EvoMuse Virile Mane Enhanced

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    When we were talking about this product a while back I thought well good something I don't need. Tonight my fiance cut my hair and thinks I'm getting a bit thin in places!
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    Thinning hair brah, checking in...so this works better than propecia/rogaine treatment?
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    Will it help me grow a beard?








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    Not until after your transformation surgery. Be free, young butterfly.
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    How many testers you looking for and do we need to submit headshots for the audition process? Ooh, my agent is quite excited.
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    YOu see this black couch over in the corner? You want the job, you know what to do.

    I will have enough of the beta (yeah, it's pretty expensive at these small quantities) for about 10 testers. I will need to see good photos of your thinning areas.
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    Cool. I'll shoot you some and you can see what you think...pm me your hotmail email?
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    Quote Originally Posted by dsade View Post
    YOu see this black couch over in the corner? You want the job, you know what to do.

    I will have enough of the beta (yeah, it's pretty expensive at these small quantities) for about 10 testers. I will need to see good photos of your thinning areas.
    Do i need to submit new photos or are ones i already submitted good to go ?
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    Quote Originally Posted by Geoforce View Post
    When we were talking about this product a while back I thought well good something I don't need. Tonight my fiance cut my hair and thinks I'm getting a bit thin in places!


    Was the last person that cut your hair an old Gypsy woman that touched your scalp and muttered "THINNER!"?
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    Quote Originally Posted by schizm View Post
    Thinning hair brah, checking in...so this works better than propecia/rogaine treatment?
    We share one pathway with Rogaine, but there is so much more to it.

    Propecia has so many systemic side effects to make it not worth it.
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    Quote Originally Posted by dollar662 View Post
    Do i need to submit new photos or are ones i already submitted good to go ?
    You're good to go.
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    matt-what do you think about a combo rosemary,jojoba, and grapeseed oil? I use them in my daily shampoo for scalp health. my shampoo has emu or id add that in too
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    Quote Originally Posted by phantom View Post
    matt-what do you think about a combo rosemary,jojoba, and grapeseed oil? I use them in my daily shampoo for scalp health. my shampoo has emu or id add that in too
    They have good antioxidant properties, and jojoba is a decent emollient.
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    Quote Originally Posted by dsade View Post
    YOu see this black couch over in the corner? You want the job, you know what to do.
    lol'd

    Quote Originally Posted by dsade View Post
    Propecia has so many systemic side effects to make it not worth it.
    Couldn't agree more. I hear horror stories about this all the time. I'd prefer to have a good head of hair and sexual health, but if I had to choose, the latter is always going to win (because I actually can pull off the shaved head well enough).
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    Quote Originally Posted by MidwestBeast View Post
    lol'd



    Couldn't agree more. I hear horror stories about this all the time. I'd prefer to have a good head of hair and sexual health, but if I had to choose, the latter is always going to win (because I actually can pull off the shaved head well enough).
    Too much propecia and you won't be pulling ANYTHING off.
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    How much propecia is to much? Several years back I used it for about a year straight..
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    When are these logs being tossed up? My damn alopecia areata monolocularis is coming back. Dat der autoimmune baldness.
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    I'm wit it. My hair line has resided and thinning.
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    Other than a couple of people I already approved, I have gotten zero pictures sent to me to pick the testers.

    This will be ready next week.
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    Quote Originally Posted by dsade View Post
    Other than a couple of people I already approved, I have gotten zero pictures sent to me to pick the testers.

    This will be ready next week.
    Check your email. Pics sent
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    Oh you're still accepting applicants? Ill send ya a pic.
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    Not sure if it qualifies, since it's not MPB, it's an autoimmune disease, but tossing my name in the hat.



    This is usually just the beginning, I wish I still had photos of it when it was really bad. Bald spots about 4 inches in diameter.
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    Still around.....waiting....lol
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    I would love to try this out.

