I take it with meal #2 for (5 hours after I wake) as I take a stim first thing in the AM. No real logic other than if I am going tio replenish the adrenals, I think it would make better sense to do so after they've been depleted (Stim use). I also would not advice taking this before sleep b/c elevated cortisol levels can blunt sleep. Additionally, some may experience an uptick in energy from use, so one more caution against taking pre-bed.
You know how I know this stuff works (along with Re-Set AD). Elevated cort levels cause hunger. for me, it's nuts. Any time I was placed on corticosteroid injects or the oral version (Medrol/Methylprednisolone) my appetite is unparalleled. Non stop. Well, I've taken 3 caps of the ReVamp and ReSet on days where I feel my adrenals were trashed, and it never fails, my appetite goes thru the roof. These supps indirectly increase cortisol, hence the similar hunger phenomenon.