What is Triazole™?

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    I might buy a bottle of this for part of my superdrol PCT

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    Quote Originally Posted by Sldge View Post
    He started out with just Triazole and is adding in ACTX after 2 weeks. But Triazole alone would have been enough and it is definitely enough for 10mgs of SD. Which IMO is the best dose for SD.
    Good advice.

    10, 20mg max.

    I never understood why no one would put out a 5mg Superdrol product.

    Im really interested in this new Triazole!
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    Quote Originally Posted by Sldge View Post
    I think Triazole is going to work really well with DAA. I cant remember what is in Dermacrine but at least with ACTX, Triazole and DAA you are boosting test and lowering estrogen through all different pathways. I think thats a big deal, less redundancy.
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    How is coming off Triazole?
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    Will def run this with ActX. Test Factor by MN has also peeked my interest-what do you thnk of TestFactor/Triazole stack?
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    what the ingredianet?
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    Quote Originally Posted by thesinner View Post
    How is coming off Triazole?
    All alpha testers had no complaints and everything returned to normal within the week.
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    Quote Originally Posted by phantom View Post
    Will def run this with ActX. Test Factor by MN has also peeked my interest-what do you thnk of TestFactor/Triazole stack?
    Right now all that we know about Test Factor is what we have read. I haven't seen any reviews or feedback yet, and neither has Matt that i'm aware. We'll be able to give a better opinion on this as more feedback for TF comes in.
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    Quote Originally Posted by Jasen View Post
    what the ingredianet?
    Check back today for the first ingredient we will reveal.
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    Quote Originally Posted by Sldge View Post
    I think Triazole is going to work really well with DAA. I cant remember what is in Dermacrine but at least with ACTX, Triazole and DAA you are boosting test and lowering estrogen through all different pathways. I think thats a big deal, less redundancy.
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    Quote Originally Posted by JBerto View Post
    x2
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    Anyone wanting to follow along with a Triazole journal that is already into its second week can find it here: http://blog.bodybuilding.com/bigTtK

    So far the results are exciting!
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    Triazole™ introduces a BRAND NEW compound to the industry that we call pZole™. pZole™ is a NATURAL aromatase inhibitor (AI) found in the shrub Brassaiopsis glomerulata. This shrub is native to South Asia where it is used to treat rheumatism and back pain. Brassaiopsis glomerulata has been shown to contain several natural AI, of which, pZole™ has been shown to be the strongest. In fact, during a comparison study with the prescription drug Letrozole (a potent AI) there was no statistical difference between it and pZole™ with regards to aromatase inhibition!

    Aromatase is the enzyme that converts androgens like testosterone into estrogens and is the main way by which males generate estrogen. When aromatase is inhibited, your brain will detect lower levels of estrogen and will in turn respond by increasing testosterone levels significantly. In case you didn’t know, this is a good thing. Actually, it’s a GREAT thing as one of the functions of testosterone is to rapidly increase protein synthesis in cells, leading to bigger and stronger muscles.

    Balunas MJ, Su B, Riswan S, Fong HH, Brueggemeier RW, Pezzuto JM, Kinghorn AD. Isolation and Characterization of Aromatase Inhibitors from Brassaiopsis glomerulata (Araliaceae). Phytochem Lett. 2009 Feb 19;2(1):29-33.
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    Quote Originally Posted by Sldge View Post
    Triazole™ introduces a BRAND NEW compound to the industry that we call pZole™. pZole™ is a NATURAL aromatase inhibitor (AI) found in the shrub Brassaiopsis glomerulata. This shrug is native to South Asia where it is used to treat rheumatism and back pain. Brassaiopsis glomerulata has been shown to contain several natural AI, of which, pZole™ has been shown to be the strongest. In fact, during a comparison study with the prescription drug Letrozole (a potent AI) there was no statistical difference between it and pZole™ with regards to aromatase inhibition!

    Aromatase is the enzyme that converts androgens like testosterone into estrogens and is the main way by which males generate estrogen. When aromatase is inhibited, your brain will detect lower levels of estrogen and will in turn respond by increasing testosterone levels significantly. In case you didn’t know, this is a good thing. Actually, it’s a GREAT thing as one of the functions of testosterone is to rapidly increase protein synthesis in cells, leading to bigger and stronger muscles.

    Balunas MJ, Su B, Riswan S, Fong HH, Brueggemeier RW, Pezzuto JM, Kinghorn AD. Isolation and Characterization of Aromatase Inhibitors from Brassaiopsis glomerulata (Araliaceae). Phytochem Lett. 2009 Feb 19;2(1):29-33.

