This is such a loaded question, especially since we all know there is no one magic routine.
First, I think you need to define what type of hypertrophy you are looking to accomplish: sarcoplasmic or myofibril.
Second, it is much easier to increase one aspect while maintaining the other versus attempting to increase both at once. This is why periodization, especially non-linear periodization is so productive.
Third, a battery of tests can be done to see which mechanism of hypertrophy an individual may respond best to.
In general, sarcoplasmic hypertrophy (the increasing of intracellular organelles, the merging of satellite cells with the myofiber, and an increase in sarcoplasm) generally results from higher rep ranges with lower rest periods.
Myofibrillar hypertrophy (the increasing in number and density of contractile proteins), on the other hand, generally occurs with lower rep ranges and longer rest periods.
Personally, I have had the best results utilizing a 6 week mesocycle with 2 week microcycles. Week 1-2: increase sarcoplasmic hypertrophy, maintain myofibril and strength/power. Week 3-4: increase myofibril while maintaining sarcoplasmic and strength/power. Week 5-6: increase strength and power while maintaining hypertrophy gains. Week 7 deload.
If you want to get more specific, you can focus on increasing different aspects in different body parts of movements; but this can be complicated for most amatuer trainees.
Br