Needed: A few good soldiers to test our new PX BLACK

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  1. thebigt - representing the Navy, hoo yah!!!!
    After a year off, I'm back


  2. Quote Originally Posted by snagencyV2.0 View Post
    we have a patent-pending ingredient in IrisinXD, and i wasn't sure about early disclosure of this compound, hence the suspense.
    i am excited for this one!
    "Irisin is a hormone being researched by scientists at the Harvard Medical School that can replicate some of the positive effects of exercise"

    Like the sound of that...
    Unremarkable is no way to go through life... Doug
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  3. Quote Originally Posted by DreamWeaver View Post
    "Irisin is a hormone being researched by scientists at the Harvard Medical School that can replicate some of the positive effects of exercise"

    Like the sound of that...
    So it consumes calories upon dosage?
    >SNS-Glycophase<
    Serious Nutrition Solutions Rep

  4. Quote Originally Posted by Celorza View Post
    So it consumes calories upon dosage?
    Mechanism Exercise causes increased expression of PGC-1alpha in muscle, involved in muscle adaptation to exercise. This increase causes production of the protein Fndc5 in mice, then Fndc5 is cleaved to give a new product, which the researchers named Irisin, after the Greek goddess Iris.[3][4]
    Effects

    Fat

    The scientists have reported that the hormone helps convert "white fat" to "brown fat" . Brown fat has typically been found only in small amounts in adults, but is common in babies and children. Brown fat burns calories into heat, a process known as thermogenesis. [5][6]
    Diabetes

    Dr. Spiegelman's staff injected irisin into obese, pre-diabetic laboratory mice and the animals displayed improved glucose tolerance when fed a high-fat diet.
    Weight loss

    After 10 days of treatment with the irisin injections, the mice lost a small amount of weight.
    Unremarkable is no way to go through life... Doug

  5. Quote Originally Posted by DreamWeaver View Post
    Mechanism Exercise causes increased expression of PGC-1alpha in muscle, involved in muscle adaptation to exercise. This increase causes production of the protein Fndc5 in mice, then Fndc5 is cleaved to give a new product, which the researchers named Irisin, after the Greek goddess Iris.[3][4]
    Effects

    Fat

    The scientists have reported that the hormone helps convert "white fat" to "brown fat" . Brown fat has typically been found only in small amounts in adults, but is common in babies and children. Brown fat burns calories into heat, a process known as thermogenesis. [5][6]
    Diabetes

    Dr. Spiegelman's staff injected irisin into obese, pre-diabetic laboratory mice and the animals displayed improved glucose tolerance when fed a high-fat diet.
    Weight loss

    After 10 days of treatment with the irisin injections, the mice lost a small amount of weight.
    So it will help with thermogenesis (thus enhancing the caloric burn by TEF or exercise) and help with Insulin Sensitivity...Now the thing is, how long does it take to have it's effect on white fat/brown fat and, is this a study as per human data, or did the dosage of Irisin went through a human equivalent dosage? Or has it been tested on humans to show the same effect as mice?
    >SNS-Glycophase<
    Serious Nutrition Solutions Rep
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  6. Quote Originally Posted by Celorza View Post
    So it consumes calories upon dosage?
    I am giving you the research as I find it, it's new to me also...there has been artticles aobut it...
    Unremarkable is no way to go through life... Doug

  7. From and article is science daily more neat stuff about it...

    Irisin is a recently identified hormone secreted from muscle cells that has been found to serve as a chemical messenger providing key exercise-induced health benefits in mice. In these earlier studies, irisin showed direct effects on 'browning' of white fat which would lead to burning of excess calories. Discovery of irisin therefore raised expectations of potential for developing new therapies for metabolic diseases.
    In their study, Dr. Mantzoros and his team of researchers went one step further by uncovering the role of irisin in humans. They reported that whereas the cleaved soluble part of the FNDC5 molecule (irisin) is readily detectable in human plasma, the uncleaved and unprocessed molecule FNDC5 is only rarely detectable.
    They studied possible predictors of circulating irisin concentrations by performing cross-sectional and interventional studies in humans. They found that irisin levels reflect muscle mass primarily and are higher in younger male athletes than in older women. Also, muscle mRNA expression of FNDC5 was strongly and positively correlated with PGC1-α mRNA levels which confirms irisin as a myokine, a hormone secreted by muscle.
    The Mantzoros group addressed the controversy of whether irisin levels change in humans during exercise by comparing levels in young healthy males who performed acute sprint runs and chronic sprint training for eight weeks. The results showed that irisin levels increase in response to acute exercise and irisin levels are closely and negatively associated with muscle ATP levels, pointing to a need for a prompt secretion of irisin after acute exercise to meet the needs for ATP and metabolite synthesis in muscle. Also reported were associations of irisin with growth factors, which increase muscle mass and metabolic outcomes in normal humans; a finding which will require confirmation by future studies.
    Although this clinical study has revealed a significant amount of novel information regarding the physiological role of irisin in humans, much remains unknown regarding its function as a hormone and the regulation of FNDC5 synthesis and irisin secretion.
    Unremarkable is no way to go through life... Doug

  8. I will throw my hat in for this one. Been off supps for a while. Time to rededicate and take charge.

  9. Quote Originally Posted by DreamWeaver View Post
    I am giving you the research as I find it, it's new to me also...there has been artticles aobut it...
    Was on my phone sorry haha, hence I asked. I'll look for stuff on it too thanks Doug!
    >SNS-Glycophase<
    Serious Nutrition Solutions Rep

  10. That Irisin is interesting stuff. I can tolerate very low amounts of yohimbine. Too much though and I am laying in bed shivering in a cold sweat with a mega boner that I can't do anything with.