    So Triazole is Herbal?
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    Just an FYI for your write up, but there's what seems to be a Freudian slip:

    ...This SHRUG is native to South...
    It says SHRUG instead of SHRUB
    RcB Since 09-06-2011 20:55 EST, Post 49
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    I must say I am interested.
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    Quote Originally Posted by MAxximal View Post
    So Triazole is Herbal?
    The ATDs and 6-bromos are not long for this world. FDA crackdown. This may be herbal, but the results are equivalent!
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    Quote Originally Posted by stxnas View Post
    Just an FYI for your write up, but there's what seems to be a Freudian slip:



    It says SHRUG instead of SHRUB
    Ha, typo!
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    Quote Originally Posted by Robboe View Post
    The ATDs and 6-bromos are not long for this world. FDA crackdown. This may be herbal, but the results are equivalent!
    Sweet!
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    Quote Originally Posted by stxnas View Post
    Just an FYI for your write up, but there's what seems to be a Freudian slip:



    It says SHRUG instead of SHRUB
    I have fixed this 3 times. On my screen i see shrub. Is it fixed?

    Quote Originally Posted by Robboe View Post
    Ha, typo!
    Very weird.
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    Quote Originally Posted by Sldge View Post
    pZole™ is a NATURAL aromatase inhibitor (AI) found in the shrub Brassaiopsis glomerulata. This shrug is native to South Asia where it is used to treat rheumatism and back pain.
    First one fixed, second one is still there
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    Lets try it again.
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    Classic love it!
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    Quote Originally Posted by Sldge View Post
    I have fixed this 3 times. On my screen i see shrub. Is it fixed?

    Very weird.
    Quote Originally Posted by Sldge View Post
    Lets try it again.
    You got it

    I wasn't trying to be negative. I just know how much it irritates me when that happens to us and then I see it copy and pasted everywhere, lol.
    RcB Since 09-06-2011 20:55 EST, Post 49
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    Another little tidbit for you fellas:

    One of our alpha testers of pZole reported a decrease in estrogen of 41%, and his free testosterone went from a level of 64.3 to193.4 -- that is a 300% INCREASE!
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    Hmm, interesting...
    RcB Since 09-06-2011 20:55 EST, Post 49
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    Quote Originally Posted by Robboe View Post
    Another little tidbit for you fellas:

    One of our alpha testers of pZole reported a decrease in estrogen of 41%, and his free testosterone went from a level of 64.3 to193.4 -- that is a 300% INCREASE!
    Attachment 34410
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    Quote Originally Posted by AZMIDLYF View Post
    lol.
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    when is this comming after pct i will through this in.

    i always run 2 pcts after inj cycles.
    1st being clomid nolva for 4 weeks then i do a OTC pct rightb after which will be this product with some natty test booster. and powerfull ( prolactin i used tren)
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    How does triazole and activate extreme compare to the original NHA stack using the rebound reloaded with 6 bromo? What can one expect?
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    Quote Originally Posted by biopole View Post
    How does triazole and activate extreme compare to the original NHA stack using the rebound reloaded with 6 bromo? What can one expect?
    in for answer
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    Quote Originally Posted by biopole View Post
    How does triazole and activate extreme compare to the original NHA stack using the rebound reloaded with 6 bromo? What can one expect?
    Based on the user bloodwork, this should be as good in terms of testosterone boosting, but EVEN BETTER when you consider that there will be no negative side effect on your sex drive.
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    It seems through the old logs that 6-bromo had a great effect on recomposition, users reported gaining on the average 3-4 lbs., while having a smaller waste. will triazole have this same effect?

    Also, off subject. Is the new glucophase still in development or has that project been eliminated?
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    Quote Originally Posted by biopole View Post
    It seems through the old logs that 6-bromo had a great effect on recomposition, users reported gaining on the average 3-4 lbs., while having a smaller waste. will triazole have this same effect?
    We certainly hope. You can follow along with a guy running a log on bodyspace here: http://blog.bodybuilding.com/bigTtK

    He is running quite a low calorie diet during, so the scale will likely only be going down, but he showed us some progress pics after just two weeks:



    His strength is still climbing for the most part.

    Also, off subject. Is the new glucophase still in development or has that project been eliminated?
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    Another morsel for you guys:

    Prunella Vulgaris is a highly esteemed traditional medicinal herb that is affectionately known as “heal-all”. It gets this name thanks to the diversity of ailments it has been purported to fix. These include anti-inflammatory and anti-bacterial effects, its ability to reduce fevers, stomach problems and even lower blood pressure. More recently, new research into its effects on cancer and diabetes have come to light. Prunella Vulgaris has been demonstrated to have anti-estrogenic properties through its effect in activating the Aryl hydrocarbon receptor (AHR) which can interfere with estrogen. Further proof of this effect is displayed in its effect on inhibiting the estrogen-induced enzyme, CYR61, which has recently been suggested as a biomarker for prostate cancer.


