GDA Q and A

Page 2 of 2 First 12

  1. Any more GDA questions?

    I'll post up a Pre cheat meal plan for optimal nutrient partioning and fat attenuation tomorrow

    It'll help with food digestion as well


  2. Quote Originally Posted by EBF Inc
    Any more GDA questions?

    I'll post up a Pre cheat meal plan for optimal nutrient partioning and fat attenuation tomorrow

    It'll help with food digestion as well
    Some people including myself may want to know the timing dosage of a NP/GDA pre cardio for optimal uptake and increased PPAR agonism and AMPk for endurance and fat burning effects...
    ...::: Olympus Labs Athlete & Representative :::...
    Crossfit - DEMIGOD -
    •   
       


  3. that happens in about 30 minutes.

    so 30 minutes pre cardio will do the trick.

  4. Will BCAAs intra before the NP and cardio negate it?

    Should one just consume 10g leucine pre weights, halfway through, take say 1 recompadrol (or any NP for others who use say slin sane) 30mins pre cardio?
    ...::: Olympus Labs Athlete & Representative :::...
    Crossfit - DEMIGOD -

  5. Quote Originally Posted by runner_79 View Post
    Will BCAAs intra before the NP and cardio negate it?

    Should one just consume 10g leucine pre weights, halfway through, take say 1 recompadrol (or any NP for others who use say slin sane) 30mins pre cardio?
    If you're 450lbs of LBM, feel free to consume 10g leucine



    Thoughts on this: http://diabetes.diabetesjournals.org...59/8/1879.long

    Notice that the "normal" mice also suffered from significant muscle catabolism.

    CONCLUSIONS:

    Berberine impairs muscle metabolism by two novel mechanisms. It impairs mitochonidrial function stimulating the expression of atrogin-1 without affecting phosphorylation of forkhead transcription factors. The increase in atrogin-1 not only stimulated protein degradation but also suppressed protein synthesis, causing muscle atrophy
    •   
       


  6. Quote Originally Posted by mr.cooper69

    If you're 450lbs of LBM, feel free to consume 10g leucine

    Thoughts on this: http://diabetes.diabetesjournals.org...59/8/1879.long

    Notice that the "normal" mice also suffered from significant muscle catabolism.

    CONCLUSIONS:

    Berberine impairs muscle metabolism by two novel mechanisms. It impairs mitochonidrial function stimulating the expression of atrogin-1 without affecting phosphorylation of forkhead transcription factors. The increase in atrogin-1 not only stimulated protein degradation but also suppressed protein synthesis, causing muscle atrophy
    Oh noes!!
    I'm not 450 lbs of lbm... I do consume a lot of bcaas though.
    Somedays I get 50g of it.

    Interesting on the berberine. Makes you smaller. Man....
    RecoverBro ELITE

  7. Quote Originally Posted by mr.cooper69

    If you're 450lbs of LBM, feel free to consume 10g leucine

    Thoughts on this: http://diabetes.diabetesjournals.org...59/8/1879.long

    Notice that the "normal" mice also suffered from significant muscle catabolism.

    CONCLUSIONS:

    Berberine impairs muscle metabolism by two novel mechanisms. It impairs mitochonidrial function stimulating the expression of atrogin-1 without affecting phosphorylation of forkhead transcription factors. The increase in atrogin-1 not only stimulated protein degradation but also suppressed protein synthesis, causing muscle atrophy
    Hmmmmm
    ...::: Olympus Labs Athlete & Representative :::...
    Crossfit - DEMIGOD -

  8. Quote Originally Posted by EBF Inc View Post
    Please post any question relating to ANY GDA you may have questions about, whether an EBF product or not. Knowledge it power.


    Lets begin....
    As for berberine, wouldnt it's effects on inhibiting protein synthesis and increasing protein degradation be detrimental to a bluking/lean mass gain plan?

  9. @uva,

    Things like this are relative.

    you see, ALA increases AMPk as well which reduces mTOR. Whats important is to supplement with additional leucine to kind of counteract that from happening. The body is all give and take, it works on checks and balances. Weight loss, and lifting in essence are catabolic, we need to fine tune our bodies to increase specific pathways favorable to our goals.

    If there is something specific to berberine im missing here, please let me know.

