GH Information Here!

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  1. Quote Originally Posted by Sub7 View Post
    Sorry for this basic question but I still dont understand why GH takes months to kick in. If fat cells have GH receptors and the half life of GH is just hours, why in the world would it take so long to start working?

    it doesnt. its immediate but the effect is so small that it takes a while to see obvious results.


  2. how much is a cycle of hgh?
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  3. Quote Originally Posted by Brolic View Post
    how much is a cycle of hgh?
    depends on your source and how much you plan to use. Price will be between $2-$5 per IU depending on source and quantity you purchase(bulk buying gets lower prices with many sources). you will want 4IUs/day 5 on 2off so 20IUs/wk. then depends how long you run the cycle for as people do anywhere from 1 month to never coming off. Id recommend at least 3-4 months to see good results so you will need around
    240-320IUs which will cost you around $480 upwards.

    again this is very rough and you should seek out some sources to see what you can obtain.
  4. SQ vs IM GH administration: Study


    Just some food for thought here regaring IM vs. SQ GH injections:

    CLINICAL STUDY

    Pharmacokinetics and pharmacodynamics of GH: dependence on route and dosage of administration

    Full Text Source: Pharmacokinetics and pharmacodynamics of GH: dependence on route and dosage of administration -- Keller et al. 156 (6): 647 -- European Journal of Endocrinology

    European Journal of Endocrinology, Vol 156, Issue 6, 647-653
    Copyright © 2007 by European Society of Endocrinology


    Objective: Pharmacokinetic and pharmacodynamic data after recombinant human GH (rhGH) administration in adults are scarce, but necessary to optimize replacement therapy and to detect doping. We examined pharmacokinetics, pharmacodynamics, and 20 kDa GH after injection of rhGH at different doses and routes of administration.

    Design: Open-label crossover study with single boluses of rhGH.

    Methods: Healthy trained subjects (10 males, 10 females) received bolus injections of rhGH on three occasions: 0.033 mg/kg s.c., 0.083 mg/kg s.c., and 0.033 mg/kg i.m. Concentrations of 22 and 20 kDa GH, IGF-I, and IGF-binding proteins (IGFBP)-3 were measured repeatedly before and up to 36 h after injection.

    Results: Serum GH maximal concentration (Cmax) and area under the time-concentration curve (AUC) were higher after i.m. than s.c. administration of 0.033 mg/kg (Cmax 35.5 and 12.0 µ g/l; AUC 196.2 and 123.8). Cmax and AUC were higher in males than in females (P < 0.01) and pharmacodynamic changes were more pronounced. IGFBP-3 concentrations showed no dose dependency. In response to rhGH administration, 20 kDa GH decreased in females and remained suppressed for 14–18 h (low dose) and 30 h (high dose). In males, 20 kDa GH was undetectable at baseline and throughout the study.

    Conclusions: After rhGH administration, pharmacokinetic parameters are mainly influenced by route of administration, whereas pharmacodynamic variables and 20 kDa GH concentrations are determined mainly by gender. These differences need to be considered for therapeutic use and for detection of rhGH doping.



    Male/Female Data

    Discussion

    The present data demonstrate that gender, dose and route of administration specifically alter bioavailability of and response to exogenous rhGH in healthy young adults. Pharmacokinetic variables were mainly influenced by the route of administration, whereas pharmacodynamic responses were primarily determined by sex. Furthermore, suppression of the 20 kDa GH isoform after injection of rhGH could be demonstrated only in women; 20 kDa GH levels in males were already low at baseline.

    We assessed trained, but not elite level, subjects and highly trained individuals may respond differently to rhGH administration. With no exogenous rhGH, reduced serum IGF-I and IGFBP-3 concentrations have been reported during intense training (18, 19). The dose of rhGH used in this study was supraphysiological, because it can be assumed that illegal use by athletes will be at high doses (20). Physiological rhGH replacement in GH-deficient adults requires approximately one-third to one-fifth of the dose used in this study (21). Despite the high rhGH doses, we observed few of the side effects previously described in adults with GH deficiency (22, 23). However, a high frequency of diarrhea was seen, particularly after administration of the high rhGH dose. We found no explanation in regard to diet or gastrointestinal infections, and speculate that fluid regulation disturbances induced by the high dose could have caused the diarrhea (24).

    Cmax and AUC were higher after i.m. than s.c. injection of the identical dose, in accordance with previous reports (25) indicating that serum GH after i.m. injection shows a higher amplitude and shorter duration compared with s.c. injection. Significant differences between males and females were found for GH Cmax and AUC after i.m., but not s.c. injection. Although one could have expected a higher t1/2z after s.c. administration in women, due to the higher s.c. fat (26), t1/2z was not affected by gender, perhaps because the women in the study were trained and lean.

