Too many variables for one difinitive answer. I like joint locks/arm bars personally as I can obtain and maintain control of my opponent and either take him completly to the ground or keep him partially upright to act as a shield against multiple attackers. (After softening them up of course. Perhaps an eye strike, groin kick, ear slap, etc.) An upper fake hook as I twist into a low downward round kick targeting the side of the knee can be quite effective as well. Personally, I would predominately only be fighting for self defense and I would match force with the apparent intent of the would be assailant. You strike at my throat and I am going to assume you mean me grave harm. Expect deadly blows reciprocated ad hoc. You have a knife, forget about it, dead man walking.
Chances are, if you are asking this question, any attempt to take someone down who has a fair amount of training may not end up in your favor.