If caught in the early stages, stretch marks can be minimised with over-the-counter moisturising creams. Vitamin E oil, which assists in general skin healing and condition, can reduce the appearance of stretch marks. Vitamin A is also a good emollient, but it's not as effective as prescription Tretinoin, or Retin-A, which attaches itself to receptors on the skin cells and helps exfoliate the skin and form healthy new cells. Though these creams are effective in moisturising the outer skin layer, they can't always penetrate deep into the dermis where stretch marks occur. They also can't completely change a pre-existing skin condition, which is why they work best on stretch marks that are just forming.