  10. Quote Originally Posted by EBF Inc View Post
    @uva,

    Things like this are relative.

    you see, ALA increases AMPk as well which reduces mTOR. Whats important is to supplement with additional leucine to kind of counteract that from happening. The body is all give and take, it works on checks and balances. Weight loss, and lifting in essence are catabolic, we need to fine tune our bodies to increase specific pathways favorable to our goals.

    If there is something specific to berberine im missing here, please let me know.
    I fully agree with the give and take. Downregulation of one pathway often means up-regulation of another. However, could you address the study I posted, as berberine's net effect seems to be muscle catabolism. I post this merely because berberine has a ton of effects that interest me (moreso for general health than activity in the gut).

  11. sorry coop my comps not letting me qoute things.

    as far as the atrogin.... i believe USP labs went over this in great detail heres the qoute

    MulletSoldier replied with this:

    "Great question!

    I unfortunately do not have access to this full journal, so my commentary will be mostly speculative at this time. This being said, I will address the comments as best as possible.

    As we see from the abstract, it appears that berberine extract-induced decreased muscle protein synthesis and increased muscle protein degradation is dependent on an increased expression of both atrogin-1, a key proteolytic gene present in a variety of catabolic states, and eIF3-f, a key component of the mTOR activation pathway. At first blush, this obviously appears to be indefensibly negative, as the atrogin-1 induction was not dependent upon the Atk/PI3K transcription pathway, and is thus entirely the result of berberine.

    With that being said, we need to remember an important fact: these were diabetic mice. Insulin resistance is often associated with an increased in the activity of the ubiquitin-proteasome proteolytic pathway, and in particular, the expression of atrogin-1 to promote muscle atrophy. The mechanisms here are complex, but for a reference, the expression of both atrogin-1 and atrogin-1 transcription promoters have been shown to be increased by 15 fold in insulin resistant states."

  12. what i seem to find stranger is that Berberine inhibits Fox-O1 which suppresses gluconeogenic hormones,

    there needs to be human studies. However, i think that due to our diets, slight inhibition wont and shouldnt be worrysome

  13. One more thing i have to comment on...

    Diabetics have increased expression of a lot more genes than we do. I dont think that atrogin levels in normal, non diabetic humans play a role in this.

    Id like to see how other things like ALA, due to increases in AMPk, affect atrogin and muscle protein synthesis. We alreaqdy do know that it affect mTOR.

    I will indeed look into this further, and coop, if you can as well on the Atrogin-1 levels of normal vs diabetic humans. Im sure we can collectively come up with an answer

  14. Quote Originally Posted by EBF Inc View Post
    sorry coop my comps not letting me qoute things.

    as far as the atrogin.... i believe USP labs went over this in great detail heres the qoute

    MulletSoldier replied with this:

    "Great question!

    I unfortunately do not have access to this full journal, so my commentary will be mostly speculative at this time. This being said, I will address the comments as best as possible.

    As we see from the abstract, it appears that berberine extract-induced decreased muscle protein synthesis and increased muscle protein degradation is dependent on an increased expression of both atrogin-1, a key proteolytic gene present in a variety of catabolic states, and eIF3-f, a key component of the mTOR activation pathway. At first blush, this obviously appears to be indefensibly negative, as the atrogin-1 induction was not dependent upon the Atk/PI3K transcription pathway, and is thus entirely the result of berberine.

    With that being said, we need to remember an important fact: these were diabetic mice. Insulin resistance is often associated with an increased in the activity of the ubiquitin-proteasome proteolytic pathway, and in particular, the expression of atrogin-1 to promote muscle atrophy. The mechanisms here are complex, but for a reference, the expression of both atrogin-1 and atrogin-1 transcription promoters have been shown to be increased by 15 fold in insulin resistant states."
    No problem man, thanks for the response.

    Unfortunately, this quote is inaccurate because non-diabetic mice also experienced muscle catabolism. Atrogin-1 expression was not the culprit.

    I've been looking into it as well because berberine holds a lot of promise as a multi-dimensional ingredient, but it's tough to start using it when this particular study is in direct conflict with the goals of a bodybuilder.

  15. completely agree! however you need to look at it as its effects on mTOR, PGC-1a, and AMPk

    These are down regulated with an antagonism of PPARy. This is conducive to weight loss. Its very near impossible in a catabolic state to keep mTOR up, this is due to the effects Akt has on adipogenesis and glucogenesis, and protein synthesis

  16. What is the best ingredient (berberine, banaba, vandyl sulfate, ALA, gymnea, etc) for keeping blood sugar level while eating higher GI carbs?

