Ecdy Causes Cancer?
- 04-12-2011, 09:36 PM
- 04-13-2011, 12:51 AM
My initial foray into the abstracts leads me to believe that ecdysterone is actually anti-carcinogenic helping to lead to cancer cell aptosis.
Ecdysterone Modulates Antitumor Activity of Cytostatics and Biosynthesis of Macromolecules in Tumor-Bearing Mice
N. P. Konovalova, Yu. I. Mitrokhin, L. M. Volkova, L. I. Sidorenko and I. N. Todorov
The influence of therapeutic and half doses of cisplatin and adriamycin combination with the anabolic drug ecdysterone (20-hydroecdison) on development of subcutaneously and intraperitoneally transplanted P388 and L1210 leukemia and metastasizing B16 melanoma was studied. Ecdysterone significantly stimulated the chemotherapeutic effect of low doses of the cytostatics: inhibition of tumor growth, mice survival rate, their lifespan, and the antimetastatic activity index were comparable or better than after therapy with high doses of the antitumor drugs. The influence of high and low doses of cisplatin and its low dose in combination with ecdysterone on the dynamics of protein and DNA biosynthesis in the liver, pancreas, thymus, spleen, and adrenals of tumor-bearing mice were also studied. Although the therapeutic effect of 4 mg/kg cisplatin by activated protein biosynthesis and DNA repair is comparable or better than that of its low dose (2 mg/kg) in combination with ecdysterone, in terms of chemotherapy the combination looks preferable since the therapeutic dose of cisplatin is toxic for the intact tissues.
This is from a patent filing, note that beta-ecdysterone is listed for possible inclusion in a cancer therapy treatment:
Compositions of botanical extracts for cancer therapy
United States Patent Application 20050208070
The compositions can also be formulated with other active ingredients, such as anti-oxidants, vitamins (A, C, ascorbic acid, B's, such as B1, thiamine, B6, pyridoxine, B complex, biotin, choline, nicotinic acid, pantothenic acid, B12, cyanocobalamin, and/or B2, D, D2, D3, calciferol, E, such as tocopherol, riboflavin, K, K1, K2). Preferred compounds, include, e.g creatine monohydrate, pyruvate, L-Carnitine, α-lipoic acid, Phytin or Phytic acid, Co Enzyme Q10, NADH, NAD, D-ribose, amino acids such as L-glutamine, Lysine, chrysin; pre-hormones such as 4-androstenedione, 5-androstenedione, 4(or 5-)androstenediol, 19-nor-4 (or 5-)-androstenedione, 19-nor-4 (or 5-)-androstenediol, Beta-ecdysterone, and 5-Methyl-7-Methoxy Isoflavone. Preferred active ingredients include, e.g., pine pollen, fructus lycii, Hippophae rhamnoides, Ligusticum, Acanthopanax, Astragalus, Ephedra, codonopsis, polygola tenuifolia Willd, Lilium, Sparganiuma , ginseng, panax notogiseng, Garcinia , Guggle, Grape Seed Extract or powder, and/or Ginkgo Biloba.
Not related to cancer but I found this interesting as mitochondrial maintenance/support supplementation is a focus of life extension supplementation.
Rhaponticum carthamoides ( Leuzea carthamoides , or Maral Root) contains a mixture of compounds called ‘levseins’. Levseins represents a complex of more than 10 ecdysterones including 20-beta-ecdysterone, makisterone C, 24-dehydromakisterone A, carthamosterone, polypodyne B and ajugasterone C. Researchers extracted and purified various ecdysteroids from Rhaponticum and found that the ecdysteroids increased the muscle mass in a dose-dependent manner, with the rate of increase proportional to the ecdysteroids content. Ecdysteroids normalize NADH dehydrogenase activity, enzyme which catalyses NADH electron transfer to the ubiquinone in the oxidative phosphorylation processes at the mitochondrial level, contributing to buildup the electrochemical potential used to produce ATP. It also normalizes the succinate dehydrogenase activity, enzyme which acts in the tricarboxilic acid cycle, which translates in ATP synthesis and patient energy level increases [Tashmukhamedova M A, Almatov K T, Syrov V N. Comparative study of the effect of ecdysterone, turkesterone and nerobol on the function of rat liver mitochondria in experimental diabetes. Vopr Med Khim. 1986; 32:24-8]. Incorporation of this phytomedicine provides at least 10 active principles in a single therapeutic.
There were some other papers relating to cancer cell aptosis and ecdysterone, but I didn't have access to the full text and ecdysterone's role wasn't covered in the abstract.
