Originally Posted by
rexanator info i found
PEG MGF vs MGF
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Here it is plain and simple for you. Without any complex peptide understanding required other than the fact that PEGylation increases the stability, and lifetime of the peptide.
MGF is responsible for increasing muscle stem cell count through a process called proliferation.
As you see the effect going left to right here is exponential. The more stem cells you have the more that can be stimulated and replicated. In order to singal this replication there has to be sufficient saturation of cell receptors. Because attachment to a receptor is by simple probability, the more peptide and the more time the more probable a cell will reach saturation and begin to replicate.
IF regular MGF has a shorter life span, it has a significantly smaller chance at saturating cells. It is not stable in the blood so its only real chance to bind is right at injection. If you calculate probability of binding via (time x concentration) and then PEG last appx 300 times longer, the probability of MGF having a significant effect is about 300 times at the same dosage. In other words you would need 300 times the regular MGF to bind to as many receptors as the PEGylated version. And even at that case the loss of peptide to the blood so fast would still limit the effects of MGF.
Now you must also consider the cumulative effects of having longer term MGF action. AS you saw in the image, the number of receptors will increase, this increase the probability further for the PEG version so now every time you undergo muscle stem cell replication within the 4-8 days the PEG version is active you increase the probability proportional to the increase in cell number.
So without knowing anything more than multiplication and the law of probability one can see that PEG MGF is significantly more effective.