marijuana tolerance

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    marijuana tolerance


    So I am looking to smoke out more than I have in the past. Is marijuana tolerance more a psychological problem of getting used to it or a physical thing?

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    its physical in my experience, like caffeine.
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    There are cannabinoid receptors. With any receptor, when you saturate it with an agonist, the body produces fewer receptors. If you take an antagonist the body produces more receptors and you become more sensitive. I don't think being on a CB1 antagonist is particularly fun. However, after a short time on a CB1 antagonist you would be SUPER sensitive to THC.
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    maybe memantine would reduce tolerance to weed like it does amphetamines and benzos? i know that being on 2.5mg EOD of deprenyl seems to work good for my marijuana tolerance.
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    Is there a reason your "looking to smoke out more, than in the past"?
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    Quote Originally Posted by lonewolf0420 View Post
    Is there a reason your "looking to smoke out more, than in the past"?
    Thanks for asking. I have a few reasons. Helps with joints, helps relax to sleep when my house is noizy(spelling) and although this wasnt my life plan, I'm still living with my parents at the age of 24. I know I'm not that old, but my 32yo brother just got out of jail, and he has the room with all the privacy. If I ever whant to be a sexual creature, I'm gonna need some type of social lubricant so that Im not a paranoid mess over the fact that I basically can't have a private conversation without whispering.


    By the way, I used to only smoke like once a month, so Im still not neccesarily planning on becoming a stoner.
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    heard/read somewhere that 7,8 benzoflavone(like in sustain alpha) lowers tolerance.
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    I know that there are medical benefits on using MJ but abusing it can cause damage to your brain.
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    Quote Originally Posted by bound View Post
    heard/read somewhere that 7,8 benzoflavone(like in sustain alpha) lowers tolerance.
    Interesting. I assume this is broscience, right? No studies about MJ and sustain alpha, right?

    Quote Originally Posted by TipTopShape View Post
    I know that there are medical benefits on using MJ but abusing it can cause damage to your brain.
    I think the damage is short term but I agree. If things aren't going well in life i do not recommend smoking more pot as a solution.
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    Quote Originally Posted by TipTopShape View Post
    I know that there are medical benefits on using MJ but abusing it can cause damage to your brain.
    Not necessarily true.

    You can smoke every day for years, come off of it and you'll be back to normal in a week or so. Then after a month you'll be completely clean. There has never been a legit study to definitely show that MJ use damages brain tissue. Now, studies they did on MJ way back in the day were used mostly for propaganda, so it was common to hear that MJ use caused all kinds of problems. This is one of the biggest reasons why it's illegal... Propaganda. Go watch that film called "Reefer Madness." They basically said that if you used MJ you were likely to go ****ing nuts. It's kind of funny, but kind of ****ty because of the negative stigma it put on MJ.

    I've been drunk and I've been really high plenty of times. I can tell you that without a shadow of a doubt that I could NEVER get as messed up on pot as I could on alcohol. Even if you're just "buzzed" off of alcohol, you'll be more messed up than if you were super high. Even if you're smoking really potent stuff and it's your first time, you won't get as messed up as you would if you were to get drunk. The best thing about pot is that after you're high and you come down, that's it, you don't have a hangover; maybe a little sleepiness, but wow, that's it. I'm sure most of you know the after effects of alcohol. Hell, if you just smoke every once in a while you usually feel great the next day.
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    Quote Originally Posted by Type O Hero View Post

    I've been drunk and I've been really high plenty of times. I can tell you that without a shadow of a doubt that I could NEVER get as messed up on pot as I could on alcohol. Even if you're just "buzzed" off of alcohol, you'll be more messed up than if you were super high. Even if you're smoking really potent stuff and it's your first time, you won't get as messed up as you would if you were to get drunk. The best thing about pot is that after you're high and you come down, that's it, you don't have a hangover; maybe a little sleepiness, but wow, that's it. I'm sure most of you know the after effects of alcohol. Hell, if you just smoke every once in a while you usually feel great the next day.
    I agree, I have done both. Alcohol being far more potent than the herb I have lit in my past. That being said, the stuff I did light was the best available on the market...(had a guy from vegas as a buddy at the time who only went high end and was only a party/stoner type).

