SPP Presents: Abliderate Advanced

[Geoforce]

Had my first application today after exfoliating with Java soap. I didnt feel any burning, I would call it more of a warming sensation. After about 5 minutes, wow did I feel my mid-section start tightening up. It was a pretty awesome feeling. Looking forward to continuing use and seeing the results. 2 bottles worth.

You shouldn't see any burn with Abliderate Advanced. The capsaicin is responsible for the burn in Eviscerate/Smolder and it isn't in Abliderate Advanced. Keep us updated on your results though, I simply love the product!

[dsade]

• Marie-Noëlle Dieudonné, Anes Sammari, Esther Dos Santos, Marie-Christine Leneveu, Yves Giudicelli, René Pecquery
• Erratum to “Sex steroids and leptin regulate 11β-hydroxysteroid dehydrogenase I and P450 aromatase expressions in human preadipocytes: Sex specificities” [J. Steroid Biochem. Mol. Biol. 99 (4–5) (2006) 189–196]
• The Journal of Steroid Biochemistry and Molecular Biology, Volume 101, Issue 1, September 2006, Page 85
• PDF (60 K)

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Abstract

Adipose tissue is an important site of steroid hormone biosynthesis, as type I 11β-hydroxysteroid dehydrogenase (HSD1), the enzyme responsible for the conversion of cortisone into cortisol and the P450 aromatase, the enzyme catalysing androgens aromatization into estrogens, are both expressed in human adipose tissue. In the present report, we have investigated the possibility that sex steroids and leptin could regulate these two enzymes in cultured preadipocytes from men and women intra-abdominalfat depots.
In women preadipocytes, human recombinant leptin down-regulates HSD1 mRNA expression (−58%) and P450 aromatase activity (−26%). Conversely, leptin up-regulates the HSD1 (2.4-fold) and the P450 aromatase (1.6-fold) mRNA expression in men preadipocytes. In women preadipocytes, 17β-estradiol strongly stimulates HSD1 mRNA expression (10-fold) and, in contrast, decreases by half the P450 aromataseexpression. In men, 17β-estradiol has no influence on HSD1 expression but up-regulates P450 aromatase mRNA expression (2.4-fold). Finally, androgens increase by a factor of 2.5–5 the mRNA expression of both enzymes in men.
These findings suggest that sex steroids and leptin either increase or decrease local cortisol and estrogens productions in men or in women preadipocytes, respectively. They also indicate that steroid metabolism in adipose tissue is controlled by a coordinated regulation of P450 aromatase and HSD1 expressions. Finally, the important sex-specific differences described herein may also contribute to explain the sexual dimorphism of body fat distribution in humans.

[dsade]

• Marie-Noëlle Dieudonné, Anes Sammari, Esther Dos Santos, Marie-Christine Leneveu, Yves Giudicelli, René Pecquery
• Erratum to “Sex steroids and leptin regulate 11β-hydroxysteroid dehydrogenase I and P450 aromatase expressions in human preadipocytes: Sex specificities” [J. Steroid Biochem. Mol. Biol. 99 (4–5) (2006) 189–196]
• The Journal of Steroid Biochemistry and Molecular Biology, Volume 101, Issue 1, September 2006, Page 85
• PDF (60 K)

---

Abstract

Adipose tissue is an important site of steroid hormone biosynthesis, as type I 11β-hydroxysteroid dehydrogenase (HSD1), the enzyme responsible for the conversion of cortisone into cortisol and the P450 aromatase, the enzyme catalysing androgens aromatization into estrogens, are both expressed in human adipose tissue. In the present report, we have investigated the possibility that sex steroids and leptin could regulate these two enzymes in cultured preadipocytes from men and women intra-abdominalfat depots.
In women preadipocytes, human recombinant leptin down-regulates HSD1 mRNA expression (−58%) and P450 aromatase activity (−26%). Conversely, leptin up-regulates the HSD1 (2.4-fold) and the P450 aromatase (1.6-fold) mRNA expression in men preadipocytes. In women preadipocytes, 17β-estradiol strongly stimulates HSD1 mRNA expression (10-fold) and, in contrast, decreases by half the P450 aromataseexpression. In men, 17β-estradiol has no influence on HSD1 expression but up-regulates P450 aromatase mRNA expression (2.4-fold). Finally, androgens increase by a factor of 2.5–5 the mRNA expression of both enzymes in men.
These findings suggest that sex steroids and leptin either increase or decrease local cortisol and estrogens productions in men or in women preadipocytes, respectively. They also indicate that steroid metabolism in adipose tissue is controlled by a coordinated regulation of P450 aromatase and HSD1 expressions. Finally, the important sex-specific differences described herein may also contribute to explain the sexual dimorphism of body fat distribution in humans.

[Geoforce]

Back in stock at the Planet!!!

[dsade]

Just a note: VERY limited stock. Our bottle error has not been rectified yet, in spite of a ton of calls. They have less than 30 bottles to work with.

[Geoforce]

Once again, AA is back at the Planet and no longer sold out.

[MidwestBeast]

Once again, AA is back at the Planet and no longer sold out.

Hooray!

[jwa254]

Just came in to profess my love of AA. I got my first bottle the first week in August and it's still not quite empty! My second bottle is stashed in my cabinet.

[Geoforce]

Just came in to profess my love of AA. I got my first bottle the first week in August and it's still not quite empty! My second bottle is stashed in my cabinet.

Results? It is probably my favorite product of our line.

[MidwestBeast]

Just came in to profess my love of AA. I got my first bottle the first week in August and it's still not quite empty! My second bottle is stashed in my cabinet.

Very cool, bro!