I posted in the weight loss section the same question, so I might know a thing or two. After 12 miles in 2 days which was different then the 3 miles average in 2 days I was hurting. Taking it easy and I took glucosomine, cod liver oil, vitamin E, glutamine 2 times a day. I have bad knees from a couple of years of intense football and basketball abuse on my knees (spend half the time on the floor). This combo has worked a little as I didn't continue the trend of 6 miles a day.
Stretching is helping a lot, Esp pwo, i think it's more important post then pre. Just a 5 min warmup to get you sweating on the treadmill and some trunk rotations.
try those out, def helps with joints and cartalidge.
And take it ez, keep training, the pills only do so much, once you get back to the gym and after a little bit the caffeine will kick in and the problem goes away. (ampd helps along with mp3p to push through the pain) It goes away. but when u over do it, take some time off.
gl,
Kam