    Some people can do it very responsibly. And you can tell when someone comes into work after drinking a 12 pack the night before, you cant tell who lit up a couple J's and relaxed. Hell some of the most intelligent people I know smoke just to slow their thoughts, relax their mind, and yet they are still computer geniuses and can build one from the ground up while high. Lets see someone do that properly after 10 rounds with Jose.

    The only reason it is illegal is because it can grow in almost any circumstance, can be used as an alternative to paper, and is linked to Many medical "points of interest" even to being able to "freeze" cancer if a certain extract of it is used.

    Anything that beneficial and cheap is instantly banned because the people in charge cant make $$ ripping people off.

    Rumor I heard was Cali (our Governator) is looking into legalizing it soon. Which when it does, step by step the rest of the states will. Honestly when its legal, I may hit it up again every once in awhile. But in its current illegal state, I wont touch it.
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    Quote Originally Posted by kingdong View Post
    Thanks for asking. I have a few reasons. Helps with joints, helps relax to sleep when my house is noizy(spelling) and although this wasnt my life plan, I'm still living with my parents at the age of 24. I know I'm not that old, but my 32yo brother just got out of jail, and he has the room with all the privacy. If I ever whant to be a sexual creature, I'm gonna need some type of social lubricant so that Im not a paranoid mess over the fact that I basically can't have a private conversation without whispering.


    By the way, I used to only smoke like once a month, so Im still not neccesarily planning on becoming a stoner.
    Also my friend, do not stress over this...

    Ask around and you will be surprised how many people are in your position thanks to the economy and hard times. I am 23 still have a room with my parents(though should be moved out withing the next 4-6) and am going through some hellish times and have to make certain live moves that will effect me for the rest of this life financially, just to survive.

    Dont turn to any substance to cope though bro. Use lifting, or develop some skills in different areas. It will all come to pass. As a man who has been counselling me said, "This too shall pass", for he was there for me when my hell began 4 years ago.

    If you need to talk, well I think I can feel you on your situation.
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    ?OMFG!! REALLY
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    brain damage occured in studies where monkeys smoked (continuously) up to 80 joints through a gas mask without being given any outside air to breathe. you can smoke that much oregano and i bet your brain will never be the same.
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    When a drug causes the dopamine receptors to fire off without regular stimulus (eating, getting laid, watching your kid walk for the first time,etc..) the dopamine receptors don't work as well for the normal aspects of life.
    Pot is fun times but let's not kid ourselves, it's a drug that causes brain damage.
    Quote Originally Posted by madds87 View Post
    Im not to fond of taking serm's for long periods of time....
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    Moderation is the key to enjoyment, at least in my experience.
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    Quote Originally Posted by Fastone View Post
    Moderation is the key to enjoyment, at least in my experience.
    Agreed. Everything in moderation.
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    I think this is the study... or I'm just reading it wrong...

    Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn.--a brief perspective.
    Dhawan K.

    University Institute of Pharmaceutical Sciences, Panjab Univesity, Chandigarh, India. kdd@glide.net.in

    Abstract
    The present work is a mini-review of the author's original work on the plant Passiflora incarnata Linn., which is used in several parts of the world as a traditional medicine for the management of anxiety, insomnia, epilepsy and morphine addiction. A tri-substituted benzoflavone moiety (BZF) has been isolated from the bioactive methanol extract of this plant, which has been proposed in the author's earlier work to be responsible for the biological activities of this plant. The BZF moiety has exhibited significantly encouraging results in the reversal of tolerance and dependence of several addiction-prone psychotropic drugs, including morphine, nicotine, ethanol, diazepam and delta-9-tetrahydrocannabinol, during earlier pharmacological studies conducted by the author. In addition to this, the BZF moiety has exhibited aphrodisiac, libido-enhancing and virility-enhancing properties in 2-year-old male rats. When administered concomitantly with nicotine, ethanol and delta-9-tetrahydrocannabinol for 30 days in male rats, the BZF also prevented the drug-induced decline in sexuality in male rats. Because the BZF moiety isolated from P. incarnata is a tri-substituted derivative of alpha-naphthoflavone (7,8-benzoflavone), a well-known aromatase-enzyme inhibitor, the mode of action of BZF has been postulated to be a neurosteroidal mechanism vide in which the BZF moiety prevents the metabolic degradation of testosterone and upregulates blood - testosterone levels in the body. As several flavonoids (e.g. chrysin, apigenin) and other phytoconstituents also possess aromatase-inhibiting properties, and the IC50 value of such phytomoieties is the main factor determining their biochemical efficacy, by altering their chemical structures to attain a desirable IC50 value new insights in medical therapeutics can be attained, keeping in view the menace of drug abuse worldwide.