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    Hope its not too late. But I wasn't sure how to attach pics in a pm.
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    I'll be mixing these up this week.
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    I shave my head so would that keep me out of the trial?
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    i know i just joined but ive been trying to find a solution to my hair problem & would love to try it out. Im 20, healthy, ive began to recede and thin in my temples & would like to give this a try & am willing to stick to it and do a complete log of everything. let me know and ill send you a pic of my head.
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    Any news on this?
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    Quote Originally Posted by halfhuman View Post
    Any news on this?
    Betas will be available on Tuesday. They will be $20.
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    Quote Originally Posted by domore View Post
    Betas will be available on Tuesday. They will be $20.
    Awesome! Remind us lol.
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    Thanks to the shutdown, the last ingredient I was waiting for is stuck in customs.
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    Quote Originally Posted by dsade View Post
    Thanks to the shutdown, the last ingredient I was waiting for is stuck in customs.
    Damn that sucks
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    Quote Originally Posted by halfhuman View Post
    Damn that sucks
    It's an important one, too....this is the ONLY study you are getting for now.

    Life Sci. 2012 Nov 2;91(19-20):935-43. doi: 10.1016/j.lfs.2012.09.008. Epub 2012 Sep 21.
    Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling.
    Park PJ, Moon BS, Lee SH, Kim SN, Kim AR, Kim HJ, Park WS, Choi KY, Cho EG, Lee TR.
    Source

    Bioscience Research Institute, AmorePacific Corporation R&D Center, 314-1, Bora-dong, Giheung-gu, Yongin 446-729, Republic of Korea.
    Abstract
    AIMS:

    The activation of Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis by stimulating bulge stem cells. This study was to obtain the activator of Wnt/β-catenin signaling pathway from natural products and to determine whether this activator can induce anagen hair growth in mice.
    MAIN METHODS:

    To identify materials that activate Wnt/β-catenin signaling pathway, 800 natural product extracts were screened using pTOPFlash assay and neural progenitor cell (NPC) differentiation assay. A selected extract was further tested for its effects on alkaline phosphatase (ALP) activity in human immortalized dermal papilla cell (iDPC) and the proliferation in iDPC and immortalized rat vibrissa DPC (RvDP). Finally, hair growth-promoting effects were evaluated in the dorsal skin of C57BL/6 mice.
    KEY FINDINGS:

    Aconiti Ciliare Tuber (ACT) extract was one of the most active materials in both pTOPFlash and NPC differentiation assays. It promoted the differentiation of NPC cells even under proliferation-stimulating conditions (basic fibroblast growth factor: bFGF). It also increased ALP activity and proliferation of iDPC in dose-dependent manners, and it stimulated the induction of the anagen hair growth in C57BL/6 mice. These results suggest that ACT extract activates the Wnt/β-catenin signaling pathway by enhancing β-catenin transcription and has the potential to promote the induction of hair growth via activation of the stem cell activity of the dermal papilla cells.
    SIGNIFICANCE:

    This is the first report indicating benefits of ACT extract in hair loss prevention by triggering the activation of Wnt/β-catenin signaling pathway and induction of the anagen hair growth in mice.

    Copyright © 2012 Elsevier Inc. All rights reserved.

    PMID:
    23000887
    [PubMed - indexed for MEDLINE]
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    ^^ hopefully you will see what "stem cell activation" means for this product, especially as compared to version 1.
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    Nice study and very promising. Can't wait for the release.
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    Quote Originally Posted by halfhuman View Post
    Nice study and very promising. Can't wait for the release.
    The rest of the formula only gets better.
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    Quote Originally Posted by dsade View Post
    The rest of the formula only gets better.
    I believe you. I love your products. Looking forward to it
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    Quote Originally Posted by dsade View Post
    Thanks to the shutdown, the last ingredient I was waiting for is stuck in customs.
    Damn. That's no bueno.
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    Quote Originally Posted by dsade View Post
    I have been watching the research VERY closely since the original. The original ended up being more effective at slowing/preventing loss in most users, though quite a few reports of excellent growth.