    The increase in IGF-I was positively correlated to baseline concentration, and was not affected by route of administration. Compared to IGFBP-3, the increase in serum IGF-I was faster and more pronounced, consistent with previous publications indicating that the ratio of IGF-I/IGFBP-3 increases immediately after rhGH injection (27). The increase in IGFBP-3 was delayed, not clearly dose dependent and did not return to baseline during the observation period, confirming that IGF-I is a more sensitive marker of GH action in trained adults than IGFBP-3.

    The increase in IGF-I, but not the increase in IGFBP-3, shows a marked sexual dimorphism. Integrated IGF-I release after rhGH injection was significantly higher in males than females, whereas Tmax and Cmax did not differ between sexes. IGF-I and IGFBP3 response is higher in males at low dose. However, it might be the case that the high dose of rhGH being a stronger stimulus also evokes a higher response in females. The difference between sexes is of course most likely due to the influence of estrogens, as all females were on oral contraceptives. No clear difference was seen in IGF-I response but the study was not specifically designed to investigate the impact of estrogens. It has been proposed that use of oral estrogens interferes with hepatic IGF-I production, but women not using estrogen supplementation also exhibit a lower IGF-I response than males (1). Studies in animals indicate that complex mechanisms, including modification of hepatic GH receptor expression, lead to the sexual dimorphism in the somatotropic axis (28). In contrast to serum GH concentrations, IGF-I and IGFBP-3 concentrations did not return to pre-treatment levels within the observation period, supporting the idea of use of these markers to detect doping with rhGH (13, 27, 29).

    The existing studies on the relationship between 22 kDa and 20 kDa isoforms suggest that the secretion is a part of constant percentage of total GH. Therefore, the lower 20 kDa level and the long-term suppression in males seem to be a consequence of the lower total GH concentration. The 20 kDa GH isoform was also suppressed in females after administration of rhGH, consistent with a negative feedback of exogenous rhGH on pituitary GH secretion; the duration of suppression was dose dependent and re-occurrence of 20 kDa in the circulation was seen 26–28 h after low-dose rhGH and 34 h after high dose rhGH. The prolonged changes provide further evidence that the GH isoform pattern can be used to detect the administration of rhGH in females. With the assay method used in this study, 20 kDa GH levels in males were almost undetectable, making it impossible to demonstrate further suppression. Thus, more sensitive assays to quantify the amount of 20 kDa GH are necessary.

    In summary, our data show that in healthy trained adults, responsiveness to rhGH administration is regulated by a variety of factors. Pharmacokinetic parameters are mainly influenced by the route of administration, with higher GH Cmax and AUC after i.m. injection, while pharmacodynamic parameters are mainly determined by gender. These differences need to be considered when decisions are made regarding therapeutic dosing with rhGH. Changes in the molecular isoforms in circulation after injection of rhGH show that in females, measurement of 20 kDa GH could be a useful parameter to detect rhGH doping in athletes.

    References

    1. Burman P, Johansson AG, Siegbahn A, Vessby B & Karlsson FA. Growth hormone (GH)-deficient men are more responsive to GH replacement than women. Journal of Clinical Endocrinology and Metabolism 1997 82 550–555.[Abstract/Free Full Text]

    2. Hoffman AR, Kuntze JE, Baptista J, Baum HB, Baumann GP, Biller BM, Clark RV, Cook D, Inzucchi SE, Kleinberg D, Klibanski A, Phillips LS, Ridgway EC, Robbins RJ, Schlechte J, Sharma M, Thorner MO & Vance ML. Growth hormone (GH) replacement therapy in adult-onset GH deficiency: effects on body composition in men and women in a double-blind, randomized, placebo-controlled trial. Journal of Clinical Endocrinology and Metabolism 2004 89 2048–2056.[Abstract/Free Full Text]

    3. Attanasio AF, Bates PC, Ho KK, Webb SM, Ross RJ, Strasburger CJ, Bouillon R, Crowe B, Selander K, Valle D, Lamberts SW & Hypoptituitary Control and Complications Study International Advisory Board . Human growth hormone replacement in adult hypopituitary patients: long-term effects on body composition and lipid status – 3-year results from the HypoCCS database. Journal of Clinical Endocrinology and Metabolism 2002 87 1600–1606.[Abstract/Free Full Text]

    4. Ho KK & Weissberger AJ. Impact of short-term estrogen administration on growth hormone secretion and action: distinct route-dependent effects on connective and bone tissue metabolism. Journal of Bone and Mineral Research 1992 7 821–827.[ISI][Medline]

    5. Cook DM. Growth hormone and estrogen: a clinician’s approach. Journal of Pediatric Endocrinology and Metabolism 2002; 17: (Suppl 4) 1273–1276.

