[radaruckus]

I like the AGE reducing properties of Resveratrol. The life extension crowd should love this as will I

[Royd The Noyd]

Originally Posted by LakeMountD

This is the most debated subject right now. Resveratrol alone is a phytoestrogen. Depending on the uM concentrations in plasma and depending on which cell types we are referring to it can be estrogenic or anti-estrogenic. In fact in some cell types it is considered a superagonist, where it binds much much stronger than estradiol, in other tissues its affinity for the estrogen receptor is equal to that of estradiol, and again in others it has antagonistic effects. With that being said there isn't really any studies that show whether or not this has any effect on the HPTA. I can't really figure out why people are using it for this purpose anyways considering there are such better options out there. It is like trying to use tylenol for controlling pain while having a tooth removed instead of novocaine (extreme example).

Not to mention the fact there are studies that show that it increases progesterone levels significantly in vitro. I am the first to say that in vitro isn't a good determining factor, but it is a start and it still shows that it has these properties.

I believe there is also a study showing a 600% increase in prolactin. However it was done on rats with doses that are realistically not attainable in humans if I remember correctly. Definitely different positives/sides at different doses.

[bassgod272]

Originally Posted by LakeMountD

This is the most debated subject right now. Resveratrol alone is a phytoestrogen. Depending on the uM concentrations in plasma and depending on which cell types we are referring to it can be estrogenic or anti-estrogenic. In fact in some cell types it is considered a superagonist, where it binds much much stronger than estradiol, in other tissues its affinity for the estrogen receptor is equal to that of estradiol, and again in others it has antagonistic effects. With that being said there isn't really any studies that show whether or not this has any effect on the HPTA. I can't really figure out why people are using it for this purpose anyways considering there are such better options out there. It is like trying to use tylenol for controlling pain while having a tooth removed instead of novocaine (extreme example).

Not to mention the fact there are studies that show that it increases progesterone levels significantly in vitro. I am the first to say that in vitro isn't a good determining factor, but it is a start and it still shows that it has these properties.

i have only used it once and that was in POST cycle support. i used it as my "PCT" for an epistane 8 week pulse. i took that with Drive and had no issues. i did not get bloodwork, so just going by how i felt doesn't prove anything at all. i didn't get gyno though! i felt good the entire time also. i agree 100% that there are much better options available for the PCT time frame. thanks a lot for the solid info, reps.

[saludable24]

Originally Posted by LakeMountD

This is the most debated subject right now. Resveratrol alone is a phytoestrogen. Depending on the uM concentrations in plasma and depending on which cell types we are referring to it can be estrogenic or anti-estrogenic. In fact in some cell types it is considered a superagonist, where it binds much much stronger than estradiol, in other tissues its affinity for the estrogen receptor is equal to that of estradiol, and again in others it has antagonistic effects. With that being said there isn't really any studies that show whether or not this has any effect on the HPTA. I can't really figure out why people are using it for this purpose anyways considering there are such better options out there. It is like trying to use tylenol for controlling pain while having a tooth removed instead of novocaine (extreme example).

Not to mention the fact there are studies that show that it increases progesterone levels significantly in vitro. I am the first to say that in vitro isn't a good determining factor, but it is a start and it still shows that it has these properties.

As I understand it, Res is used in PCT not for stimulating the HTPA, but to prevent Gyno as studies suggest it inhibits Breast Tissue stimulation by estrogen (a factor in breast cancer) by binding to receptor sites in the area without activating them. Although, some rat or mouse studies showed increases in sperm count with the use of RES suggesting that it does perhaps do something to the HPTA.

I too keep reading that it is a phyto estrogen ect, so I'm just not sure about it's real world applications or side effects thereof when it comes to PCT, or anything else beyond Anti-Ox properties for that matter.

