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Quick X-Lean Question

jasonschaffin

Well-known member
What are the main differences b/w 7-a-OH-DHEA and 7-b-OH-DHEA? The first 7-OH product I noticed used the alpha while you guys went w/the beta. Is there a big difference? (I know the structural difference, just wondering about the effects)
 
in for a reply

Interested in the choice of compound too.

Reduce XT (SNS) and Lean Xtreme (DS) both contained hydroxy-DHEA in a proprietary alpha+beta blend.
 
answers?

jasonschaffin said:
What are the main differences b/w 7-a-OH-DHEA and 7-b-OH-DHEA? The first 7-OH product I noticed used the alpha while you guys went w/the beta. Is there a big difference? (I know the structural difference, just wondering about the effects)
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^^^^^

Bump. IBE reps, anything? Just curious about the choice of isomers.
 
And another bump. DS told me they had a typo originally and use a blend of the isomers, not just the alpha. Is yours really just the beta isomer?
 
DR.D said:
How is it you understand that?
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I recall someone from DS saying it doesn't compete for the enzyme that converts cortisone to cortisol like the alpha does. Which is strange now that I think about it since you used to work for them. Will do some more searching.
 
fitnecise said:
I recall someone from DS saying it doesn't compete for the enzyme that converts cortisone to cortisol like the alpha does. Which is strange now that I think about it since you used to work for them. Will do some more searching.
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Exactly. ;) (but I actually worked with them, not for them)
 
7Beta-OH-DHEA counteracts dexamethasone induced suppression of primary immune response in murine spleenocytes.
Sterzl I, Hampl R, Sterzl J, Votruba J, Stárka L.

Institute of Endocrinology, Praha, Czech Republic.

The effect of dexamethasone and of three potential antiglucocorticoids, namely dehydroepiandrosterone (DHEA) and its 7alpha-and 7beta-hydroxylated metabolites, on primary immune response has been studied by measuring the number of plaque forming cells (NPFC) and their viability in a cell culture of murine spleenocytes. As expected, dexamethasone suppressed considerably the NPFC as well as their viability. Surprisingly, DHEA as well as its 7alpha-hydroxylated metabolite decreased significantly the NPFC, while the effect of 7beta-hydroxy-DHEA was different: at low doses it decreased the NPFC, but this effect was less pronounced at higher concentrations. In addition, 7beta-hydroxy-DHEA was able to counteract the effect of dexamethasone on the NPFC. None of the natural steroids affected the cell viability.

PMID: 10659701 [PubMed - indexed for MEDLINE]
 
also looks like 7-alpha, 7-oxo, and 7-beta are very readily interchangeable so you should still get the cortisol reducing effects of 7-alpha and 7-oxo
 
lionelxxl said:
would you mind elaborating?

Not sure if the beta isomer is cheaper..? Or will the addition of both isomers jack up the price?
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The alpha is possibly more androgenic, thus suppressive. Still, that is likely trivial I must admit, unless you're taking relatively large doses. Plus, the alpha has no solid, pertinent advantages over the beta and it also lacks some of the positive properties of the beta. There is more data to support the beta too.
 
chuck89gt5.0 said:
What about x-lean compared to 11-oxo? Because 11oxo is supposed to reduce coritisol levels too? Any comparison?
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11-oxo has the additional property of being fairly androgenic, mildly anti-estrogenic, and even anabolic at higher doses (approaching 500mg/day and greater.) These additional properties can be a plus or a minus, depending on the application.
 
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