    6. Langendonk JG, Meinders AE, Burggraaf J, Frolich M, Roelen CA, Schoemaker RC, Cohen AF & Pijl H. Influence of obesity and body fat distribution on growth hormone kinetics in humans. American Journal of Physiology 1999 277 E824–E829.[ISI][Medline]

    7. Hansen TK, Gravjolt CH, Orskov H, Rasmussen MH, Christiansen JS & Jorgensen JO. Dose dependency of the pharmacokinetics and acute lipolytic action of growth hormone. Journal of Clinical Endocrinology and Metabolism 2002 87 4691–4698.[Abstract/Free Full Text]

    8. Jorgensen JO, Moller J, Moller N, Lauritzen T & Christiansen JS. Pharmacological aspects of growth hormone replacement therapy: route, frequency and timing of administration. Hormone Research 1990; 3: (Suppl 4) 77–82.

    9. Russo L & Moore WV. A comparison of subcutaneous and intramuscularly administration of human growth hormone in the therapy of growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism 1982 55 1003–1006.[Abstract]

    10. Kearns GL, Kemp SF & Frindik JP. Single and multiple dose pharmacokinetics of methionyl growth hormone in children with idiopathic growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism 1991 72 1148–1156.[Abstract]

    11. Bidlingmaier M, Kim J, Savoy C, Kim MJ, Ebrecht N, de la Motte S & Strasburger CJ. Comparative pharmacokinetics and pharmacodynamics of a new sustained-release growth hormone (GH), LB03002, versus daily GH in adults with GH deficiency. Journal of Clinical Endocrinology and Metabolism 2006 91 2926–2930.[Abstract/Free Full Text]

    12. Wu Z, Bidlingmaier M, Dall R & Strasburger CJ. Detection of doping with human growth hormone. Lancet 1999 353 895.[CrossRef][ISI][Medline]

    13. Bidlingmaier M, Wu Z & Strasburger CJ. Doping with growth hormone. Journal of Pediatric Endocrinology and Metabolism 2001; 14: (Suppl 4) 1077–1083.

    14. Boguszewski CL, Hynsjo L, Johannsson G, Bengtsson BA & Carlsson LM. 22-kDa growth hormone exclusion assay: a new approach to measurement of non-22-kDa growth hormone isoforms in human blood. European Journal of Endocrinology 1996 135 573–582.[Abstract]

    15. Wallace JD, Cuneo RC, Bidlingmaier M, Lundberg PA, Carlson L, Boguszewski CL, Hay J, Borooujerdi M, Cittadini A, Dall R, Rosen T & Strasburger CJ. Changes in non-22-kilodalton (kDa) isoforms of growth hormone (GH) after administration of 22-kDa recombinant human GH in trained adult males. Journal of Clinical Endocrinology and Metabolism 2001 86 1731–1737.[Abstract/Free Full Text]

    16. Blum WF, Ranke MB, Kietzmann K, Gauggel E, Zeisel HJ & Bierich JR. A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: its use for diagnosis of GH deficiency. Journal of Clinical Endocrinology and Metabolism 1990 70 1292–1298.[Abstract]

    17. Straume M, Veldhuis JD & Johnson ML. Model-independent quantification of measurement error: empirical estimation of discrete variance function profiles based on standard curves. Methods in Enzymology 1994 240 121–150.[CrossRef][ISI][Medline]

    18. Jahreis G, Kauf E, Frohner G & Schmidt HE. Influence of intensive exercise on insulin-like growth factor l, thyroid and steroid hormones in female gymnasts. Growth Regulation 1991 1 95–99.[ISI][Medline]

    19. Tigranian RA, Kalita NF & Davydova NA. Observations on the Soviet/Canadian transpolar ski trek: status of selected hormones and biologically active compounds. Medicine and Science in Sports and Exercise 1992 33 106–138.

    20. Ehrnborg C, Bengtson C & Rosen T. Growth hormone abuse. Baillieres Best Practice and Research. Clinical Endocrinology and Metabolism 2000 14 71–77.

