anti-catabolic qualities simply because the presence of Insulin in the blood stream at high enough levels prevents catabolic hormones such as cortisol and glucagon from becoming elevated. This obviously creates a state in which amino acids and glucose cannot exit cells.

As noted in the treatment of type II diabetics, insulin receptor-sites can be desensitized from over use of exogenous Insulin. Ever notice how fat diabetic couch potatoes get? This is because the lack of exercise allows muscle cell insulin receptor sites to become insulin resistant and the fat cells become the main point of storage. Which of course sucks! For this reason, (and others) long protocols with exogenous insulin could have greatly reduced long term potential.

There were some supplements employed that enhanced Insulin sensitivity and allowed for lower dosages to be more effective. This in turn helped to prevent Insulin resistance. Alpha Lipoic Acid, Chromium, Corosolic Acid, D-Pinitol, Selenium, 4-Hydroxyisoleucine, L-Phenyl Alanine, and Courdin which is a fraction from bitter melon (Momridica Charantia).

These supplements made a huge difference in results both during and post-insulin use. Frank always included a mixture of 200 mg Alpha Lipoic Acid, 1000 mg L-Phenyl Alanine, and 50 mg of D-Pinitol twice daily with Insulin, and twice daily for 14 days after with 4-hydroxyisoleucine added at a dosage of 200mg 2xd.

Over the years, I have noted many athletes obtained the same results utilizing "up to" half of their normal exogenous Insulin dosages with this supplement schedule. They also stored less fat.

Another addition said to lower fat storage was HCA(Hydroxycitric Acid) which is supposed to decrease conversion of carbohydrates to fat by inhibiting its conversion
enzyme. 1000 mg 2-4 times daily. My personal experience has been that HCA is not effective.

The essential fatty acid supplement CLA was probably the best OTC product for fat synthesis inhibition during exogenous insulin use. (We are currently patenting a
fat that tells the body to not store fat and to burn fat at a higher rate. This is like super CLA x 10)

Misuse of Insulin and the normally required 10 g of carbs or appropriate super substrate per i.u. has been known to lead to coma, beta cell burn out, pancreatic damage, and blindness among other things such as cataracts.

Insulin significantly and quickly reduces blood sugar and can create a state of hypoglycemia. You will need to know that later. (There will be a test) This means insulin is a major storage hormone, right?! So it was absolutely vital for Frank or any of the beasts to protect against Insulin insensitivity. GH release was inhibited by elevated blood sugar by the way. Think about it.

The examples that follow often list Humalog or Humulin-R insulin because they are fast/short acting and easier to control. Going to sleep with supraphysiological insulin levels could have killed. So by utilizing a fast acting Insulin, the system was mostly clear within 1.5-3 or 6-8 hours respectively after injection.

Obviously a meal before sleep was a must. For Frank, or any beast, a single injection of Humulin-R that exceeds 1 i.u. per 10 lbs. of body weight would have significantly increased risks. This was simply because metabolic processes would not
have been able to keep up with necessary glucose supplies in most cases.


THINGS TO THINK ABOUT...

I realize I have pointed this out several times, but Action/Reaction principles applied for greatest growth potential rely on synergy. This meant not only strategic
use of drugs that interacted to induce a more powerful stimuli, but also anticipating and responding to the negative feed-back loops drugs can produce.

In the applications I had utilized with Frank and other beasts, this required atleast a basic understanding of drug Action/Reaction Factors as well as drug interaction. Using Insulin and GH as an example, let's look at some factors taken into consideration.

GH and Insulin Action/Reaction Factors

1. Insulin is hypoglycemic - GH is hyperglycemic.
2. Insulin is fat storing - GH is fat releasing.
3. Insulin promotes cellular uptake of about half of the amino acids needed for repair and growth - GH promotes the uptake of the other half.
4. Insulin increases T-4 conversion to T-3 - GH decreases liver conversion of T-4toT-3.

Specific Intent Considerations

GH use without an androgen or Insulin would have been anti-catabolic yet not as anabolic. GH use alone would not have increased muscle fiber contractile proteins significantly. This is due to GH lacking the ability to induce uptake of "all" essential amino acids and therefore most growth occurs in structural proteins.

Since GH can also decrease T-3 levels, protein synthesis decreases and growth would have occurred due to a stronger alteration in the catabolic side of the Anabolic/Catabolic ratio. We added insulin and growth occurred in both contractile and structural proteins due to greater complete amino acid profile and ratio availability and adequate T-3 levels that allowed elevated protein synthesis. This is
greatly simplified but an adequate explanation of Action/Reaction Synergy.

