anoopbal
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‘Muscle memory’ has always been a mystery. But now it seems like we finally have an answer. Check out the new article: Muscle Memory Solved
Yup. More excuse to play with mgf and igf-1 now.‘Muscle memory’ has always been a mystery. But now it seems like we finally have an answer. Check out the new article: Muscle Memory Solved
No. It was the other way around. It was accepted that muscle lose nuclei with muscle loss and is consistent with the 'nuclear domain theory'. This in fact goes against it.In a totally non "i knew first" kind of way.
Im pretty sure this was well known before this was published? I remember thinking about this on my cycle last summer and I've posted about increased nuclei from cycle permanently increasing genetic potential before here on AM.
Few previous studies from dat's site. 2008/2010:Thanks pumphouse and Jennifer,
No. It was the other way around. It was accepted that muscle lose nuclei with muscle loss and is consistent with the 'nuclear domain theory'. This in fact goes against it.
Those were the same studies referenced in the article. In fact, there is a recent one in 2012 which showed the same with hindlimb unloading. So they are using different models to confirm it.Few previous studies from dat's site. 2008/2010:
Bruusgaard JC, Gundersen K. In vivo time-lapse microscopy reveals no loss of murine myonuclei during weeks of muscle atrophy, J Clin Invest 118: 1450–1457, 2008
Bruusgaard JC, Johansen IB, Egner IM, Rana ZA, Gundersen K. Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining, Proc Natl Acad Sci USA 107: 15111–15116, 2010
Gundersen K, Bruusgaard JC. Nuclear domains during muscle atrophy: nuclei lost or paradigm lost?, J Physiol 586: 2675–2681, 2008
Unfortunately u know this from first hand experience. I was diagnosed with nerve damage in my entire body and basically had to rebuild all my muscles back up. I lost a total of 30lbs and am coming up on 6months of being in.a rehabilitation center. My upper body has basically returned to almost normal before diagnosis. My legs still requires a lot of, not rehab per se but strengthening that I basically do on leg press and leg extension machines. My major issue is dorsiflexion.haha yep.
This might be good for people who lost muscle due to bed rest and due to disease. Maybe in disease it could be in another mechanism. I remember when I was doing my Master's it was pretty accepted in our lab that muscle lose around 30% of nuclei during atrophy and the 'domain theory' was pretty intact. So this is pretty cool.
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