So I am looking to smoke out more than I have in the past. Is marijuana tolerance more a psychological problem of getting used to it or a physical thing?
its physical in my experience, like caffeine.
There are cannabinoid receptors. With any receptor, when you saturate it with an agonist, the body produces fewer receptors. If you take an antagonist the body produces more receptors and you become more sensitive. I don't think being on a CB1 antagonist is particularly fun. However, after a short time on a CB1 antagonist you would be SUPER sensitive to THC.
Back.... for real this time
maybe memantine would reduce tolerance to weed like it does amphetamines and benzos? i know that being on 2.5mg EOD of deprenyl seems to work good for my marijuana tolerance.
Is there a reason your "looking to smoke out more, than in the past"?
By the way, I used to only smoke like once a month, so Im still not neccesarily planning on becoming a stoner.
heard/read somewhere that 7,8 benzoflavone(like in sustain alpha) lowers tolerance.
The Truth is, there is no Truth.
I know that there are medical benefits on using MJ but abusing it can cause damage to your brain.
Back.... for real this time
You can smoke every day for years, come off of it and you'll be back to normal in a week or so. Then after a month you'll be completely clean. There has never been a legit study to definitely show that MJ use damages brain tissue. Now, studies they did on MJ way back in the day were used mostly for propaganda, so it was common to hear that MJ use caused all kinds of problems. This is one of the biggest reasons why it's illegal... Propaganda. Go watch that film called "Reefer Madness." They basically said that if you used MJ you were likely to go ****ing nuts. It's kind of funny, but kind of ****ty because of the negative stigma it put on MJ.
I've been drunk and I've been really high plenty of times. I can tell you that without a shadow of a doubt that I could NEVER get as messed up on pot as I could on alcohol. Even if you're just "buzzed" off of alcohol, you'll be more messed up than if you were super high. Even if you're smoking really potent stuff and it's your first time, you won't get as messed up as you would if you were to get drunk. The best thing about pot is that after you're high and you come down, that's it, you don't have a hangover; maybe a little sleepiness, but wow, that's it. I'm sure most of you know the after effects of alcohol. Hell, if you just smoke every once in a while you usually feel great the next day.
Some people can do it very responsibly. And you can tell when someone comes into work after drinking a 12 pack the night before, you cant tell who lit up a couple J's and relaxed. Hell some of the most intelligent people I know smoke just to slow their thoughts, relax their mind, and yet they are still computer geniuses and can build one from the ground up while high. Lets see someone do that properly after 10 rounds with Jose.
The only reason it is illegal is because it can grow in almost any circumstance, can be used as an alternative to paper, and is linked to Many medical "points of interest" even to being able to "freeze" cancer if a certain extract of it is used.
Anything that beneficial and cheap is instantly banned because the people in charge cant make $$ ripping people off.
Rumor I heard was Cali (our Governator) is looking into legalizing it soon. Which when it does, step by step the rest of the states will. Honestly when its legal, I may hit it up again every once in awhile. But in its current illegal state, I wont touch it.
Ask around and you will be surprised how many people are in your position thanks to the economy and hard times. I am 23 still have a room with my parents(though should be moved out withing the next 4-6) and am going through some hellish times and have to make certain live moves that will effect me for the rest of this life financially, just to survive.
Dont turn to any substance to cope though bro. Use lifting, or develop some skills in different areas. It will all come to pass. As a man who has been counselling me said, "This too shall pass", for he was there for me when my hell began 4 years ago.
If you need to talk, well I think I can feel you on your situation.
brain damage occured in studies where monkeys smoked (continuously) up to 80 joints through a gas mask without being given any outside air to breathe. you can smoke that much oregano and i bet your brain will never be the same.
When a drug causes the dopamine receptors to fire off without regular stimulus (eating, getting laid, watching your kid walk for the first time,etc..) the dopamine receptors don't work as well for the normal aspects of life.
Pot is fun times but let's not kid ourselves, it's a drug that causes brain damage.
Moderation is the key to enjoyment, at least in my experience.
I think this is the study... or I'm just reading it wrong...
Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn.--a brief perspective.