Another considered and included point of synergy between Insulin and GH was this: Insulin and IGF-1 each potentially stimulate the other's receptor sites when plasma levels are supraphysiological. GH converts to IGF-1 in the liver, and stimulates the release of IGF-1 in muscle cells. Stacking GH and Insulin obviously resulted in a great deal of IGF-1 receptor-site activity for beasts. Interesting huh?

There are several forms and origins of exogenous Insulin used to treat diabetics. The options were numerous but experience had taught me that the fast acting (short acting) insulin's had benefits and a greater control safety (no, Insulin is not "safe" by any means without proper medical guidance) over long acting Insulin. Just as different AAS we had employed had different half and active-lives, so did insulin's. And just like AAS, longer acting Insulin's took a longer period to become active.

The use of insulin with an active period of more than 6-8 hours without stacking it with GH was not the best approach in most situations. First, due to long periods of possible and dangerous hypoglycemic activity, and second due to a decrease in endogenous GH release in the presence of elevated insulin levels, the benefits did not out-weigh the loss. Remember synergy and Action/Reaction?

I have noted that athletes who utilized very-short or short acting insulin were about the same weight as those who favored long-acting insulin's. However, those who used the short-acting insulin carried greater lean mass and less fat in
comparison. But it seemed to be equal regardless of insulin type administered when 1-2iu of GH was layered in 2-5 times daily during insulin protocols.

EXAMPLES OF INSULIN

Very short acting
(Humalog)
Start activity: 10 Minutes
Highest Activity: 1.5 Hours
Ends Activity: 3 Hours
Low Blood Sugar: 2-4 Hours

Short-acting
(Regular/-R)
Start Activity: 20 minutes
Highest Avtivity: 3-4 hours
Ends Activity: 8 hours
Low Blood Sugar: 3-7 hours

Intermediate Acting
(Nor L)
Start Activity: 1.5-2 hours
Highest Activity: 4-1 5 hours
Ends Activity: 22-24 hours
Low Blood Sugar: 6-13 hours

Long-acting
(Ultra Lente)
Start Activity: 4 hours
Highest Activity: 10-24 hours
Ends Activity: 12-28 hours
Low Blood Sugar: 12-28 hours

Combination
(70%N/30% R)
Start Activity: 0-1 hour
Highest Activity: 3-1 3 hours
Ends Activity: 12-20 hours
Low Blood Sugar: 3-12 hours

Combination
(50%N/50% R)
Stat Activity: 0-1 hour
Highest Activity: 3-1 2 hours
Ends Activity: 12-20 hours
Low Blood Sugar: 3-12 hours

• Humalog was administered about 15 minutes before an appropriate meal.
• Regular Type-R was administered 30 minutes before an appropriate meal.

It would seem obvious that when Frank had utilized a protocol that required 30iu of insulin per day with 2iu of GH 3-5xd he could have theoretically administered 30iu of Combination: 70% N/30% R subcutaneously upon waking in the morning (About 10 minutes before a meal), if a meal had been ingested just prior to retiring the night before. But there is a problem with that. Go re-read GH and Insulin Action/Reaction Factors.

This would have been applicable only during a mass phase. This is due to the fact that insulin stops the fat burning effect of GH. So the better choice was GH first and a fast acting Insulin 30-60 minutes later.

NOTE: A fragment of the GH molecule stimulates the B-3 receptors on fat cells. This then triggers lipolysis (fat burning) while simultaneously blocking fat storage.

Some have stated that they believe an elevation in insulin during GH activity would result in a decrease in anabolic value. This is interesting in that both GH and insulin must be present in the liver and available to tissues for the synthesis of IGF-1. As most are aware IGF-1 is by far a superior anabolic on a dose dependent basis and all three are necessary for the natural synergy need for maximum growth.

[PSJ02388]

very useful information...makes me fell more knowlagable fo insulin usage

[adidamps2]

can insulin be used on a keto style diet affectively?
or is it not designed for this kind of use?

[aragorn1500]

I realize this is an old post but I have a question.
I know someone who is an insulin-dependant diabetic, he takes two shots a day, I realize he isn't using it to build muscle, BUT, he doesn't eat after his injections.
Is he able to do this because he is a diabetic?

Thanks.