- 04-13-2011, 01:11 AM
04-13-2011, 10:34 AM
So here is the only negative study I could find regarding ecdysterone and cancer; it regards the proliferation of breast cancer cells which have the estrogen receptor alpha. Note: T47D = Human ductal breast epithelial tumor cell line - Whole Cell Lysate
Influence of isopsoralen and ecdysterone on T47D cell proliferation and ER subtype expression of human breast cancer
ZHAO Pi-wen,NIU Jian-zhao,WANG Ji-feng,et al.(School of Fundamental Medical Sciences,Beijing University of Chinese Medicine, Beijing 100029)
Objective To observe the effects of isopsoralen and ecdysterone on the proliferation of T47D cells and detect their influence on the expressions of T47D subtypes-estrogen receptor α(ERα) and estrogen receptor β(ERβ) cells in human breast cancer.Methods The influence of isopsoralen and ecdysterone(the active principles of Fructus Psoraleae,Radix Cyathulae) on the proliferation of ERα and ERβ cells and on the expression levels of ERα and ERβ mRNA by MTT assay and RT-PCR respectively.The changes of cell proliferation cycle were detected by flow cytometry.Results Isopsoralen and ecdysterone(in dose of 10-6 mol/L and 10-7 mol/L respectively) promoted obviously the proliferation of cultured T47D cells,increased the proliferation indexes with an estrogenic effect.The result of RT-PCR showed that isopsoralen(10-6 mol/L) and ecdysterone(10-7 mol/L) improved the expression of ERα mRNA and isopsoralen improved the expression of ERβ mRNA at the same time.Conclusion Isopsoralen and ecdysterone have the phytoestrogenic effects and can influence the mRNA expression level of ER subtype.
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I'm not rushing to any negative conclusions because of the above study. Other studies have shown that ecdysterone encourages tumor cell aptosis in prostrate cancer.
04-13-2011, 05:23 PM
I've used and researched ecdy for years. I love the concept of a product with an almost unlimited health benefits that can also build muscle. I have even mega dosed on the stuff. The problem is that the oral bioavailability is very poor. I just finished a 4 week run of E-Bol from Thermo life and did not notice any increase in muscle mass or any leaning effect. But It does provide a deep and restful night’s sleep. In fact, if I dose too high prior to bedtime I'm groggy the next morning. From what I can discern the Russians injected the stuff. I have even read excerpts where modern day bodybuilders have injected ecdy with great results. It obviously has to be modified in order to be injected.
04-13-2011, 09:42 PM
Thanks for posting sapentia. That definitley makes me feel a little better. Maybe Vaughn will also get around to responding one day.
04-13-2011, 11:30 PM
04-14-2011, 02:22 PM
just wondering why dont people just drink grapefruit juice to help with the digestion and biovaliablity of Ecdy?
04-14-2011, 02:29 PM
I haven't responded because there isn't much to respond to. Any compound in its pure form will have an MSDS which claims it can be harmful if inhaled or touched with skin. This is true for caffeine...vitamin c...everything. Ecdy can not and will not cause cancer.
Hi-Tech Pharmaceuticals Representative Manager
04-14-2011, 04:17 PM
04-14-2011, 04:27 PM
04-14-2011, 04:28 PM
you apparently did not look at a caffeine MSDS as I told you to...
WARNING! HARMFUL IF SWALLOWED OR INHALED. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. POSSIBLE BIRTH DEFECT HAZARD. MAY CAUSE BIRTH DEFECTS BASED ON ANIMAL DATA.
SAF-T-DATA(tm) Ratings (Provided here for your convenience)
Health Rating: 2 - Moderate (Poison)
Flammability Rating: 1 - Slight
Reactivity Rating: 1 - Slight
Contact Rating: 2 - Moderate
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES
Storage Color Code: Blue (Health)
so to handle caffeine, we need goggles, lab coat, and gloves...omg!
Hi-Tech Pharmaceuticals Representative Manager
04-14-2011, 04:30 PM
It is not that I am not interested...it is that there is nothing for me to add to this. I am correct in saying that just about EVERY pure chemical has a MSDS that claims it can be harmful. Ecdy is not unique in this matter(as can be seen above).
Hi-Tech Pharmaceuticals Representative Manager
04-14-2011, 05:23 PM
04-14-2011, 05:45 PM
Actually I did, and I would gladly post up the links if I had enough posts to do it. It was obviously something different than you found however. I do appreciate you posting up the link though, because I can see what you mean now. It isnt so concerning when caffeine also includes those warnings. Since the national cancer institute "suspects" it may be a carcinogen, then it would have the potential to cause cancer, if it indeed was a carcinogen. I'd like to know what "suspect" means to them though. Oh well, this makes me feel alot better about taking the Ecdy I got the other day..after 2 days taking it, my muscles DO feel fuller. Still haven't gone to the gym yet, but I'm expecting a great pump.
04-14-2011, 05:50 PM
04-15-2011, 03:00 PM
We must also understand that ecdy was been around for years and people have been using various forms of it. Hell, we see studies on those that bypassed their hepatic system which acts to detoxify things we ingest and put it straight into their muscle cells (fibers) via IM injection. Basically what I'm saying is that we need to look at the whole picture, not just small selections of it. We try to put out the highest quality products that we can and don't sacrifice health for a quick sale.
Serious Nutrition Solutions rep
04-15-2011, 05:45 PM
04-15-2011, 06:55 PM
Because there is EDCY in spinach you could SUSPECT that could be the cause, based on knowledge about the other components of spinach, but that would be reason to conduct a specific test to find evidence.
Since SOO many things can be potentially linked to cancer, almost regardless of how big a test group is, other effects can possible skew result, so a very focused study is required to produce any useful information.
04-20-2011, 01:58 AM
Interesting discussion. Anybody have any good logs with the stuff yet?
Wondering about the iforce dosage vs other companies. Iforce is way more potent. But damn I think I've seen 300mg pills from other companies.
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