Slin-Sane Question

[papagunz]

Firstly, I'd like to say I'm interested in the stuff. I tend to respond well to GDAs and the price is incredibly fair. I just have one question.

Why the norvaline? It has currently been established that arginine is pretty much useless for upping NO in healthy humans. Norvaline is an arginase inhibitor, so really its just another way of increasing plasma arginine.... so what am I missing?

Does it do more than inhibit arginase?

 

[dsade]

Arginine suffers (basically) two fates...degraded by Arginase or converted by iNOS into NO. While exogenous arginine doesn't necessarily change this bottleneck, inhibiting Arginase does.

 

[XplodeWithMe]

Think of it like this... inhibiting the arginase will only give you the one option to go to N.O.

Simple process of elimination to get to where you wanna go

 

[papagunz]

Arginine suffers (basically) two fates...degraded by Arginase or converted by iNOS into NO. While exogenous arginine doesn't necessarily change this bottleneck, inhibiting Arginase does.

Makes sense, thanks guys.

One more follow-up question. Is iNOS expression constitutive or inducible? (if inducible, via what pathway/molecule?) Again, not trying to be a stick in the mud, just trying to learn.

 

[dsade]

Makes sense, thanks guys.

One more follow-up question. Is iNOS expression constitutive or inducible? (if inducible, via what pathway/molecule?) Again, not trying to be a stick in the mud, just trying to learn.

iNOS mean inducible.

I'm not sure that the mechanism off activation has entirely been discovered.

 

[papagunz]

iNOS mean inducible.

I'm not sure that the mechanism off activation has entirely been discovered.

Oh, ok. I was thinking more along the lines of 'intra' something or generally a location. (like 'e'NOS is for 'endothelial' cells)

Thank you for the speedy response.