Well I have a couple of small knots beneath my right nipple. It's gyno. I had the same problem with my left nipple and had it surgically removed a couple of years ago. I actually don't mind these knots and if I knew then what I know now, I would not have had the surgery. These two remaining knots let me know rather quickly if my hormones are out of balance. I find that if I use a good AI they are virtually non-existent. I can still feel them but they are not pronounced nor do they hurt. Moreover, as I lower my overall estrogen I seem to lean out rather quickly. I3C is a good product with solid research behind it and very inexpensive. I also like formestane for the same reason. I am currently using Formadrol by LG with good success. I don't know about pzole. It may be a good product but it's new, at least to me, and unproven. The initial study looks encouraging but only time will tell. As with most herbs the quality of extraction is critical. Moreover there is no standardization for Brassaiopsis glumerulata. At least none of which I am aware, so you are at the mercy of the supplement company. DS is a reputable company and typically puts out quality products so I would imagine that the product will prove to be effective over the long haul.