  11. Quote Originally Posted by Celorza View Post
    Was on my phone sorry haha, hence I asked. I'll look for stuff on it too thanks Doug!
    NP, lol yah it's pretty exciting stuff the articles seem to be mostly touting the Harvard study...

    Quote Originally Posted by mattikus View Post
    That Irisin is interesting stuff. I can tolerate very low amounts of yohimbine. Too much though and I am laying in bed shivering in a cold sweat with a mega boner that I can't do anything with.
    ouch ...
    Unremarkable is no way to go through life... Doug

  12. I am a soldier, been one for years (ref username). I have some unwanted body fat that I'd like to shed. This can be considered an app.

  13. Quote Originally Posted by snagencyV2.0 View Post
    guys - PM me your info, you're in.
    hot damn...i have to say i am impressed.....profile looks amazing!!!


    with the pea's/caffeine and yohimbe plus sulbutamine i am hopeful this formula will get me cranked up....plus the 3,5 and advantra!!!


    i am pumped to give this a shot-hell yeah...lets get ready to rumble!!!!
    GOD, FAMILY, COUNTRY!!!

  14. Yeah the profile is very comprehensive and novel as well. I love the inclusion of 3-5 and very curious about what kind of impact the IRISIN is going to have.
    Live Hard, Laugh Hard, Love Hard and Heal Fast! - KLEEN
    Current Training Log -
    http://anabolicminds.com/forum/workout-logs/276206-kleen-strong-body.html

  15. Quote Originally Posted by Cary K View Post
    thebigt - representing the Navy, hoo yah!!!!
    the jolly roger skull and crossbones is at full mast....avast me mateys-


    shiver me timbers!!!!

    no polliwogs allowed....shellbacks be representin!!!
    GOD, FAMILY, COUNTRY!!!

  16. Quote Originally Posted by MrKleen73 View Post
    Yeah the profile is very comprehensive and novel as well. I love the inclusion of 3-5 and very curious about what kind of impact the IRISIN is going to have.
    well....we are gonna find out!!!!

    i'm your huckleberry!!!!
    GOD, FAMILY, COUNTRY!!!

  17. Quote Originally Posted by thebigt View Post
    well....we are gonna find out!!!!

    i'm your huckleberry!!!!
    Did you know that is the most misquoted line from a movie ever? I didn't until i read it and the had to go look it up.

    He actually says "I'm your Huckle Bearer."

    Apparently the pine box coffins back then were called a Huckle, the people we call Pal Bearers now the ones who care the caskets were Huckle Bearers. So he was basically telling the guy I will put you in your coffin / carry you to deaths door...
    Live Hard, Laugh Hard, Love Hard and Heal Fast! - KLEEN
    Current Training Log -
    http://anabolicminds.com/forum/workout-logs/276206-kleen-strong-body.html

  18. Quote Originally Posted by Onlychevy6 View Post
    I will throw my hat in for this one. Been off supps for a while. Time to rededicate and take charge.
    addy, please


    Quote Originally Posted by iparatroop View Post
    I am a soldier, been one for years (ref username). I have some unwanted body fat that I'd like to shed. This can be considered an app.
    we love our troops, send me your info!

    Quote Originally Posted by mattikus View Post
    That Irisin is interesting stuff. I can tolerate very low amounts of yohimbine. Too much though and I am laying in bed shivering in a cold sweat with a mega boner that I can't do anything with.
    so matt
    are you in
    or are you out?

  19. Quote Originally Posted by MrKleen73 View Post
    Did you know that is the most misquoted line from a movie ever? I didn't until i read it and the had to go look it up.

    He actually says "I'm your Huckle Bearer."

    Apparently the pine box coffins back then were called a Huckle, the people we call Pal Bearers now the ones who care the caskets were Huckle Bearers. So he was basically telling the guy I will put you in your coffin / carry you to deaths door...
    son of a gun...didn't know that. it actually makes more sense, lol.


    i am gonna use that next time someone pisses me off, lol...thanks, chris!!!!
    GOD, FAMILY, COUNTRY!!!

  20. Count me in. I will do it for all those sensitive to yohimbine.
  21. 3 MORE! GOING QUICK!


    all right, 7 down. looks like a mean (and soon to be lean) LOGGING crew for sure!

    don't miss out on this opportunity people, 3 more to go!

    get dem apps in heah!

  22. Quote Originally Posted by MrKleen73 View Post
    Did you know that is the most misquoted line from a movie ever? I didn't until i read it and the had to go look it up.

    He actually says "I'm your Huckle Bearer."

    Apparently the pine box coffins back then were called a Huckle, the people we call Pal Bearers now the ones who care the caskets were Huckle Bearers. So he was basically telling the guy I will put you in your coffin / carry you to deaths door...
    You learn something new everyday. Thanks for that tid-bit of movie trivia
    After a year off, I'm back

  23. Pm sent and thank you again...
    Chaos and Pain -Rep

    Use Discount code: onlychevy620 for your 20% off

  24. Must say I'm a little surprised that the formula is a complete reboot. I thought the old way great but one thing I've learned is to trust these guys haven't been disappoint yet.

  25. Yeah I am extremely impressed with the revamp. It should be ridiculous I will be logging it soon as I get some.
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