SPP Presents: SLINtensity

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  1. Note that the action indicated is primarily in L6 myotubes and is NOT insulin dependent.

    Eur J Nutr. 2012 May 19. [Epub ahead of print]
    4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway.

    Jaiswal N, Maurya CK, Venkateswarlu K, Sukanya P, Srivastava AK, Narender T, Tamrakar AK.
    Source

    Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow, 226001, India.

    Abstract

    PURPOSE:

    To determine the effect of 4-Hydroxyisoleucine (4-HIL), an unusual amino acid isolated from the seeds of Trigonella foenum-graecum, on glucose uptake and the translocation of glucose transporter 4 (GLUT4) to plasma membrane in skeletal muscle cells and to investigate the underlying mechanisms of action.
    METHODS:

    Rat skeletal muscle cells (L6-GLUT4myc) were treated with 4-HIL, and the effect on glucose uptake was determined by measuring the incorporation of radio-labeled 2-deoxy-[(3)H]-D: -glucose (2-DG) into the cell. Translocation of GLUT4myc to plasma membrane was measured by an antibody-coupled colorimetric assay.
    RESULTS:

    The prolonged exposure (16 h) of L6-GLUT4myc myotubes to 4-HIL caused a substantial increase in the 2-DG uptake and GLUT4 translocation to the cell surface, without changing the total amount of GLUT4 and GLUT1. Cycloheximide treatment reversed the effect of 4-HIL on GLUT4 translocation to the basal level suggesting the requirement of new protein synthesis. The 4-HIL-induced increase in GLUT4 translocation was completely abolished by wortmannin, and 4-HIL significantly increased the basal phosphorylation of AKT (Ser-473), but did not change the mRNA expression of AKT, IRS-1, GLUT4, and GSK3β.
    CONCLUSION:

    Results suggest that 4-HIL stimulates glucose uptake in L6-GLUT4myc myotubes by enhancing translocation of GLUT4 to the cell surface in a PI-3-kinase/AKT-dependent mechanism.

    PMID:22610671 [PubMed - as supplied by publisher]
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  2. in for updates.
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  3. This looks extremely interesting .

  4. Products that make other products work even better. Matt is an evil genius.
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    PM me with any questions!

  5. Can you say SYNERGY!!
    Always open light. Itís not what you open with, itís what you finish with. Louie Simmons
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  6. Slintensity experiment 1 was a huge success, in a way. I actually have to dial DOWN the dosage of the 4-OH. Big carb meal and went from zero to hypo in 45 minutes.

    Vascularity - blown, and muscle fullness is obscene, even this morning.
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  7. Quote Originally Posted by dsade View Post
    Slintensity experiment 1 was a huge success, in a way. I actually have to dial DOWN the dosage of the 4-OH. Big carb meal and went from zero to hypo in 45 minutes.

    Vascularity - blown, and muscle fullness is obscene, even this morning.
    You must spread some Reputation around before giving it to dsade again.

  8. One lucky guinea pig!! Lol
    Always open light. Itís not what you open with, itís what you finish with. Louie Simmons

  9. Nice , Looking forward to this

  10. I'm shooting for a price point under $25.
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  11. Quote Originally Posted by dsade View Post
    I'm shooting for a price point under $25.

    Damn thats a great price for what this product has in it ! Comparing the price point and product profile to others you surely have another winner on your hands

  12. Quote Originally Posted by dsade View Post
    I'm shooting for a price point under $25.
    o boy!

  13. Quote Originally Posted by dsade View Post
    I'm shooting for a price point under $25.
    The most effective and the most affordable?
    EvoMuse Products Rep

    PM me with any questions!

  14. Quote Originally Posted by dsade
    Slintensity experiment 1 was a huge success, in a way. I actually have to dial DOWN the dosage of the 4-OH. Big carb meal and went from zero to hypo in 45 minutes.

    Vascularity - blown, and muscle fullness is obscene, even this morning.
    Oh man the teasers never stop excited for this to come out.
  15. AnabolicMinds Site Rep
    MidwestBeast's Avatar

    Quote Originally Posted by PrepNwa23 View Post
    Oh man my erections never stop excited for this to come out.
    Down, boy!
    Psalm 34:10 - "The lions may grow weak and hungry, but those who seek the Lord lack no good thing."
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  16. Slintensity: good for the wang?

  17. Quote Originally Posted by Bolanrox View Post
    Slintensity: good for the wang?
    If your erection lasts more than 4 hours find more women.
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  18. Any release time frame?
    Always open light. Itís not what you open with, itís what you finish with. Louie Simmons
  19. AnabolicMinds Site Rep
    MidwestBeast's Avatar

    Quote Originally Posted by AZMIDLYF View Post
    Any release time frame?
    I don't know if Matt has that, yet, but I do know he's setting stuff up for some more beta testing right now. I'm pretty amped based on his observations.
    Psalm 34:10 - "The lions may grow weak and hungry, but those who seek the Lord lack no good thing."
    EvoMuse Representative | [email protected] | Inspire to Evolve

  20. I need his Mormodica source. Lol
    Always open light. Itís not what you open with, itís what you finish with. Louie Simmons

  21. Quote Originally Posted by MidwestBeast View Post
    I don't know if Matt has that, yet, but I do know he's setting stuff up for some more beta testing right now. I'm pretty amped based on his observations.
    Shhh....this round of beta testers is only for Facebook fans that participate.

    I have the dosages dialed in, just need to get the caps ready to go out.
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  22. Quote Originally Posted by dsade
    Shhh....this round of beta testers is only for Facebook fans that participate.

    I have the dosages dialed in, just need to get the caps ready to go out.
    Anxiously waiting.

  23. So momordica and 4-oh-isl. Looks very similar to something I was playing around with

    Though it totally blows my mind that you managed to source an 80% extract

  24. Quote Originally Posted by mr.cooper69 View Post
    So momordica and 4-oh-isl. Looks very similar to something I was playing around with

    Though it totally blows my mind that you managed to source an 80% extract
    I was pushing and pushing for a pure synthetic, but with the FDA being dickish lately I jumped at this. The price is steep, but the material I am playing with is incredibly potent! I'm actually ending up using less that I initially estimated.

    SHould have some caps out for beta testing end of this week or early next week.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  25. Quote Originally Posted by dsade View Post
    I was pushing and pushing for a pure synthetic, but with the FDA being dickish lately I jumped at this. The price is steep, but the material I am playing with is incredibly potent! I'm actually ending up using less that I initially estimated.

    SHould have some caps out for beta testing end of this week or early next week.

    This just sounds better and better.
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