[EasyEJL]

Originally Posted by saludable24

I too keep reading that it is a phyto estrogen ect, so I'm just not sure about it's real world applications or side effects thereof when it comes to PCT, or anything else beyond Anti-Ox properties for that matter.

well the fact that it is a phyto estrogen is the reason it has serm like capabilities. serm is "selective estrogen receptor modulator" and like you said it tends to bind with the receptors in breast tissue, which means estradiol can't, so it reduces chance of gyno (as a phytoestrogen its far weaker than estradiol is).

[LakeMountD]

Originally Posted by EasyEJL

as a phytoestrogen its far weaker than estradiol is).

This is actually incorrect as stated. As I have mentioned before, it depends on the cell type. In some cell types, such as MCF-7, resveratrol functioned as a superagonist, meaning it was far stronger than estradiol in promoting an estrogen response. MCF-7 is the human breast adenocarcinoma cell line. Resveratrol also increased the expression of native estrogen-regulated genes, and it stimulated the proliferation of estrogen-dependent
T47D breast cancer cells, so saying that it rids the body of breast cancer is also false given some studies that are out there. Bottom line is there isn't much research on resveratrol and its effects on androgens in males and females. This is why I think it is stupid to use it in PCT. Everyone wants the newest thing, but frankly there are a lot better choices out there for controlling estrogen levels and blocking estrogen receptors than resveratrol trust me. I will note, however, that some studies stated the opposite in the above cell lines, but then it comes down to who you want to believe?

The biggest thing here is SIRT1 activation. We all want to live longer and that is the most promising area of research right now. Quercetin and these other ingredients can actually inhibit activation, so using it to prevent glucorinidation isn't going to do you a lot of good.

[EasyEJL]

yah, there really needs to be more studies, and in actual humans in vivo.

[LakeMountD]

Originally Posted by EasyEJL

yah, there really needs to be more studies, and in actual humans in vivo.

Problem is, it is not profitable yet. Big pharma who has the money to conduct these studies won't do so until they see a reason to do so and rightfully so. The rest of the studies are not by any means standardized and I am sure there is a large error base out there by research groups using poor scientific method.

[gogo]

Originally Posted by LakeMountD

This is actually incorrect as stated. As I have mentioned before, it depends on the cell type. In some cell types, such as MCF-7, resveratrol functioned as a superagonist, meaning it was far stronger than estradiol in promoting an estrogen response. MCF-7 is the human breast adenocarcinoma cell line. Resveratrol also increased the expression of native estrogen-regulated genes, and it stimulated the proliferation of estrogen-dependent
T47D breast cancer cells, so saying that it rids the body of breast cancer is also false given some studies that are out there. Bottom line is there isn't much research on resveratrol and its effects on androgens in males and females. This is why I think it is stupid to use it in PCT. Everyone wants the newest thing, but frankly there are a lot better choices out there for controlling estrogen levels and blocking estrogen receptors than resveratrol trust me. I will note, however, that some studies stated the opposite in the above cell lines, but then it comes down to who you want to believe?

The biggest thing here is SIRT1 activation. We all want to live longer and that is the most promising area of research right now. Quercetin and these other ingredients can actually inhibit activation, so using it to prevent glucorinidation isn't going to do you a lot of good.

Any better options that are legal without a script and easily obtainable?

[BLACK747]

sounds good lake really looking forward to this

[bassgod272]

Originally Posted by gogo

Any better options that are legal without a script and easily obtainable?

yep.

[LakeMountD]

Originally Posted by gogo

Any better options that are legal without a script and easily obtainable?

Honestly I rather just go low dose AI for that if you are looking to control estrogen or reduce a lump. It may not be as effective as toremifene and such but it would work. You would need to continually take it.

For gyno, look over the net for transdermal formulas, there are some that I know have worked well for people. As for PCT I think people are confusing the fact that not all SERM's will restore HPTA in PCT. Some do more than others and the amount of Res you would be getting I seriously doubt would be enough to have any effect.

[LMR]

That's one thing I like about this product is the anti-oxidants that clean out free radicals from causing aging effects. Another product to add to my multi vitamin in the morning.