    Collins NH, Lessey EC, DuSell CD, McDonnell DP, Fowler L, Palomino WA, Illera MJ, Yu X, Mo B, Houwing AM, Lessey BA. Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models. Biol Reprod. 2009 Feb;80(2):375-83.
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    Some more studies on Prunella for those interested.

    Immune modulatory effects of Prunella vulgaris L.
    Int J Mol Med. 2005 Mar;15(3):491-6.
    Prunella vulgaris has a wide array of biological effects exhibiting numerous therapeutic potentials. Its anti-microbial effects including anti-viral and anti-bacterial effects are, presently, receiving increasing attention. While its anti-viral effects are attributed mainly to the inhibition of virus replication, the biological mechanisms of its anti-bacterial effects or actions remain unknown. In view of the fact that polysaccharides isolated from medicinal herbs often function as biological response modifier of body immunity, we hypothesized that the anti-microbial effect of polysaccharides isolated from Prunella vulgaris is probably also mediated via immune modulation. We have isolated four polysaccharides containing fractions from Prunella vulgaris, one of the fractions, PV2, could markedly stimulate the production of superoxide and nitrite representing nitric oxide from murine macro****e RAW264.7 and brain macro****e BV2 cells. The amount of nitrite and superoxide produced after PV2 stimulation was as high as that seen in stimulation using bacterial endotoxin lipopolysaccharide (LPS), and this stimulatory response is dose-dependent. In addition to monocyte/macro****e, PV2 also stimulated the proliferation of splenocytes. In this study, we have shown that the polysaccharides isolated from Prunella vulgaris have marked immune stimulatory effects, which may bring about the anti-microbial effects of Prunella vulgaris.

    A polysaccharide fraction from medicinal herb Prunella vulgaris downregulates the expression of herpes simplex virus antigen in Vero cells.
    J Ethnopharmacol. 2004 Jul;93(1):63-8.
    Herpes simplex viruses are pathogenic. With the emergence of drug-resistant strains of Herpes simplex virus, new antiviral agents, especially those with different modes of action, are urgently needed. Prunella vulgaris L. (Labiatae), a perennial plant commonly found in China and Europe, has long been used as a folk medicine to cure ailments. In this study, a polysaccharide fraction was prepared from Prunella vulgaris, and its effects on the expressions of Herpes simplex virus-1 and Herpes simplex virus-2 antigens in their host Vero cells were investigated with flow cytometry. The Herpes simplex virus antigen increased time-dependently in the infected cells, and Prunella vulgaris reduced its expression. The effective concentrations of Prunella vulgaris with 50% reductions of the Herpes simplex virus-1 and Herpes simplex virus-2 antigens were 20.6 and 20.1 microg/ml, respectively. The novelty of Prunella vulgaris is that it also reduces the antigen expression of acyclovir-resistant strain of Herpes simplex virus-1. After incubations with 25-100 microg/ml of Prunella vulgaris the Herpes simplex virus antigen-positive cells were reduced by 24.8-92.6%, respectively, showing that this polysaccharide fraction has a different mode of anti-Herpes simplex virus action from acyclovir. Results from this study show that Prunella vulgaris is effective against both the Herpes simplex virus-1 and Herpes simplex virus-2 infections, and flow cytometry offers a quantitative and highly reproducible anti-Herpes simplex virus drug-susceptibility assay.

    Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats.
    Pharmacol Res. 2004 Aug;50(2):123-30.
    The study tested the effects of phenolics-rich extracts from the plants Silybum marianum (silymarin) and Prunella vulgaris on blood and liver antioxidant status and lipoprotein metabolism. These results indicate that silymarin and Prunella vulgaris improve antioxidant status in blood and liver and positively affect plasma lipoprotein profile in an experimental model of dietary induced hypertriglyceridemia.

    Biological activities of Prunella vulgaris extract.
    Phytother Res. 2003 Nov;17(9):1082-7.
    The organic fraction (OF; 25.7% w/w of rosmarinic acid) of Prunella vulgaris (total extract) was found to exhibit the following: scavenging activity on diphenylpicrylhydrazyl radical (DPPH), inhibition of in vitro human LDL Cu(II)-mediated oxidation, protection of rat mitochondria and rat hepatocytes exposed to either tert-butyl hydroperoxide, or to Cu(II) and Fe(III) ions. OF also showed a potential to inhibit rat erythrocyte haemolysis and it reduced the production of LTB(4) in bovine PMNL generated by the 5-lipoxygenase pathway. Other observations included antiproliferative effects against HaCaT cells and mouse epidermal fibroblasts and a moderate OF antimicrobial activity on gram-positive bacteria. Rosmarinic, caffeic and 3-(3,4-dihydroxyphenyl)lactic acids exhibited less potent activity than the plant extract in all bioassays. The antioxidative, antimicrobial, together with antiviral effects offer good prospects for the medicinal applications of Prunella vulgaris.

