Ursobolic and Magnesium

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    Ursobolic and Magnesium


    Magnesium and anabolic hormones in older men. [Int J Androl. 2011] - PubMed - NCBI

    Magnesium and anabolic hormones in older men.

    Maggio M, Ceda GP, Lauretani F, Cattabiani C, Avantaggiato E, Morganti S, Ablondi F, Bandinelli S, Dominguez LJ, Barbagallo M, Paolisso G, Semba RD, Ferrucci L.
    Source

    Section of Geriatrics, Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy Geriatric Rehabilitation Department, University Hospital of Parma, Parma, Italy Geriatric Unit, Azienda Sanitaria Firenze, Florence, Italy Geriatric Unit, Department of Internal Medicine and Emergent Pathologies, University of Palermo, Palermo, Italy Department of Geriatric Medicine and Metabolic Diseases, VI Unit of Internal Medicine, Second University of Naples, Naples, Italy Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging Intramural Research Program (NIA-IRP), National Institutes of Health (NIH), Baltimore, Maryland, USA.

    Abstract

    Optimal nutritional and hormonal statuses are determinants of successful ageing. The age associated decline in anabolic hormones such as testosterone and insulin-like growth factor 1 (IGF-1) is a strong predictor of metabolic syndrome, diabetes and mortality in older men. Studies have shown that magnesium intake affects the secretion of total IGF-1 and increase testosterone bioactivity. This observation suggests that magnesium can be a modulator of the anabolic/catabolic equilibrium disrupted in the elderly people. However, the relationship between magnesium and anabolic hormones in men has not been investigated. We evaluated 399 ≥65-year-old men of CHIANTI in a study population representative of two municipalities of Tuscany (Italy) with complete data on testosterone, total IGF-1, sex hormone binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEAS) and serum magnesium levels. Linear regression models were used to test the relationship between magnesium and testosterone and IGF-1. Mean age of the population was 74.18  6.43 (years  SD, age range 65.2-92.4). After adjusting for age, magnesium was positively associated with total testosterone (β  SE, 34.9  10.3; p = 0.001) and with total IGF-1 (β  SE, 15.9  4.8; p = 0.001). After further adjustment for body mass index (BMI), log (IL-6), log (DHEAS), log (SHBG), log (insulin), total IGF-1, grip strength, Parkinson's disease and chronic heart failure, the relationship between magnesium and total testosterone remained strong and highly significant (β  SE, 48.72  12.61; p = 0.001). In the multivariate analysis adjusted for age, BMI, log (IL-6), liver function, energy intake, log (insulin), log (DHEAS), selenium, magnesium levels were also still significantly associated with IGF-1 (β  SE, 16.43  4.90; p = 0.001) and remained significant after adjusting for total testosterone (β  SE, 14.4  4.9; p = 0.01). In a cohort of older men, magnesium levels are strongly and independently associated with the anabolic hormones testosterone and IGF-1.
    2011 The Authors. International Journal of Andrology 2011 European Academy of Andrology

    Do you recommend increasing Magnesium (say, Citrate or Glycinate) intake while on Ursobolic for enhanced effect?

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    Quote Originally Posted by dsade View Post
    Magnesium and anabolic hormones in older men. [Int J Androl. 2011] - PubMed - NCBI

    Magnesium and anabolic hormones in older men.

    Maggio M, Ceda GP, Lauretani F, Cattabiani C, Avantaggiato E, Morganti S, Ablondi F, Bandinelli S, Dominguez LJ, Barbagallo M, Paolisso G, Semba RD, Ferrucci L.
    Source

    Section of Geriatrics, Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy Geriatric Rehabilitation Department, University Hospital of Parma, Parma, Italy Geriatric Unit, Azienda Sanitaria Firenze, Florence, Italy Geriatric Unit, Department of Internal Medicine and Emergent Pathologies, University of Palermo, Palermo, Italy Department of Geriatric Medicine and Metabolic Diseases, VI Unit of Internal Medicine, Second University of Naples, Naples, Italy Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging Intramural Research Program (NIA-IRP), National Institutes of Health (NIH), Baltimore, Maryland, USA.