    PMID: 14690874 [PubMed - indexed for MEDLINE]
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    Here's another:

    Reversal of cannabinoids (delta9-THC) by the benzoflavone moiety from methanol extract of Passiflora incarnata Linneaus in mice: a possible therapy for cannabinoid addiction.

    Dhawan K, Kumar S, Sharma A.

    Pharmacognosy Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.

    The newly reported benzoflavone moiety from the plant Passiflora incarnata Linneaus has been evaluated in light of traditional reports on the use of P. incarnata in breaking down cannabis addiction. In the modern or allopathic system of therapeutics, there has been no suitable remedy to combat the severe withdrawal effects of various cannabis products, including marihuana, marijuana, bhang, hashish, ganja, etc., the world-wide consumption of which has attained alarming proportions especially among the younger generation. Mice were given a 10-mg-kg(-1) twice-daily dose of delta9-tetrahydrocannabinol (delta9-THC) by mouth for six days to make them dependent upon cannabinoids. Concurrently, other groups of mice were administered delta9-THC along with a 10- or 20-mg-kg(-1) twice-daily dose of the benzoflavone moiety from P. incarnata orally for 6 days. Upon measuring locomotor activity during the treatment regimen, it was noticed that the mice receiving the P. incarnata extract and delta9-THC together developed significantly less tolerance and dependence, relative to the mice receiving delta9-THC alone. Upon administration of SR-141716A, a selective cannabinoid-receptor antagonist (10 mg kg(-1), p.o.) to all the groups of mice on the 7th day, an artificial withdrawal was produced due to an abrupt decline of delta9-THC levels in mouse brain. However, the typical withdrawal effects like paw tremors and head shakes were significantly less in the mice given delta9-THC+P. incarnata benzoflavone moiety for 6 days. Upon administration of 20 mg kg(-1) of the P. incarnata benzoflavone moiety to mice showing severe symptoms of withdrawal due to administration of SR-141716A, there was a marked attenuation of withdrawal effects, thereby suggesting the usefulness of the benzoflavone moiety in delta9-THC withdrawal. Thus, the benzoflavone moiety of P. incarnata, when administered concurrently with delta9-THC, prevented the development of tolerance and dependence of cannabinoids in mice. Even an acute administration of the benzoflavone moiety (20 mg kg(-1), p.o.) significantly blocked the expression of withdrawal effects in delta9-THC-dependent mice.

    Publication Types:

    * Comparative Study
    * Research Support, Non-U.S. Gov't


    PMID: 12079005 [PubMed - indexed for MEDLINE]

    http://www.ncbi.nlm.nih.gov/pubmed/1...?dopt=Abstract
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    I'm gonna start doing some more research on this benzoflavone moiety
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    Quote Originally Posted by lonewolf0420 View Post
    I'm gonna start doing some more research on this benzoflavone moiety
    Note that benzoflavone is in sustain alpha.
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    Nothing better for relaxing before bed and ensuring a good night's sleep.
    Just inject.
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    Quote Originally Posted by HereToStudy View Post
    Nothing better for relaxing before bed and ensuring a good night's sleep.
    Except weed actually prevents REM sleep. Buzzkill!!!!!!!!!!!