    I eat white rice and red potatoes as my stachy carbs (cant stand brown rice or plain oatmeal) so what can I take to prevent my blood sugar from spiking?

  17. I'm curious how people feel about high GI vs. Low GI because most people feel different based on the type of carbs they eat. Ultimately I think it would only be an issue if you were diabetic or had a lethargic feeing after a certain type of carb.

    I posted this in another thread figured I'd post here.

    Is my thought process correct or am I off with the above posting/statement?
    Hardcore Purus Labs {Rep}
    Lift the fücking weight from the floor, or leave it on the ground. The thoughts are supposed to be daunting. The pain is meant to be tormenting.

  18. Quote Originally Posted by RawStrength
    What is the best ingredient (berberine, banaba, vandyl sulfate, ALA, gymnea, etc) for keeping blood sugar level while eating higher GI carbs?

    I eat white rice and red potatoes as my stachy carbs (cant stand brown rice or plain oatmeal) so what can I take to prevent my blood sugar from spiking?
    Any product if legitimate in this catagorie would do

    You can go simple and use ala or more complex and use recompadrol or any other products

  19. Quote Originally Posted by AaronJP1
    I'm curious how people feel about high GI vs. Low GI because most people feel different based on the type of carbs they eat. Ultimately I think it would only be an issue if you were diabetic or had a lethargic feeing after a certain type of carb.

    I posted this in another thread figured I'd post here.

    Is my thought process correct or am I off with the above posting/statement?
    Type ones can usually eat what they want

    Type 2 diabetics have more underlying issues like resistance in the liver in which insulin cannot block FOX01. This means the bodies liver will continue to relate glucose

    I personally feel high gi. Insulin levels spike and return to normal faster allowing increased fat burning potential.

    It can be argued the other way as well

    30g carbs equals 30g carbs. Your body will secrete the same amount of Insulin to carry that load just over different periods of time

  20. Quote Originally Posted by EBF Inc

    Type ones can usually eat what they want

    Type 2 diabetics have more underlying issues like resistance in the liver in which insulin cannot block FOX01. This means the bodies liver will continue to relate glucose

    I personally feel high gi. Insulin levels spike and return to normal faster allowing increased fat burning potential.

    It can be argued the other way as well

    30g carbs equals 30g carbs. Your body will secrete the same amount of Insulin to carry that load just over different periods of time
    Yeah so, only a diabetic should be worried about GI index...?
    Hardcore Purus Labs {Rep}
    Lift the fücking weight from the floor, or leave it on the ground. The thoughts are supposed to be daunting. The pain is meant to be tormenting.

  21. Quote Originally Posted by EBF Inc View Post
    Any product if legitimate in this catagorie would do

    You can go simple and use ala or more complex and use recompadrol or any other products
    I thought ALA spiked insulin?

    Isnt it an insulin mimetic?

  22. Quote Originally Posted by AaronJP1

    Yeah so, only a diabetic should be worried about GI index...?
    You can look at it that way, but wit the ingestion of simple carbs, we see spikes and drops in B/Sugar levels.
    Longer chains of carbs as we all know generate longer satiety and more energy over longer period. Why spike, get hyper for say 2 hours, then fall off the face of the earth with no energy and going hypo?
    ...::: Olympus Labs Athlete & Representative :::...
    Crossfit - DEMIGOD -

  23. Quote Originally Posted by AaronJP1

    Yeah so, only a diabetic should be worried about GI index...?
    Yes and no. Depends on the type of diabetic and medication used.

  24. Quote Originally Posted by RawStrength

    I thought ALA spiked insulin?

    Isnt it an insulin mimetic?
    It increases ampk and thus activates glucose uptake therefore lowering sugars

  25. The king of GDAs will be back shortly. Should be done Monday then off for testing

  26. Quote Originally Posted by EBF Inc View Post
    The king of GDAs will be back shortly. Should be done Monday then off for testing
    New awesome label, same fantastic product, the king's back!

    (some people were waiting for it.. like everybody? lol)
    ..:: ENHANCED BODY FORMULATIONS ::..
    Recompadrol & AAV2 - PM me with any questions

  •   

      
     

Log in
Log in