    Abstract

    Optimal nutritional and hormonal statuses are determinants of successful ageing. The age associated decline in anabolic hormones such as testosterone and insulin-like growth factor 1 (IGF-1) is a strong predictor of metabolic syndrome, diabetes and mortality in older men. Studies have shown that magnesium intake affects the secretion of total IGF-1 and increase testosterone bioactivity. This observation suggests that magnesium can be a modulator of the anabolic/catabolic equilibrium disrupted in the elderly people. However, the relationship between magnesium and anabolic hormones in men has not been investigated. We evaluated 399 ≥65-year-old men of CHIANTI in a study population representative of two municipalities of Tuscany (Italy) with complete data on testosterone, total IGF-1, sex hormone binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEAS) and serum magnesium levels. Linear regression models were used to test the relationship between magnesium and testosterone and IGF-1. Mean age of the population was 74.18  6.43 (years  SD, age range 65.2-92.4). After adjusting for age, magnesium was positively associated with total testosterone (β  SE, 34.9  10.3; p = 0.001) and with total IGF-1 (β  SE, 15.9  4.8; p = 0.001). After further adjustment for body mass index (BMI), log (IL-6), log (DHEAS), log (SHBG), log (insulin), total IGF-1, grip strength, Parkinson's disease and chronic heart failure, the relationship between magnesium and total testosterone remained strong and highly significant (β  SE, 48.72  12.61; p = 0.001). In the multivariate analysis adjusted for age, BMI, log (IL-6), liver function, energy intake, log (insulin), log (DHEAS), selenium, magnesium levels were also still significantly associated with IGF-1 (β  SE, 16.43  4.90; p = 0.001) and remained significant after adjusting for total testosterone (β  SE, 14.4  4.9; p = 0.01). In a cohort of older men, magnesium levels are strongly and independently associated with the anabolic hormones testosterone and IGF-1.
    2011 The Authors. International Journal of Andrology 2011 European Academy of Andrology

    Do you recommend increasing Magnesium (say, Citrate or Glycinate) intake while on Ursobolic for enhanced effect?

    I recommend people get adequate intake of magnesium no matter what
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    Is 710mg magnesium daily too much? I just added sns mcc to my supplements and it puts me at 710. Was supplementing 350.. I'm thinking it is too much.. Just wanted other opinions. It would ve this amount for about 70 days.. Until I cycle off mcc
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    Quote Originally Posted by chedapalooza View Post
    Is 710mg magnesium daily too much? I just added sns mcc to my supplements and it puts me at 710. Was supplementing 350.. I'm thinking it is too much.. Just wanted other opinions
    Which form of Magnesium?

    I can go higher with Gluconate, but Citrate is too strong of a laxative for me. Oxide is a waste.
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    Quote Originally Posted by dsade View Post
    Which form of Magnesium?

    I can go higher with Gluconate, but Citrate is too strong of a laxative for me. Oxide is a waste.
    100 comes from oxide in my multi
    250 comes from oxide/gluc blend in a calcium/mag suppelement
    The rest from sns MCC which does not provide a form on the label.
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    Quote Originally Posted by chedapalooza View Post
    100 comes from oxide in my multi
    250 comes from oxide/gluc blend in a calcium/mag suppelement
    The rest from sns MCC which does not provide a form on the label.
    You can literally discount the Oxide towards your daily total. And try to get one separate from the Calcium.
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    Quote Originally Posted by dsade View Post
    You can literally discount the Oxide towards your daily total. And try to get one separate from the Calcium.
    Alright sounds good bc the calc/mag is essentially empty. So 5-600 isn't too much.. Especially for very active ppl?
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    I shoot for 750 of gluconate.
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    Magnesium Taurate is another good one.
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    They did not have gluconate. They had taurate but it was 125mg only..... I got this..



    Name:  image-2347804127.jpg
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    They also had this At stop n shop... Idk if it's any good


    Name:  image-2271633257.jpg
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    Quote Originally Posted by chedapalooza View Post
    They did not have gluconate. They had taurate but it was 125mg only..... I got this..

    <img src="http://anabolicminds.com/forum/attachment.php?attachmentid=73 133"/>

    They also had this At stop n shop... Idk if it's any good

    <img src="http://anabolicminds.com/forum/attachment.php?attachmentid=73 134"/>
    Bump
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    Quote Originally Posted by chedapalooza View Post
    Bump
    I would still try to find a pure Gluconate product.
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    Quote Originally Posted by dsade View Post
    I would still try to find a pure Gluconate product.
    They only had powdered, which Wont work for daily use if I'm at work or out to dinner, etc
    "no failure is final, nor is any success"
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    Quote Originally Posted by chedapalooza View Post
    They only had powdered, which Wont work for daily use if I'm at work or out to dinner, etc
    I picked up the Vitamin Shoppe brand, but I will tell you man, these pills are gigantic.
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    Quote Originally Posted by dsade View Post
    I picked up the Vitamin Shoppe brand, but I will tell you man, these pills are gigantic.
    I wnt there n they didn't have pure gluconate.. Idc about pill size at all lol

    Wtf, I want them lol
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    If the vitamin shop you go to carries Jarrow products get their magnesium optimizer.
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