University Institute of Pharmaceutical Sciences, Panjab Univesity, Chandigarh, India. firstname.lastname@example.org
The present work is a mini-review of the author's original work on the plant Passiflora incarnata Linn., which is used in several parts of the world as a traditional medicine for the management of anxiety, insomnia, epilepsy and morphine addiction. A tri-substituted benzoflavone moiety (BZF) has been isolated from the bioactive methanol extract of this plant, which has been proposed in the author's earlier work to be responsible for the biological activities of this plant. The BZF moiety has exhibited significantly encouraging results in the reversal of tolerance and dependence of several addiction-prone psychotropic drugs, including morphine, nicotine, ethanol, diazepam and delta-9-tetrahydrocannabinol, during earlier pharmacological studies conducted by the author. In addition to this, the BZF moiety has exhibited aphrodisiac, libido-enhancing and virility-enhancing properties in 2-year-old male rats. When administered concomitantly with nicotine, ethanol and delta-9-tetrahydrocannabinol for 30 days in male rats, the BZF also prevented the drug-induced decline in sexuality in male rats. Because the BZF moiety isolated from P. incarnata is a tri-substituted derivative of alpha-naphthoflavone (7,8-benzoflavone), a well-known aromatase-enzyme inhibitor, the mode of action of BZF has been postulated to be a neurosteroidal mechanism vide in which the BZF moiety prevents the metabolic degradation of testosterone and upregulates blood - testosterone levels in the body. As several flavonoids (e.g. chrysin, apigenin) and other phytoconstituents also possess aromatase-inhibiting properties, and the IC50 value of such phytomoieties is the main factor determining their biochemical efficacy, by altering their chemical structures to attain a desirable IC50 value new insights in medical therapeutics can be attained, keeping in view the menace of drug abuse worldwide.
PMID: 14690874 [PubMed - indexed for MEDLINE]
The Truth is, there is no Truth.
Reversal of cannabinoids (delta9-THC) by the benzoflavone moiety from methanol extract of Passiflora incarnata Linneaus in mice: a possible therapy for cannabinoid addiction.
Dhawan K, Kumar S, Sharma A.
Pharmacognosy Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
The newly reported benzoflavone moiety from the plant Passiflora incarnata Linneaus has been evaluated in light of traditional reports on the use of P. incarnata in breaking down cannabis addiction. In the modern or allopathic system of therapeutics, there has been no suitable remedy to combat the severe withdrawal effects of various cannabis products, including marihuana, marijuana, bhang, hashish, ganja, etc., the world-wide consumption of which has attained alarming proportions especially among the younger generation. Mice were given a 10-mg-kg(-1) twice-daily dose of delta9-tetrahydrocannabinol (delta9-THC) by mouth for six days to make them dependent upon cannabinoids. Concurrently, other groups of mice were administered delta9-THC along with a 10- or 20-mg-kg(-1) twice-daily dose of the benzoflavone moiety from P. incarnata orally for 6 days. Upon measuring locomotor activity during the treatment regimen, it was noticed that the mice receiving the P. incarnata extract and delta9-THC together developed significantly less tolerance and dependence, relative to the mice receiving delta9-THC alone. Upon administration of SR-141716A, a selective cannabinoid-receptor antagonist (10 mg kg(-1), p.o.) to all the groups of mice on the 7th day, an artificial withdrawal was produced due to an abrupt decline of delta9-THC levels in mouse brain. However, the typical withdrawal effects like paw tremors and head shakes were significantly less in the mice given delta9-THC+P. incarnata benzoflavone moiety for 6 days. Upon administration of 20 mg kg(-1) of the P. incarnata benzoflavone moiety to mice showing severe symptoms of withdrawal due to administration of SR-141716A, there was a marked attenuation of withdrawal effects, thereby suggesting the usefulness of the benzoflavone moiety in delta9-THC withdrawal. Thus, the benzoflavone moiety of P. incarnata, when administered concurrently with delta9-THC, prevented the development of tolerance and dependence of cannabinoids in mice. Even an acute administration of the benzoflavone moiety (20 mg kg(-1), p.o.) significantly blocked the expression of withdrawal effects in delta9-THC-dependent mice.
* Comparative Study
* Research Support, Non-U.S. Gov't
PMID: 12079005 [PubMed - indexed for MEDLINE]
The Truth is, there is no Truth.
I'm gonna start doing some more research on this benzoflavone moiety