    21. Cuneo RC, Judd S, Wallace JD, Perry-Keene D, Burger H, Lim-Tio S, Strauss B, Stockigt J, Topliss D, Alford F, Hew L, Bode H, Conway A, Handelsman D, Dunn S, Boyages S, Cheung NW & Hurley D. The Australian Multicenter Trial of Growth Hormone (GH) treatment in GH-deficient adults. Journal of Clinical Endocrinology and Metabolism 1998 83 107–116.[Abstract/Free Full Text]

    22. Growth Hormone Research Society. Invited report of a workshop: consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency. Journal of Clinical Endocrinology and Metabolism 1998 83 379–381.[Abstract/Free Full Text]

    23. Root AW, Kemp SF, Rundle AC, Dana K & Attie KM. Effect of long-term recombinant growth hormone therapy in children and adults – the National Cooperative Growth Study, USA, 1985–1994. Journal of Pediatric Endocrinology and Metabolism: 1998 11 403–412.

    24. Hansen TK, Møller J, Thomsen K, Frandsen K, Dall R, Jørgensen JO & Christiansen JS. Effects of growth hormone on renal tubular handling of sodium in healthy humans. American Journal of Physiology. Endocrinology and Metabolism 2001 281 E1326–E1332.[Abstract/Free Full Text]

    25. Laursen T. Clinical pharmacological aspects of growth hormone administration. Growth Hormone and IGF Research 2004 14 16–44.

    26. Vahl N, Moller N, Lauritzen T, Christiansen JS & Jorgensen JO. Metabolic effects and pharmacokinetics of a growth hormone pulse in healthy adults: relation to age, sex, and body composition. Journal of Clinical Endocrinology and Metabolism 1997 82 3612–3618.[Abstract/Free Full Text]

    27. Wallace JD, Ross C, Baxter R, Orskov O, Keay N, Dall R, Rosen T, Jorgensen JO, Cittadini A, Longobardi S, Sacca L, Christiansen JS, Bengtsson B & Sönksen PH. Responses of the growth hormone (GH) and insulin-like growth factor axis to exercise, GH administration and GH withdrawal in trained adult males: a potential test for GH abuse in sport. Journal of Clinical Endocrinology and Metabolism 1999 84 3591–3598.[Abstract/Free Full Text]

    28. Giustina A & Veldhius JD. Pathophysiology of the neuroregulation of GH secretion in experimental animals and the human. Endocrine Reviews 1998 19 717–797.[Abstract/Free Full Text]

    29. Longobardi S, Keay N, Ehrnborg C, Cittadini A, Rosén A, Dall A, Boroujerdi MA, Bassett EE, Healy ME, Pentecost C, Wallace JD, Powrie J, Jørgensen JO & Sacca JA. Growth hormone (GH) effects on bone and collagen turnover in healthy adults and its potential as a marker of GH abuse in sports: A double blind, placebo-controlled study. The GH-2000 study Group. Journal of Clinical Endocrinology and Metabolism 2000 85 1505–1512.[Abstract/Free Full Text]
    Attached Images Attached Images  

  5. should a 18 or 19 year old consider growth hormones and IGF instead of steroids?
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  6. Quote Originally Posted by Joey0808 View Post
    should a 18 or 19 year old consider growth hormones and IGF instead of steroids?
    Maybe the IGF but you won't see GH doing too much good for an 18 or 19 year old. The older ya get the better results you get. In all reality I guess you could but like I said you won't get as much from it until you hit your 30's.

  7. Quote Originally Posted by kbtoy31 View Post
    Maybe the IGF but you won't see GH doing too much good for an 18 or 19 year old. The older ya get the better results you get. In all reality I guess you could but like I said you won't get as much from it until you hit your 30's.
    yea i was curious cuz noone wants us to use PH's
    so i was curious about this i wasnt sure if maybe since we were young it would help give us more of a boost than an older using it.
    like go beyondd our peak

  8. Quote Originally Posted by Joey0808 View Post
    should a 18 or 19 year old consider growth hormones and IGF instead of steroids?
    ...

    I do not recomend use but i agree to a point on the above. I think GH is more effective than IGF-1 no matter who you are. its all about dose, food and routine. I think IGF is good for long long runs. I think GH would "show" sooner. Now i say i think because my testing for those 2 wont begin until summer. I hope to report back good infor though.

  9. Hi mate

    Thanks for the info, 2 question's, i have just got the Serono, Saizen Gh, how much is in that bottle when mixed up, also i am using a 100 cc insluin gauge, what is the best dosage for a new guy on gh??

    I just cant work out how much i should be taking, ie the whole bottle everyday or part of it??

    Best Regards

    D

  10. I am 5'3" 144lbs at about 13 to 14% bf right now. Would taking 2iu per day for 60 days/ standalone do anything? I don't want to use too much with it because of previous issues with gyno. I had surgery and had it removed, but the Dr said he left a little bit of each gland so my nipples wouldn't fall off. Anyway, I have a bottle of Havoc, which is supposed to be very mild. Would that be worth using while on GH? Thanks in advance.

