There is still one ingredient we are trying to finalize that we have left off of the writeup. Ingredients should arrive soon, and we will have around 100 beta units available. The product will come as an oil suspension in an 8 ounce bottle, with a pointed dispenser tip with 270 000-sized (1cc) capsules. It should take but a few seconds to shake the bottle and fill 9 capsules for the day. Final product will be in softgel form. And here we go:
Brite Write Up
Brite Cell Overview
In order to fully understand the concept of EvoMuse Brite, a bit of background science will be beneficial before we get into the specific ingredients.
Many years ago, it was thought that adult mammalian fat cells (adipocytes) were all basically the same. Under a microscope, they appeared white (white adipose tissue, or WAT), and they did a great job at storing fat in case it needed to be used later during periods of hunger or famine. While much maligned by fitness enthusiasts, WAT is essential to our functioning and survival, and is actually quite beneficial when it works as intended. However, sometimes WAT becomes dysfunctional, and gets too good at storing fat, for various genetic and/or dietary reasons, leading to conditions of overweight and obesity.
Then came the discovery of brown fat (BAT) it rodents, which appeared to act quite differently from traditional WAT. Behaving in a contradictory fashion, BAT was actually shown to be dense in mitochondria, and therefore thermogenic. It was determined that these cells primary function was something called "non-shivering thermogenesis", involving a futile cycle of shuttling protons to the mitochondria to generate heat (1).
This got researchers excited, and they began to study BAT for anti-obesity purposes. Several years later, this was all but abandoned, due to the initial apparent lack of BAT cells in humans past infancy.
Fast forward to recent years, and it was discovered that adult humans actually do have a significant amount of BAT cells. The quantity is small in comparison to WAT cells, but as it turns out, you don't need a large volume of these fat-burning cells to instigate a significant metabolic effect. So researchers revisited BAT upregulation as an avenue to treat obesity.
Based on the most current research, we have now discovered another player in the adipocyte continuum. These are called "Brite" cells. At a microscopic level, brite cells display a color in-between BAT and WAT cells, although they behave similar if not almost the same as BAT. And unlike BAT, they are actually created within WAT cells.
These cells are currently referred to in the research by several names; brite, beige, inducible, recruitable-brown, and brown adipocyte-like cells. For the purpose of this write up, we will be referring to them as "brite"; a name derived from a combination of the words "brown-in-white".
While the research on brite cells is in its infancy, we do know enough about these fascinating metabolically active fat depots to take steps to encourage their activation and therefore fat burning potential. EvoMuse Brite has been developed with the goal of shifting those with the unfortunate fat storing phenotype to a more genetically lean, fat burning phenotype.
The goal is to convince the WAT cells currently in your body, to trigger the intracellular production of brite cells, so that instead of just being fat storage depots and adipokine factories, they will also actually burn fat.
Research has shown that the hormone irisin (endogenous or exogenous), might trigger brite cell formation, as well as cold therapy, but the evidence is quite often contradictory as far as effectiveness. One of the current lines of thought is that not all white cells have this potential to turn brite, but those that do are located in specific places in humans, particularly along the spine and around the collarbone. But like BAT cells, we don't need many of them to have a big effect. And it turns out; people genetically prone to fatness are likely to express less of these cells.
BAT mitochondria respond to something called UCP1 (uncoupling protein 1) to burn fat and generate heat, while brite cells seem to express lower levels of UCP1. However, brite cells potentially burn fat independently of UCP1 signaling, and furthermore, with the proper triggers, brite fat can actually turn on high levels of UCP1 (2). Multiple ingredients in the Brite formula will encourage WAT cells to upregulate UCP1 levels.
The research shows that once developed, these brite cells directly correlate with leanness and can likely reduce metabolic disease and obesity in humans (3).
With that background in mind, the next thing we want to look at is a fatty acid called CLnA.
Conjugated Linolenic Acid (CLnA)
By now most people are well aware of conjugated linoleic acid (CLA), and while a similar fatty acid, conjugated linolenic acid (CLnA) functions quite differently. CLnA is found naturally in several seed oils, but can also be produced in small amounts endogenously by gut bacteria.
Current research has demonstrated CLnA's unique potential for fat loss from multiple angles. We have multiple sources of CLnA in the Brite formula, but first lets look at a little background on the overall CLnA research.
In a recent review published in the journal Lipids, CLnA was found to exhibit anti-obeseogenic properties, as well as reducing inflammation, boosting immune function, and improving overall cardiovascular health (4).
The worst thing a WAT cell can do is become dysfunctional, which will reduce it's ability to become a brite cell and cause it to become highly efficient at excessive fat storage and poor at releasing stored fatty acids to be oxidized. Normal cellular functioning involves low oxidative stress, low lipid peroxidation, and low inflammation, with optimal levels of superoxide dismutase (SOD). CLnA administration has been shown to support all of these (5,6).