    I used the wrong TRPV1 agonist, IMO, and found a better one for the new version, as well as quite a few new angles.
    A Hot New Twist to Hair Biology
    Involvement of Vanilloid Receptor-1 (VR1/TRPV1) Signaling in Human Hair Growth Control

    Enikő Bodó, Tamás Bíró, [...], and Ralf Paus

    The vanilloid receptor-1 (VR1, or transient receptor potential vanilloid-1 receptor, TRPV1) is activated by capsaicin, the key ingredient of hot peppers. TRPV1 was originally described on sensory neurons as a central integrator of various nociceptive stimuli. However, several human skin cell populations are also now recognized to express TRPV1, but with unknown function. Exploiting the human hair follicle (HF) as a prototypic epithelial-mesenchymal interaction system, we have characterized the HF expression of TRPV1 in situ and have examined TRPV1 signaling in organ-cultured human scalp HF and outer root sheath (ORS) keratinocytes in vitro. TRPV1 immunoreactivity was confined to distinct epithelial compartments of the human HF, mainly to the ORS and hair matrix. In organ culture, TRPV1 activation by capsaicin resulted in a dose-dependent and TRPV1-specific inhibition of hair shaft elongation, suppression of proliferation, induction of apoptosis, premature HF regression (catagen), and up-regulation of intrafollicular transforming growth factor-β2. Cultured human ORS keratinocytes also expressed functional TRPV1, whose stimulation inhibited proliferation, induced apoptosis, elevated intracellular calcium concentration, up-regulated known endogenous hair growth inhibitors (interleukin-1β, transforming growth factor-β2), and down-regulated known hair growth promoters (hepatocyte growth factor, insulin-like growth factor-I, stem cell factor). These findings strongly support TRPV1 as a significant novel player in human hair growth control, underscore the physiological importance of TRPV1 in human skin beyond nociception, and identify TRPV1 as a promising, novel target for pharmacological manipulations of epithelial growth disorders.

    ----------------------------------------------------------------------------------------------------------------------------------------------------------

    TRPV1 antagonist, PAC-14028, can accelerate hair growth in vivo

    JA Seo, I-H Bae, MY Park, K-W Lee, Y-H Park and K-M Lim Medical Beauty Research Institute, AmorePacific Corporation R&D Center, Yongin, Republic of Korea

    Transient receptor potential vanilloid type 1 (TRPV1) is a cation channel activated by diverse noxious stimuli like capsaicin, low pH, or heat. TRPV1 is expressed not only in peripheral sensory nerve fibers (C and Aδ) but also in the skin epidermal cells, including hair follicle. Recently, it was revealed that TRPV1 might be associated with hair growth control. Here we aimed to investigate if the blockade of TRPV1 might affect hair growth, by employing a new TRPV1 antagonist, PAC-14028. The effect of PAC-14028 on hair growth was evaluated in vivo using an anagen induction and a catagen induction model in C57BL/6 mice. In macroscopic evaluation, PAC-14028 accelerated the onset of anagen hair cycle (14 days after treatment) compared to vehicle (27–28 days after treatment). Mice treated with 1% PAC-14028 showed significantly increased hair weight in a dose-dependent manner (101.25±16.51 and 56.81±10.58 mg for PAC-14028 1% and vehicle control, respectively). In the catagen induction model, the 1% PAC-14028-treated group showed darker skin as determined by a skin chromameter, which was comparable to 2% minoxidil. In addition, 1% PAC-14028 increased the skin thickness, confirming the delay of catagen induction. These results demonstrate that TRPV1 antagonist could be useful for hair growth based on anagen elongation and induction in vivo.
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    I already covered TRPV1 activation in the original formula. The problem is that you can over or under activate it.

    in the new version we hit that perfect balance.
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