    Identification of inhibitors of the HIV-1 gp41 six-helix bundle formation from extracts of Chinese medicinal herbs Prunella vulgaris and Rhizoma cibotte.
    Life Sci. 2002 Aug 30;71(15):1779-91.
    An increasing portion of patients with HIV infection and/or AIDS cannot use currently FDA-approved anti-HIV drugs, including the reverse transcriptase and protease inhibitors, due to the adverse effects and the emergence of drug resistance. Thus, it is essential to develop new anti-HIV agents with a target different from the HIV reverse transcriptase and protease. Using a conformation-specific monoclonal antibody NC-1, we previously established a high throughput screening assay for identification of small molecular organic compounds that disrupt the HIV-1 gp41 six-helix bundle formation, a critical step of membrane fusion between the HIV and the target cell. In the present study, we used this assay to screen for inhibitors of the gp41 six-helix bundle formation from aqueous extracts of nine Chinese medicinal herbs with antiviral activity. We found that the extracts of two herbs, Prunella vulgaris and Rhizoma cibotte, showed potent inhibitory activity. The inhibitory activity of these two herb extracts significantly decreased after they were passed through polyamide resin mini-columns, which are able to bind polyphenols including tannin, an HIV-1 inhibitor with multiple mechanisms of action. The bound polyphenols were eluted from the polyamide columns and also showed potent inhibitory activity on the gp41 six-helix bundle formation. Tannin purchased from different commercial sources inhibited the gp41 six-helix bundle formation in a manner similar to the polyphenols isolated from the herb extracts. These results suggest that tannin may be one of major inhibitors of the HIV-1 gp41 six-helix bundle formation in the herb extracts and that tannin may inhibit HIV-1 entry by disrupting the gp41 six-helix bundle formation.

    Inhibition of immediate-type allergic reactions by Prunella vulgaris in a murine model.
    Immunopharmacol Immunotoxicol. 2001 Aug;23(3):423-35.
    We studied the effect of aqueous extract of Prunella vulgaris (Labiatae) on immediate-type allergic reactions. Prunella vulgaris (0.005 to 1 g/kg) dose-dependently inhibited systemic anaphylactic shock induced by compound 48/ 80 in rats. When Prunella vulgaris was given as pretreatment, at concentrations ranging from 0.005 to 1 g/kg, the serum histamine levels induced by compound 48/ 80 were reduced in a dose-dependent manner. Prunella vulgaris (0.001 to 1 g/kg) inhibited the passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody dose dependently. Prunella vulgaris also inhibited the histamine release induced by compound 48/80 or anti-DNP IgE from the rat peritoneal mast cells (RPMC). The level of cyclic AMP in RPMC, when Prunella vulgaris was added, significantly increased, compared with that of normal control. Moreover, Prunella vulgaris (0.01 and 0.1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-mediated tumor necrosis factor-alpha production from RPMC. These results indicate that Prunella vulgaris inhibits immediate-type allergic reactions in rats.

    Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris.
    Planta Med. 2000 May;66(4):358-60.
    The activity-guided fractionation of the extract of the herb of Prunella vulgaris (Labiatae) led to the isolation of four triterpenes, i.e., betulinic acid, ursolic acid, 2 alpha,3 alpha-dihydroxyurs-12-en-28-oic acid, and 2 alpha-hydroxyursolic acid. One of these compounds, 2 alpha,3 alpha-dihydroxyursolic acid, demonstrated significant inhibition on the release of beta-hexosaminidase from the cultured RBL-2H3 cells in a dose-dependent manner; the IC50 value was calculated to be 57 microM. When the isolated compounds were tested for their effects on the production of nitric oxide from cultured murine macro****es, RAW 264.7 cells, ursolic acid and 2 alpha-hydroxyursolic acid exhibited strong inhibitory activities (IC50 values, 17 and 27 microM, respectively).
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    Quote Originally Posted by Robboe View Post
    Another little tidbit for you fellas:

    One of our alpha testers of pZole reported a decrease in estrogen of 41%, and his free testosterone went from a level of 64.3 to193.4 -- that is a 300% INCREASE!
    Here is a scan of the bloodwork in question.




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    Wow.
    Just inject.
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    Test subject 04 pre-set blood work series (5/13/2010):


    Test subject 04 post-set of blood work series (6/15/2010):


    Thats an increase in total testosterone of roughly 90%, an increase in free testosterone of roughly 100% while keeping estrogen levels below the testing thresh hold.
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    Quote Originally Posted by Sldge View Post
    Thats an increase in total testosterone of roughly 90%, an increase in free testosterone of roughly 100% while keeping estrogen levels below the testing thresh hold.
    BOOM.

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