IBE Reverse: What do you think?
- 07-24-2008, 10:32 AM
- 07-24-2008, 10:50 AM
07-24-2008, 11:48 AM
07-24-2008, 11:00 PM
Does anybody know what it takes to get Resveratrol to mimic calorie restriction/longevity?
Sinclair's 2006 study showed no matter what the diet resveratrol when taken later in life (i.e quivalent to 35 human years) made the life of the mice healthier (thicker bones, no cataracts, stronger heart, less mitochondria damage)...which is great but did not extend the life span.
I haven't spent much time on this but would appreciate it if someone could point to newer source material and/or give me their thoughts on what is needed.
For instance do we need to have resveratrol active constantly in blood plasma (i.e. time released)?
Is their a sweet spot...such that too much & too little don't adequately activate the SIRT1 enzyme?
Has anyone ever contemplated an injectable?
Has anyone thoughts on the difference between resveratrol bringing on a healthier life vs resveratrol bringing on both a healthier & life-span extended life?
What limitations to oral dosing of plain resveratrol will Lake's acetylation REALLY overcome. Is it just more bioavailability at once....more time released element to it... and is this experimental formulation a potential way to get resveratrol to act "more intently" on activating sirtuins?
I'm not asking anybody to do my leg work for me ...just a thought here or there would be great. Thanks guys.
07-25-2008, 11:24 PM
next would be to find out if an injectable form of it would be better since we are skipping the first pass through the liver.
07-26-2008, 10:48 AM
This is another reason that we made Reverse. As the article states the bioavailability is low despite the dosage and the rate of absorption is very slow.
Pharm Res. 2008 Jul 16. [Epub ahead of print]
The Impact of Aqueous Solubility and Dose on the Pharmacokinetic Profiles of Resveratrol.
Das S, Lin HS, Ho PC, Ng KY.
Department of Pharmacy, Faculty of Science, National University of Singapore, Building S4, Rm 05-02, 18 Science Drive 4, Singapore, 117543, Singapore.
PURPOSE: This study aimed at the investigation of the impact of aqueous solubility and dose manipulation on the pharmacokinetics of resveratrol. METHODS: Water soluble intravenous and oral formulations of resveratrol were prepared with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and randomly methylated-beta-cyclodextrin (RM-beta-CD), respectively. Sodium salt and suspension of resveratrol in carboxymethyl cellulose (CMC) were used as the reference intravenous and oral formulations, respectively. The pharmacokinetics of resveratrol was assessed in Sprague-Dawley rats. Plasma resveratrol concentrations were measured by high performance liquid chromatography (HPLC). RESULTS: Both HP-beta-CD and RM-beta-CD enhanced the aqueous solubility of resveratrol. After intravenous administration, rapid elimination of resveratrol was observed at all tested doses (5, 10, and 25 mg kg(-1)) regardless of formulation types; with non-linear elimination occurring at the dose of 25 mg kg(-1). RM-beta-CD significantly increased the maximal plasma concentration of orally administered resveratrol, but, it did not increase the oral bioavailability in comparison with the CMC suspension. Furthermore, the oral bioavailability remained unchanged among all tested doses (15, 25, and 50 mg kg(-1)). CONCLUSIONS: Aqueous solubility barrier might affect the speed but not the extent of resveratrol absorption. Further, dose manipulation (up to 50 mg kg(-1)) did not have a significant impact on the oral bioavailability of resveratrol.
07-26-2008, 12:20 PM
Lake you could be a lawyer. You shepardize really well. (i.e. cite the latest most up to date legal precedent).
I have access to the full Pharmacological Research journal but the abstract you dug up is ahead of publication.
I appreciate you giving me the easy answer on this one. Wow that is pretty definitive. Actually IF we can extrapolate from the study there was no increase in bioavailability up to the equivalent of 4 grams dosing for an 80 kilo man.
This may explain why the 2006 study showed health benefits in aged mice but no extended life span (they couldn't get resveratrol levels high enough).
Now I see why you are so excited about your "baby". Your potential market is huge...way beyond the bodybuilding community.