    I <3 da herb but yeah you'll get a tolerance, much more mentally than physically. if you're smoking good **** you won't get tolerant of it unless you're smoking yourself retarded consistently on a daily basis.

    i'm on probation so I have to stick to my own JWH blend, which is not yet illegal. YET i don't know how many of the guys here would be interested but we just started manufacturing and are going to launch the product in a few weeks. real american broski's making real american fake ganja, right here in the good ol' US of A. we'll throw out some samples and it'll be a lot cheaper than that euro BS in all the headshops now. just pm me if you're interested, i know a lot of dudes here might be

    btw OP made me laugh, i needed that after work so thank you
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    Quote Originally Posted by TxHomeGrown View Post
    i'm on probation so I have to stick to my own JWH blend, which is not yet illegal. YET
    I thought the legal herb blends that work were no longer legal in US and was mostly a U.K. thing?
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    Quote Originally Posted by HereToStudy View Post
    I thought the legal herb blends that work were no longer legal in US and was mostly a U.K. thing?
    same here.
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    Quote Originally Posted by HereToStudy View Post
    I thought the legal herb blends that work were no longer legal in US and was mostly a U.K. thing?
    No sir. The analogue act pertains to substances that are sold for human consumption. As long as the product is sold with a disclaimer that says, "NOT FOR HUMAN CONSUMPTION" the analogue act does not apply. It's kind of like head shops selling pipes/bongs for tobacco use only
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    Haha.. I just pictured the following:

    Hey man got a source for some bud online?
    Shh..you cant mention sources on these boards, just google "research plants," and you will find everything you need.

    This lifestyle makes me feel more shady by the minute lol
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    legal buds...what a tease!! I dont think i could do it, i would probably just stop if I was on probation.
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    Quote Originally Posted by AntonG42O View Post
    legal buds...what a tease!! I dont think i could do it, i would probably just stop if I was on probation.
    it shouldn't be legal. stuff gets you ripped!
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    Quote Originally Posted by TxHomeGrown View Post
    it shouldn't be legal. stuff gets you ripped!
    wait what? really? how are they selling it through high times, etc?
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    Quote Originally Posted by AntonG42O View Post
    wait what? really? how are they selling it through high times, etc?
    yes. the blends that get you ripped contain a synthetic cannabinoid, undetectable and legal.
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    I think constant use has left my brain producing very little dopamine of its own.
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    Quote Originally Posted by lonewolf0420 View Post
    I think constant use has left my brain producing very little dopamine of its own.
    me too. today is day 1 of stopping/detox. its been at least 4 years of everyday use. my brain is acting weird and this $hit is costing too much money. oh man this week is gonna be rough...
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    I quit the same way about 4 years ago. It was like something was missing at first and sucked at night, but after a couple weeks I realized when I was always high, I missed out on reality. It's like a cloud was lifted from my head when I quit. Stick with it dude
    Quote Originally Posted by madds87 View Post
    Im not to fond of taking serm's for long periods of time....
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    Happy 420
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    Quote Originally Posted by CrazyChemist View Post
    Happy 420
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    Quote Originally Posted by timmmah View Post
    I quit the same way about 4 years ago. It was like something was missing at first and sucked at night, but after a couple weeks I realized when I was always high, I missed out on reality. It's like a cloud was lifted from my head when I quit. Stick with it dude
    thanks man, took me about 2 hours to fall asleep last night. i made sure i sweated out an extra bucket of sweat at BJJ. im feeling pretty $hitty now, I gotta get away from this environment because most people I hang out with smoke. im drinking gallons and gallons of water, started doing apple cider vinegar, high dosing vitamin C, gonna go pick up some valerian root today. anyone else have any tips? sorry this is off topic
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    Quote Originally Posted by lonewolf0420 View Post
    Celebrate. I actually did yesterday, but will be attending a baseball game today, so might have a brew or two.
    Just inject.
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    Can't wait to go home and rip a bong.

    My tolerance is nothing compared to what it used to be. Back in high school i'd smoke before school, at lunch, and after school.

    But now I get really awesome weed (back then was just mid-grade)...**** is like crack i just take a few hits and i'm high as a motherf*cker.
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    Ok I nearly died when viewing this:
    Just inject.
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