  11. Do i still need to take T3 even if my GH dosage will be 6iu/day along with insulin ?
    Does these 6iu of GH still lowers endogenous thyroid hormone in the body ?
    Is there any scale on the dosage of GH which requires T3 intake ? Maybe over 8 - 10iu ?
    Thanks for any advice.

  12. Quote Originally Posted by ray357 View Post
    I am 5'3" 144lbs at about 13 to 14% bf right now. Would taking 2iu per day for 60 days/ standalone do anything? I don't want to use too much with it because of previous issues with gyno. I had surgery and had it removed, but the Dr said he left a little bit of each gland so my nipples wouldn't fall off. Anyway, I have a bottle of Havoc, which is supposed to be very mild. Would that be worth using while on GH? Thanks in advance.
    Bumping this, would like to hear more about running havoc with ugh. I was considering this when I found this post

  13. Quote Originally Posted by sw bill View Post
    Bumping this, would like to hear more about running havoc with ugh. I was considering this when I found this post
    "hgh" stupid Iphone and there damn autofill

  14. Yes definitely! You still have high test levels and you aren't finished growing. You can really benefit. I started at 40 and got gains in size, decrease in body fat, more energy, better mood and yes after 2 years people think I've been juicing when they see me. It is slow, but steady.

  15. There are many different online sources that claim to sell HGH, if permitted, can anyone tell me which ones are legit?

  16. Quote Originally Posted by jmciii View Post
    Yes definitely! You still have high test levels and you aren't finished growing. You can really benefit. I started at 40 and got gains in size, decrease in body fat, more energy, better mood and yes after 2 years people think I've been juicing when they see me. It is slow, but steady.
    I am 40 and considering IP @ 5iu per day 5 on 2 off. Should I do this alone? Or add maybe tren extreme and ah89, or add test prop, winny?
    Im looking to drop fat and cut up. Any thoughts would be appretiated.

  17. Quote Originally Posted by Reginald View Post
    Okay,okay, I 'll use gHRP6 (let's forget insulin).........
    the point is : if ghrp6 will cause at me an hypoglicemic shock (a mega-drop in sugar blood of mine) ,it'll sufficient to eat sugar (also in sublingual way) and sweet stuff,or I'll need to injection a sugar/water mix in my vein in order to save my life??
    ..help me please,I've never use ghrps before...it's my first time,so,I 'm afraid of its power and hypoglicemia abd hunger it can cause....
    ...however,after a ghrp6 , may I eat all what I want ,or there's the possibility I get an iperglicemic shock or others diseases(if I 'll eat too much?). I remember,someone has told me to y should eat only protein,cause if u eat compose carbs ,u can increase too much your fat and weight................but if ghrp6 will cause an hypoglicemic drow in/shock,so u should eat also carbs (yes simple carbs as sugar,but even compose carbs,i think,doesn't it?)
    GHRP-6 is not insulin you eat whatever you want it doesnt make your blood glucose levels drop that much.

  18. hey i have molluscum do u think that taking ghrp 6 would make this worse??

  19. Quote Originally Posted by Reginald View Post
    sorry,but ,supposing someone(me) use only some hgh cycles without use nothing else and get a hgh deficiency which the time only doesn't restore/heal.....which do u suggest me to use between GHRP6 and Insulin to restore my own hgh pituitary right secretion and why?


    o
    Can you comment on what dose you were on that caused an hgh deficiency? Also, how long were you off before you decided that time will not restore this deficiency that you have?

  20. im very interested in gh to see how its effects are different than growth factors. thanks for posting this educational info
    growth factors and peptides can be used to enhance any cells in the body.

  21. I'm Sorry If This Is A Stupid Question Or Has Already Been Addressed I Missed It. There Is A Stack Available With AD3 Pct And Mass Hgh. Is This A Good Stand Alone Stack? The Pct Threw Me Off.

  22. Sizen 8.8 26 iu i dont have the box with me now how mach in the insoulin siring to be 1 iu

  23. Anyone can anser i have my kid 6 vials 8.8mg sazen and 10ml sodium chlor water for inj 0.09 how long is it ok to keep it in then fringe i use 2iu/day so 1 vial lasts around 13 days is it ok

  24. Here is a question...

    If I was interested on running a cycle based on HGH, what else would I need?
    Do I need to supplement with peptides to control hypoglycemia caused by the HGH itself?
    Would my HGH need modification if I decide to run a regular Testosterone cycle?
    "As above, so below; as below, so above."
    Yulee, Florida - Oh, Well... not much to do here - Hit the gym and gear up!
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