Make sure you file a patent application that also includes you not just IBE.
Thanks again bro... you saved me a bunch of time.
07-26-2008, 01:37 PM
Reverse seems to be one of the most promising product to be released. I have used plain resveratrol for may years now and just can't wait to try this. How much longer do we have to wait? Would this be a "feel" kinda product --i.e. you can actually tell that some positive changes are taking place in your body after using it for some time? Has this undergone any beta-testing yet?
07-26-2008, 01:43 PM
I know the Shilijit is able to be "felt" by some. As for the new resv. I will let lake answer that one for you. If you have any type of B12 def. then you will definitely feel it.
The Historic PES Legend
07-26-2008, 05:16 PM
07-28-2008, 04:29 AM
I could not agree more, DB. I saw the following in the Life Extension Magazine. You probably have seen it, too:
GlaxoSmithKline Invests in Resveratrol Research
For years Life Extension magazine has been reporting on the multiple health benefits of resveratrol. We have urged members to incorporate this vital nutrient into their personal life-extension program. Now, pharmaceutical companies see the financial potential of creating a prescription drug from resveratrol compounds in order to treat age-related disease. Recently, pharmaceutical giant GlaxoSmithKline announced that it would acquire all outstanding shares of Sirtris Pharmaceuticals for $720 million in order to cash in on the life-extending promise of resveratrol-based compounds.1
Found in red grapes and wine, resveratrol has been credited with extending life span in a variety of organisms.2,3 Resveratrol mimics the life-extending properties of caloric restriction by activating enzymes called sirtuins, which influence a variety of aging-related metabolic functions.
Sirtris was founded in 2004 after Dr. David Sinclair of Harvard Medical School began publishing findings regarding resveratrolís remarkable potential benefits.2 Sirtrisí stated goal is to discover and develop small molecules with anti-aging potential, and its research efforts have largely focused on enhancing the potency of resveratrol-based compounds.
GlaxoSmithKline evidently hopes to modify the resveratrol molecule to further bolster its bioavailability and effects. Such a modification would also allow the drug company to patent the new molecule and market it exclusively.
1. Available at: http://www.gsk.com/media/pressreleas...ease_10038.htm. Accessed April 30, 2008.
2. Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003 Sep 11;425(6954):191-6.
3. Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16;444(7117):337-42.
07-28-2008, 11:25 AM
07-28-2008, 11:39 AM
07-28-2008, 11:53 AM
07-28-2008, 12:28 PM
07-28-2008, 01:14 PM
07-30-2008, 12:37 AM
07-31-2008, 06:43 PM
08-01-2008, 12:16 AM
08-05-2008, 06:26 AM
08-05-2008, 10:53 AM
As always we are just waiting on one last company to finish up what they are doing so we can move forward. We already have the ingredients so there is no problem there. I will get some testers this week .
08-05-2008, 10:59 AM
08-05-2008, 11:09 AM
08-05-2008, 11:33 PM
08-17-2008, 10:39 AM
08-17-2008, 11:16 AM
08-17-2008, 11:31 AM
08-17-2008, 03:23 PM
Just a few questions: 1) How many capsules per bottle? 2) What quantity of Triacetylated Resveratrol per capsule? and 3) Can I expect to receive this within a week's time as I leave for vacation in just over a week?
08-17-2008, 04:43 PM
Pardon the ignorance but isnt this similar to how CLA works?
(via PPAR-deta expression)
""Dr. Evans and his team found that the PPAR-delta protein remodeled the muscle, producing more of the high-endurance Type 1 fiber. They genetically engineered a strain of mice whose muscles produced extra amounts of PPAR-delta. These mice grew more Type 1 fibers and could run twice as far as on a treadmill as ordinary mice before collapsing.
Given that people cannot be engineered in this way, Dr. Evans wondered whether levels of the PPAR-delta protein could be raised by drugs. Pharmaceutical companies have long tried to manipulate PPAR-delta because of its role in fat metabolism, and Dr. Evans found several drugs were available, although they had been tested for different purposes.
08-23-2008, 12:02 PM
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