In a study comparing CLnA to CLA, animals had a higher beta-oxidation rate and lost more fat in the CLnA group (7). Another study showed that CLnA had an apoptotic effect on proliferating pre-adipocytes (8). From a general health perspective, CLnA has also been shown to protect LDL cholesterol from oxidation (9).
Brite Write Up
Brite Cell Overview
In order to fully understand the concept of EvoMuse Brite, a bit of background science will be beneficial before we get into the specific ingredients.
Many years ago, it was thought that adult mammalian fat cells (adipocytes) were all basically the same. Under a microscope, they appeared white (white adipose tissue, or WAT), and they did a great job at storing fat in case it needed to be used later during periods of hunger or famine. While much maligned by fitness enthusiasts, WAT is essential to our functioning and survival, and is actually quite beneficial when it works as intended. However, sometimes WAT becomes dysfunctional, and gets too good at storing fat, for various genetic and/or dietary reasons, leading to conditions of overweight and obesity.
Then came the discovery of brown fat (BAT) it rodents, which appeared to act quite differently from traditional WAT. Behaving in a contradictory fashion, BAT was actually shown to be dense in mitochondria, and therefore thermogenic. It was determined that these cells primary function was something called "non-shivering thermogenesis", involving a futile cycle of shuttling protons to the mitochondria to generate heat (1).
This got researchers excited, and they began to study BAT for anti-obesity purposes. Several years later, this was all but abandoned, due to the initial apparent lack of BAT cells in humans past infancy.
Fast forward to recent years, and it was discovered that adult humans actually do have a significant amount of BAT cells. The quantity is small in comparison to WAT cells, but as it turns out, you don't need a large volume of these fat-burning cells to instigate a significant metabolic effect. So researchers revisited BAT upregulation as an avenue to treat obesity.
Based on the most current research, we have now discovered another player in the adipocyte continuum. These are called "Brite" cells. At a microscopic level, brite cells display a color in-between BAT and WAT cells, although they behave similar if not almost the same as BAT. And unlike BAT, they are actually created within WAT cells.
These cells are currently referred to in the research by several names; brite, beige, inducible, recruitable-brown, and brown adipocyte-like cells. For the purpose of this write up, we will be referring to them as "brite"; a name derived from a combination of the words "brown-in-white".
While the research on brite cells is in its infancy, we do know enough about these fascinating metabolically active fat depots to take steps to encourage their activation and therefore fat burning potential. EvoMuse Brite has been developed with the goal of shifting those with the unfortunate fat storing phenotype to a more genetically lean, fat burning phenotype.
The goal is to convince the WAT cells currently in your body, to trigger the intracellular production of brite cells, so that instead of just being fat storage depots and adipokine factories, they will also actually burn fat.
Research has shown that the hormone irisin (endogenous or exogenous), might trigger brite cell formation, as well as cold therapy, but the evidence is quite often contradictory as far as effectiveness. One of the current lines of thought is that not all white cells have this potential to turn brite, but those that do are located in specific places in humans, particularly along the spine and around the collarbone. But like BAT cells, we don't need many of them to have a big effect. And it turns out; people genetically prone to fatness are likely to express less of these cells.
BAT mitochondria respond to something called UCP1 (uncoupling protein 1) to burn fat and generate heat, while brite cells seem to express lower levels of UCP1. However, brite cells potentially burn fat independently of UCP1 signaling, and furthermore, with the proper triggers, brite fat can actually turn on high levels of UCP1 (2). Multiple ingredients in the Brite formula will encourage WAT cells to upregulate UCP1 levels.
The research shows that once developed, these brite cells directly correlate with leanness and can likely reduce metabolic disease and obesity in humans (3).
With that background in mind, the next thing we want to look at is a fatty acid called CLnA.
Conjugated Linolenic Acid (CLnA)
By now most people are well aware of conjugated linoleic acid (CLA), and while a similar fatty acid, conjugated linolenic acid (CLnA) functions quite differently. CLnA is found naturally in several seed oils, but can also be produced in small amounts endogenously by gut bacteria.
Current research has demonstrated CLnA's unique potential for fat loss from multiple angles. We have multiple sources of CLnA in the Brite formula, but first lets look at a little background on the overall CLnA research.
In a recent review published in the journal Lipids, CLnA was found to exhibit anti-obeseogenic properties, as well as reducing inflammation, boosting immune function, and improving overall cardiovascular health (4).
The worst thing a WAT cell can do is become dysfunctional, which will reduce it's ability to become a brite cell and cause it to become highly efficient at excessive fat storage and poor at releasing stored fatty acids to be oxidized. Normal cellular functioning involves low oxidative stress, low lipid peroxidation, and low inflammation, with optimal levels of superoxide dismutase (SOD). CLnA administration has been shown to support all of these (5,6).
In a study comparing CLnA to CLA, animals had a higher beta-oxidation rate and lost more fat in the CLnA group (7). Another study showed that CLnA had an apoptotic effect on proliferating pre-adipocytes (8). From a general health perspective, CLnA has also been shown to protect LDL cholesterol from oxidation (9).